DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and CLCN7

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_001278.1	Gene:	CLCN7 / 1186	HGNCID:	2025	Length:	805	Species:	Homo sapiens

Alignment Length:	749	Identity:	233/749 - (31%)
Similarity:	348/749 - (46%)	Gaps:	163/749 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 WLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSV---FEEGNCSTWK 269
            |:...|:||..|.||..:||....::.||:.:               .|.::   .|:|..|
Human   127 WVICALIGILTGLVACFIDIVVENLAGLKYRV---------------IKGNIDKFTEKGGLS--- 173

  Fly   270 TWPEIFGLDRNGTGPYIVAYIWYVLWALL---FASLSASLVRMFAPYACGSGIPEIKTILSGFII 331
                 |.|               :|||.|   |..:.:.:|....|.|.|||||:||..|:|..|
Human   174 -----FSL---------------LLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKI 218

  Fly   332 RGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSH-----------VFPKYGRNE 385
            ...:...||:||..|::|||..||.:||||||:|..|.|....|.           :| :|.|.:
Human   219 PHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIF-EYFRRD 282

  Fly   386 AKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLR-------- 442
            .:||:.:||.||||||.|||||:|||||||||.:.::.....||.||.::|:.|.|.
Human   283 TEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHG 347

  Fly   443 --------SLTPFGNEHSVLFFVEYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYR-KF 498
                    .|..||.      |......:...|:..|:.:|::|||:|..|...|.|...:| ::
Human   348 NMWDLSSPGLINFGR------FDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRY 406

  Fly   499 SKLGQYPVMEVLFVTLVTAIICYPNPFTRMNMNELIFLLVSK-CSP---GDVTNPL---C---DY 553
            .......|:|.:.|..|||.:.:            :.:..|: |.|   |.::.||   |   :|
Human   407 IHRPCLQVIEAVLVAAVTATVAF------------VLIYSSRDCQPLQGGSMSYPLQLFCADGEY 459

  Fly   554 KRMNI----TSGNSFIEVTEPGPGVYSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAI 614
            ..|..    |...|.:.:....||.|:.:.|.:.|.:. ..|..:|:|:.|.||:||||||:||.
Human   460 NSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVY-FFLACWTYGLTVSAGVFIPSLLIGAA 523

  Fly   615 MGRIVGIGVEQFAYSYPNIWFFTGEC--ADSNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFEL 677
            .||:.||.:.          :.||..  ||     ||.||::||||.|||:.|||:||.|||.|.
Human   524 WGRLFGISLS----------YLTGAAIWAD-----PGKYALMGAAAQLGGIVRMTLSLTVIMMEA 573

  Fly   678 TGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEEF-AHTTLAADVMQP---- 737
            |..|.|..|:|...|.:|.|||.. .:|:||.||.|...|||..:... :|:..|.:||..
Human   574 TSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTC 637

  Fly   738 -KRNETLNVITQDSMTVDDVENLLKET--EHNGYPVVVSRENQY---LVGFVLRRDLNLAIGNAK 796
             :|.|.:.||.          ::|.:|  .|||:|||...::..   |.|.:||..| :.:...|
Human   638 LRRREKVGVIV----------DVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQL-IVLLKHK 691

  Fly   797 RLIE----GISSSSIVL------FTSSQPIQNLGPQ------PLKLKKILDMAPITVTDQTPMET 845
            ..:|    |:....:.|      :....|||::...      .:.|.:.::.:|.||..:..:..
Human   692 VFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPR 756

  Fly   846 VVDMFRKLGLRQTLVTHN-GRLLGVITKKDVLRH 878
            |..:||.||||..:|..| .:::|::|:||:.|:
Human   757 VFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARY 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	183/553 (33%)
		Voltage_CLC	298..699	CDD:279048	156/447 (35%)
		CBS	738..876	CDD:223591	41/159 (26%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	40/158 (25%)
CLCN7	NP_001278.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		ClC_6_like	95..620	CDD:239657	187/566 (33%)
		Selectivity filter part_1. /evidence=ECO:0000250	203..207		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	245..249		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	512..516		2/3 (67%)
		CBS_pair_voltage-gated_CLC_euk_bac	626..790	CDD:341367	44/174 (25%)
		CBS repeat	632..740	CDD:341367	25/118 (21%)
		CBS repeat	746..789	CDD:341367	15/42 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810