DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and CLCNKA

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_004061.3	Gene:	CLCNKA / 1187	HGNCID:	2026	Length:	687	Species:	Homo sapiens

Alignment Length:	756	Identity:	211/756 - (27%)
Similarity:	330/756 - (43%)	Gaps:	161/756 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 LVGIAAGCVAGMVDIGASWMSDLKHGICP--------PAFWFNREQCCYPAKQSVFEEGNCSTW- 268
            |||:..|.....|.:...|      |.||        ...|.         ||.||..|  ..|
Human     4 LVGLREGFSGDPVTLQELW------GPCPHIRRAIQGGLEWL---------KQKVFRLG--EDWY 51

  Fly   269 --------------------------KTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLV 307
                                      ..|     |.|.....:::.|:.:.::.:...|.|:...
Human    52 FLMTLGVLMALVSYAMNFAIGCVVRAHQW-----LYREIGDSHLLRYLSWTVYPVALVSFSSGFS 111

  Fly   308 RMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLT--LGKEGPMVH----I 366
            :...|.:.||||||:||:|:|.|:..||.......|.|||..:::.|.|  |||.||.||    |
Human   112 QSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMI 176

  Fly   367 ASCIGNIFSHVFPKYGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSF 431
            |:.:|.:.:....: ..|::|:.|:|.||||.||:..|.||..|||||:|.:|.:|.::..||.|
Human   177 AAYLGRVRTTTIGE-PENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGF 240

  Fly   432 FCALIAAFVLRSLTPFGNEHSVL-------FFVE--YNKPWIFFELIPFVFLGIMGGVIG----- 482
            |.|...||:.|.|..|.:|...:       |.|:  ::.|.|||    ||.||.:.||:.
Human   241 FAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFF----FVALGGICGVLSCAYLF 301

  Fly   483 ---TF--FIKANLWWCRYRKFSKLGQYPVMEVLFVTLVTAIICYPNPFTRMNMNELIFLLVSKCS 542
               ||  |||.|.:..:....||    ||...| .||:.|.|.||.....        .|.|:.|
Human   302 CQRTFLSFIKTNRYSSKLLATSK----PVYSAL-ATLLLASITYPPGVGH--------FLASRLS 353

  Fly   543 PGDVTNPLCDYKRMNITSGNS-------------FIEVTEPGPGVYSSI--WLLMLTFILKLALT 592
            .....:.|.|.....:.:.||             :.|...|...::.::  :|:|..::|.||.|
Human   354 MKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATT 418

  Fly   593 IFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGAA 657
            |     .:|||.|:|..:|||.:||::|   |..|.::|. ...||  ..:|.|.||.||:.|||
Human   419 I-----PMPAGYFMPIFILGAAIGRLLG---EALAVAFPE-GIVTG--GVTNPIMPGGYALAGAA 472

  Fly   658 AVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLD-- 720
            |..|.||. |:|..::.|||||.:.:.:|::.|.:|:..:..:. :...||..|.:...|:|.
Human   473 AFSGAVTH-TISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRI 535

  Fly   721 -SKEEFAHTTLAADVMQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVL 784
             .:...:|.......|    |.::..:.:|: .:::|..::..|:...||:|.|.|:|.|||.|.
Human   536 LGRNIGSHHVRVEHFM----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQILVGIVQ 595

  Fly   785 RRDLNLAIGNAKRLIEGISSSSIVLFTSSQPIQNLGPQPLKLKKIL----DMAPITVT--DQTPM 843
            |..|..|:                  .:..|.:..|.|.. |:.||    ...|:|:|  .:|.:
Human   596 RAQLVQAL------------------QAEPPSRAPGHQQC-LQDILARGCPTEPVTLTLFSETTL 641

  Fly   844 ETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQMDN 884
            ....::|:.|.|:...||..||.:|.::..::.:.:..:.|
Human   642 HQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	170/578 (29%)
		Voltage_CLC	298..699	CDD:279048	148/440 (34%)
		CBS	738..876	CDD:223591	35/143 (24%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	34/142 (24%)
CLCNKA	NP_004061.3	ClC_1_like	49..534	CDD:239655	158/520 (30%)
		Voltage_CLC	106..513	CDD:279048	147/436 (34%)
		CBS_pair_EriC_assoc_euk_bac	555..676	CDD:239964	34/140 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154999
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55339
OrthoDB	1	1.010	-	-		D271925at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.760