DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and CLCN1

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_000074.3	Gene:	CLCN1 / 1180	HGNCID:	2019	Length:	988	Species:	Homo sapiens

Alignment Length:	950	Identity:	231/950 - (24%)
Similarity:	362/950 - (38%)	Gaps:	291/950 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 FGHSGGNGGGNHHNQRTMHQHVPTHSAFGDPMDGALSFYGS-----SDVQDDIPGIGQYEDFHTI 170
            :|....|||..|   |......|.|:..      ....||.     ||.:.||....:.....|:
Human    33 YGLPSENGGLQH---RLRKDAGPRHNVH------PTQIYGHHKEQFSDREQDIGMPKKTGSSSTV 88

  Fly   171 DWQRDIARDRMRHRYIVKKRQDSLWDLIKGSI---DAGSGWLCVLLVGIAAGCVAGMVDIGASWM 232
            |     ::|...:    .|.||.:..|  |.:   ..|...:.::|:|:....|        ||.
Human    89 D-----SKDEDHY----SKCQDCIHRL--GQVVRRKLGEDGIFLVLLGLLMALV--------SWS 134

  Fly   233 SDLKHGICPPAF-W-FNREQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLW 295
            .|........|: | :.:.|...|.:..|        |.|:|                     |.
Human   135 MDYVSAKSLQAYKWSYAQMQPSLPLQFLV--------WVTFP---------------------LV 170

  Fly   296 ALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKE 360
            .:||::|...|:   :|.|.||||||:||||.|.:::.||.....:.|.|.|...:.:|:.:|||
Human   171 LILFSALFCHLI---SPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKE 232

  Fly   361 GPMVHIASCIGNI---FSHVF------PKYGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLE 416
            ||.|||||....:   |..||      |.|      ..:||:...|.||...||.|:||||||:|
Human   233 GPFVHIASICAAVLSKFMSVFCGVYEQPYY------YSDILTVGCAVGVGCCFGTPLGGVLFSIE 291

  Fly   417 EVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEH---SVLFFVEYNK--PWIFFELIPFVFLGI 476
            ..|.||.::..||.||.|..:|||.|.|..:..:.   :.||...:..  |:...||..|..:||
Human   292 VTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAAIGI 356

  Fly   477 MGGVIGTFFIKANLWWCRY---------RKFSKLGQYPVMEVL----FVTLVTAIICYPNPFTRM 528
            ..|::|..|:        |         ||...|.|:.....|    .||.|.|...:|....:.
Human   357 CCGLLGAVFV--------YLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGMGQF 413

  Fly   529 NMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIE-VTEPGPGVYSSIW---------LLML 583
            ...||:        |.:..:.|.|        .|:::: ..:|.....|::|         ::.|
Human   414 MAGELM--------PREAISTLFD--------NNTWVKHAGDPESLGQSAVWIHPRVNVVIIIFL 462

  Fly   584 TFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADSNL--I 646
            .|::|..::|....|.:|.|.|:|..:|||..||:||   |..|..:|:     |...|..:  |
Human   463 FFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVG---EIMAMLFPD-----GILFDDIIYKI 519

  Fly   647 TPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHI 711
            .||.|||:||||:.|.|:. |||..||.|||||.:.:|:|:|.|.:.:..|..:| :..:||:.|
Human   520 LPGGYAVIGAAALTGAVSH-TVSTAVICFELTGQIAHILPMMVAVILANMVAQSL-QPSLYDSII 582

  Fly   712 ALNGYPFLDS---KEEFAHTTLAADVMQPKRNETLNVITQD------SMTVDDVENLLKETEHNG 767
            .:...|:|..   .:...:|....|:|           .:|      |.|..::..||:.|....
Human   583 QVKKLPYLPDLGWNQLSKYTIFVEDIM-----------VRDVKFVSASYTYGELRTLLQTTTVKT 636

  Fly   768 YPVVVSRENQYLVGFVLRRDLNLAI--------------------------GNAKRLIEGISSS- 805
            .|:|.|:::..|:|.|.|.:|...:                          |.|:...||:..:
Human   637 LPLVDSKDSMILLGSVERSELQALLQRHLCPERRLRAAQEMARKLSELPYDGKARLAGEGLPGAP 701

  Fly   806 --------------------------SIVLFTSS------------------QP----------- 815
                                      |:.|..|:                  ||
Human   702 PGRPESFAFVDEDEDEDLSGKSELPPSLALHPSTTAPLSPEEPNGPLPGHKQQPEAPEPAGQRPS 766

  Fly   816 ---------------------------IQNLGPQPLKLKK-------------ILDMAPITVTDQ 840
                                       :.|:.|:.::..:             .:|.:|..:.:|
Human   767 IFQSLLHCLLGRARPTKKKTTQDSTDLVDNMSPEEIEAWEQEQLSQPVCFDSCCIDQSPFQLVEQ 831

  Fly   841 TPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVK 880
            |.:.....:|..|||....||..|:|.||:..:::.:.::
Human   832 TTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAIE 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	164/544 (30%)
		Voltage_CLC	298..699	CDD:279048	145/439 (33%)
		CBS	738..876	CDD:223591	39/265 (15%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	39/264 (15%)
CLCN1	NP_000074.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..92		6/31 (19%)
		ClC_1_like	131..592	CDD:239655	164/540 (30%)
		Selectivity filter part_1. /evidence=ECO:0000250	188..192		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	230..234		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	482..486		2/3 (67%)
		CBS_pair_SF	605..869	CDD:417695	41/274 (15%)
		CBS repeat	610..820	CDD:341358	25/209 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..764		5/50 (10%)
		CBS repeat	826..868	CDD:341358	12/41 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..988
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740