DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-c and CLCN6

DIOPT Version :9

Sequence 1:NP_001261922.1 Gene:ClC-c / 39759 FlyBaseID:FBgn0036566 Length:893 Species:Drosophila melanogaster
Sequence 2:NP_001277.2 Gene:CLCN6 / 1185 HGNCID:2024 Length:869 Species:Homo sapiens


Alignment Length:943 Identity:246/943 - (26%)
Similarity:379/943 - (40%) Gaps:331/943 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   146 LSFYGSSDVQDD--IPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGSIDAGSGW 208
            |:..|.:..::|  :|    .:|:.::|:.|.|....:.....:..::...::.:|        |
Human    29 LTILGETQEEEDEILP----RKDYESLDYDRCINDPYLEVLETMDNKKGRRYEAVK--------W 81

  Fly   209 LCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTWPE 273
            :.|..:|:..|.|...||......:.||.|:...:.    |:|         .:..|...... |
Human    82 MVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSV----EEC---------SQKGCLALSLL-E 132

  Fly   274 IFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKW 338
            :.|.:                  |.|..| |||:.:..|.|.||||||:|..|:|..:.|.:...
Human   133 LLGFN------------------LTFVFL-ASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLR 178

  Fly   339 TLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIG---NIFSHV--------FPKYGRNEAKKREIL 392
            |||.|.:|::.||:.||.:.|||||:|..|.:|   ..|..:        || |.|::..||:.:
Human   179 TLLCKVLGVLFSVAGGLFVEKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFP-YFRSDRDKRDFV 242

  Fly   393 SAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVL---RSLTPFGNEHS-- 452
            ||.|||||:.||||||||.||||||.|.::.....|:..||::.|.|.|   ||...||:..|  
Human   243 SAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQ 307

  Fly   453 ---VLFFVEYN--------KPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQYP- 505
               :|.|.|:.        ..|...:|..||.:|::||::|..|...|.   |..|:.....:| 
Human   308 LPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNK---RLAKYRMRNVHPK 369

  Fly   506 -----VMEVLFVTLVTAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITS--GN- 562
                 |:|.|.|:|||.::.:           :..:::.:|            ::|:.:|  || 
Human   370 PKLVRVLESLLVSLVTTVVVF-----------VASMVLGEC------------RQMSSSSQIGND 411

  Fly   563 SF-IEVTE-----------PG------------------------PGVYSSIWLLMLTFILKLAL 591
            || ::|||           |.                        .|.:|.: .|.|.|:|...|
Human   412 SFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPV-TLALFFVLYFLL 475

  Fly   592 TIFTFGMKVPAGLFIPSLLLGAIMGRIV--------GIGVEQFAYSYPNIWFFTGECADSNLITP 648
            ..:|:|:.||:|||:||||.||..||:|        |:|   ..||                   
Human   476 ACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLG---HIYS------------------- 518

  Fly   649 GLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIAL 713
            |.:|::||||.||||.|||:||.||:.|.|..:.|.:|:|...|.:||.||...: ||||.|:.|
Human   519 GTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNK-GIYDIHVGL 582

  Fly   714 NGYPFLDSKEEFAHTTL-AADVMQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQ 777
            .|.|.|:.:.|.....| |:|:|:|  |.|   .......:..:.::|:.|.|:.:|||.  ||:
Human   583 RGVPLLEWETEVEMDKLRASDIMEP--NLT---YVYPHTRIQSLVSILRTTVHHAFPVVT--ENR 640

  Fly   778 YLVGFVLRRDLNLAIGNAKRLIEG---IS--------------------SSSIVLFTSSQ----- 814
                           ||.|..::|   ||                    |.|:..:.||:     
Human   641 ---------------GNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRSQSMKSYPSSELRNMC 690

  Fly   815 -------------------------PIQNLGP--------------------------------- 821
                                     |..||.|                                 
Human   691 DEHIASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLLV 755

  Fly   822 -------------QP------------------------LKLKKILDM------APITVTDQTPM 843
                         ||                        |..:.|:|:      :|.||:..|.:
Human   756 RGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHV 820

  Fly   844 ETVVDMFRKLGLRQ-TLVTHNGRLLGVITKKDV 875
            ..|.::||.:|||. .:|...|.::|:||:.::
Human   821 SQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNL 853

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-cNP_001261922.1 ClC_3_like 215..719 CDD:239656 184/583 (32%)
Voltage_CLC 298..699 CDD:279048 160/480 (33%)
CBS 738..876 CDD:223591 44/268 (16%)
CBS_pair_EriC_assoc_euk_bac 741..878 CDD:239964 43/265 (16%)
CLCN6NP_001277.2 ClC_6_like 49..588 CDD:239657 190/630 (30%)
Selectivity filter part_1. /evidence=ECO:0000250 156..160 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 198..202 2/3 (67%)
Selectivity filter part_3. /evidence=ECO:0000250 487..491 3/3 (100%)
CBS_pair_voltage-gated_CLC_euk_bac 600..856 CDD:341367 48/276 (17%)
CBS repeat 606..806 CDD:341367 30/221 (14%)
CBS repeat 812..855 CDD:341367 14/42 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155005
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0038
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000220
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.740

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