DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ClC-c and clcn6

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	XP_002937575.2	Gene:	clcn6 / 100496474	XenbaseID:	XB-GENE-990272	Length:	864	Species:	Xenopus tropicalis

Alignment Length:	823	Identity:	229/823 - (27%)
Similarity:	364/823 - (44%)	Gaps:	205/823 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 LSFYGSSDVQDD--IPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGSIDAGSGW 208
            |:..|.:..:|:  :|    .:|:.::|:.|.|:...:.....:..::...::.::        |
Frog    23 LTILGETHEEDEEILP----RKDYESLDYDRCISDPYLEVLESINYKRAWRYEAVR--------W 75

  Fly   209 LCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTWPE 273
            :.|..:|:..|.|...||......|..|:.:...:.    |:|         .|..|...... |
Frog    76 IMVFAIGVCTGLVGLFVDFFVQLFSRFKYRVVQGSV----EEC---------TERGCLALSLL-E 126

  Fly   274 IFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKW 338
            :.|.:                  |.|..: |:|..:..|.|.||||||||..|:|..:.|.:...
Frog   127 LLGFN------------------LTFTFI-ATLFVLIQPVAAGSGIPEIKCYLNGVKVPGVVRLR 172

  Fly   339 TLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGN--------IFSHV---FPKYGRNEAKKREIL 392
            ||:.|::|::..||.||.:||||||:|..:.:|.        .|..:   || |.|::..||:.:
Frog   173 TLVCKALGVLFGVSGGLFVGKEGPMIHSGAVVGAGLPQFQSISFQKIRFDFP-YFRSDRDKRDFV 236

  Fly   393 SAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVL---RSLTPFGNEHS-- 452
            ||.|||||:.||||||||.||||||.|.::.....|:..||::.|.|.|   ||...|.:..|
Frog   237 SAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFSSWGSFQ 301

  Fly   453 ---VLFFVEYNKP--------WIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFS-----KL 501
               :|.|.|:..|        |...:|..|:.:|:.||::|..|...|....:||..:     ||
Frog   302 LPGLLNFGEFKCPDADKKCHLWTVVDLAFFIIMGVTGGLLGATFNCLNKRLAKYRMKNVHPKPKL 366

  Fly   502 GQYPVMEVLFVTLVTAIICYPNPFTRMNMNELIFLLVSKC---SPGDVTNPLCDYKRMNITSGNS 563
            .:  |.|.|.::|||.:|.:           :..:::.:|   ||.:.:|.....:..:....||
Frog   367 VR--VFESLLISLVTTVIVF-----------VASMVLGECRELSPSNWSNTSLTVQVSSSEEVNS 418

  Fly   564 FIEVTEPGPGVYSSIWLLML----TFILKL--------------------ALTIFTFGMKVPAGL 604
            .|:........|:.:..|..    :.||:|                    .|:.:|:|:.||:||
Frog   419 SIKTFFCPNNTYNDMATLFFNPQESAILQLFHQDGTFSPVTLSFFCCMYFLLSCWTYGISVPSGL 483

  Fly   605 FIPSLLLGAIMGRIVGIGVEQF-AYSYPNIWFFTGECADSNLITPGLYAVVGAAAVLGGVTRMTV 668
            |:||||.||..||:|...::.: .:|:               |..|.:|::||||.||||.|||:
Frog   484 FVPSLLCGAAYGRLVANLLKSYLGFSH---------------IYSGTFALIGAAAFLGGVVRMTI 533

  Fly   669 SLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLD-SKEEFAHTTLAA 732
            ||.||:.|.|..:.|.:|:|...|.:||.||...: ||||.|:.|.|.|.|: ..||......|:
Frog   534 SLTVILIESTNEISYGLPIMITLMVAKWTGDFFNK-GIYDIHVELRGVPLLEWETEEEMDKLRAS 597

  Fly   733 DVMQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIGNAKR 797
            |:|:|  |.|   .......:..:.::|:.|.|:.:|||.  ||:               ||.|.
Frog   598 DIMEP--NLT---YVYPHTRIQSLVSILRTTAHHAFPVVT--ENR---------------GNEKE 640

  Fly   798 LIEG---IS--------------------SSSIVLFTSSQPIQNL------GPQPLKLKKILDMA 833
            .::|   ||                    |.|:..:.||: ::|:      ..:|::.:.:|...
Frog   641 FMKGNQLISNNIKFKKASILTRAGEQRKRSQSMKSYPSSE-LRNMCDEHIATEEPVEKEDMLQQM 704

  Fly   834 --------PITVTDQTPME--TVVDMFRKLG-----LRQTLVT 861
                    |....||:|.|  |:.:.||.|.     ||..|||
Frog   705 LERRYTPYPNLYPDQSPSEEWTMEERFRPLTFHGLILRSQLVT 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	175/563 (31%)
		Voltage_CLC	298..699	CDD:279048	151/460 (33%)
		CBS	738..876	CDD:223591	37/168 (22%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	36/165 (22%)
clcn6	XP_002937575.2	ClC_6_like	43..583	CDD:239657	180/610 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	595..851	CDD:341367	41/176 (23%)
		CBS repeat	601..801	CDD:341367	38/170 (22%)
		CBS repeat	807..850	CDD:341367
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910