| Sequence 1: | NP_001261922.1 | Gene: | ClC-c / 39759 | FlyBaseID: | FBgn0036566 | Length: | 893 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001821.2 | Gene: | CLCN4 / 1183 | HGNCID: | 2022 | Length: | 760 | Species: | Homo sapiens |
| Alignment Length: | 759 | Identity: | 463/759 - (61%) |
|---|---|---|---|
| Similarity: | 585/759 - (77%) | Gaps: | 12/759 - (1%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 144 GALSFYGSSDVQD----DIPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGSIDA 204
Fly 205 GSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEE-GNCSTW 268
Fly 269 KTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRG 333
Fly 334 YLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPKYGRNEAKKREILSAAAAA 398
Fly 399 GVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEHSVLFFVEYNKPW 463
Fly 464 IFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQYPVMEVLFVTLVTAIICYPNPFTRM 528
Fly 529 NMNELIFLLVSKCSPGDVTNPLCDY-KRMNITSGNSFIEVTEPGPGVYSSIWLLMLTFILKLALT 592
Fly 593 IFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGEC-ADSNLITPGLYAVVGA 656
Fly 657 AAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDS 721
Fly 722 KEEFAHTTLAADVMQPKRNE-TLNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLR 785
Fly 786 RDLNLAIGNAKRLIEGISSSSIVLFTSSQP-IQNLGPQPLKLKKILDMAPITVTDQTPMETVVDM 849
Fly 850 FRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQMDNEDPNTVLFN 893 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| ClC-c | NP_001261922.1 | ClC_3_like | 215..719 | CDD:239656 | 315/506 (62%) |
| Voltage_CLC | 298..699 | CDD:279048 | 266/402 (66%) | ||
| CBS | 738..876 | CDD:223591 | 87/139 (63%) | ||
| CBS_pair_EriC_assoc_euk_bac | 741..878 | CDD:239964 | 88/138 (64%) | ||
| CLCN4 | NP_001821.2 | Required for localization in the endoplasmic reticulum. /evidence=ECO:0000269|PubMed:17023393 | 14..63 | 23/48 (48%) | |
| ClC_3_like | 78..584 | CDD:239656 | 315/506 (62%) | ||
| Selectivity filter part_1. /evidence=ECO:0000250 | 180..184 | 3/3 (100%) | |||
| Selectivity filter part_2. /evidence=ECO:0000250 | 222..226 | 3/3 (100%) | |||
| Selectivity filter part_3. /evidence=ECO:0000250 | 467..471 | 3/3 (100%) | |||
| CBS_pair_voltage-gated_CLC_euk_bac | 595..745 | CDD:341367 | 95/149 (64%) | ||
| CBS repeat | 601..696 | CDD:341367 | 52/94 (55%) | ||
| Required for localization in the endoplasmic reticulum. /evidence=ECO:0000269|PubMed:28972156 | 667..696 | 13/28 (46%) | |||
| CBS repeat | 702..744 | CDD:341367 | 34/41 (83%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165155004 | |
| Domainoid | 1 | 1.000 | 544 | 1.000 | Domainoid score | I258 |
| eggNOG | 1 | 0.900 | - | - | E1_COG0038 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 966 | 1.000 | Inparanoid score | I326 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG55339 | |
| OrthoDB | 1 | 1.010 | - | - | D116173at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000220 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41248 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100336 | |
| Panther | 1 | 1.100 | - | - | O | PTHR45711 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R1878 |
| SonicParanoid | 1 | 1.000 | - | - | X829 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 15 | 14.800 | |||||