DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-c and CLCN3

DIOPT Version :9

Sequence 1:NP_001261922.1 Gene:ClC-c / 39759 FlyBaseID:FBgn0036566 Length:893 Species:Drosophila melanogaster
Sequence 2:NP_776297.2 Gene:CLCN3 / 1182 HGNCID:2021 Length:866 Species:Homo sapiens


Alignment Length:834 Identity:483/834 - (57%)
Similarity:609/834 - (73%) Gaps:56/834 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 SLTAAGTDDEDMIDITPRSSPGDVIGGGGGGGSSSGYHRETATESDTERDFGHSGGNGGGNHHNQ 125
            |:|:| :.||:::|               |.|....:.   .:|.|...|    |....|.|:. 
Human    18 SITSA-SSDEELLD---------------GAGVIMDFQ---TSEDDNLLD----GDTAVGTHYT- 58

  Fly   126 RTMHQHVPTHSAFGDPMDGALSFYGSS---DVQDD-IPGIGQYEDFHTIDWQRDIARDRMRHRYI 186
                            |....|...|:   |:.|: |||:|.|:|||||||.|:..:||.|||.|
Human    59 ----------------MTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRI 107

  Fly   187 VKKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQC 251
            ..|:::|.|::.|...||.||||.|.|.|:|:|.:||::||.|.||:|||.|||..|.|:|.|||
Human   108 NSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQC 172

  Fly   252 CYPAKQSVFEE-GNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYAC 315
            |:.:.::.||| ..|..||||.|:......|.|.||:.||.|:.|||.||.|:.|||::||||||
Human   173 CWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYAC 237

  Fly   316 GSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPK 380
            |||||||||||||||||||||||||:||::.|:|:|::||:||||||:||:|.|.|||||::|||
Human   238 GSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPK 302

  Fly   381 YGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLT 445
            |..|||||||:||||:||||||||||||||||||||||||||||||||||||.||:|||||||:.
Human   303 YSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSIN 367

  Fly   446 PFGNEHSVLFFVEYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQYPVMEVL 510
            ||||...|||:|||:.||..|||.||:.||:.||:.|.|||:||:.|||.||.:|.|:|||:||:
Human   368 PFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVI 432

  Fly   511 FVTLVTAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKR-MNITSGNSFIEVTEPGPGV 574
            .|..:||:|.:|||:||:|.:|||..|.:.|.|.: ::.||||:. ||.:.....|.....|.||
Human   433 IVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLE-SSSLCDYRNDMNASKIVDDIPDRPAGIGV 496

  Fly   575 YSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGE 639
            ||:||.|.|..|.|:.:|:||||:|||:||||||:.:|||.||||||.|||.|| |.:.||...|
Human   497 YSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAY-YHHDWFIFKE 560

  Fly   640 CAD--SNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALG 702
            ..:  ::.|||||||:|||||.||||||||||||||:||||||:.||||||||.|.|||||||.|
Human   561 WCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFG 625

  Fly   703 RQGIYDAHIALNGYPFLDSKEEFAHTTLAADVMQPKRNE-TLNVITQDSMTVDDVENLLKETEHN 766
            |:|||:|||.||||||||:||||.|||||||||:|:||: .|.|:|||:|||||:||::.||.:|
Human   626 REGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYN 690

  Fly   767 GYPVVVSRENQYLVGFVLRRDLNLAIGNAKRLIEGISSSSIVLF---TSSQPIQNLGPQPLKLKK 828
            |:||::|:|:|.||||.|||||.:||.:|::..|||..||.|.|   |.|.|.::  |:||||:.
Human   691 GFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAES--PRPLKLRS 753

  Fly   829 ILDMAPITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQM 882
            ||||:|.||||.||||.|||:||||||||.||||||.:||:||||::|.|::|:
Human   754 ILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGIVLGIITKKNILEHLEQL 807

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
ClC-cNP_001261922.1 ClC_3_like 215..719 CDD:239656 327/507 (64%)
Voltage_CLC 298..699 CDD:279048 269/403 (67%)
CBS 738..876 CDD:223591 86/141 (61%)
CBS_pair_EriC_assoc_euk_bac 741..878 CDD:239964 85/140 (61%)