DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ClC-c and clcn2

DIOPT Version :9

Sequence 1:NP_001261922.1 Gene:ClC-c / 39759 FlyBaseID:FBgn0036566 Length:893 Species:Drosophila melanogaster
Sequence 2:XP_002935192.2 Gene:clcn2 / 100488889 XenbaseID:XB-GENE-494657 Length:882 Species:Xenopus tropicalis


Alignment Length:819 Identity:220/819 - (26%)
Similarity:347/819 - (42%) Gaps:217/819 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 GSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAF-WFNREQCCYPAKQSVFEEGNCSTW 268
            |..|:.::|:|:....|        ||..|....||..|. |.                      
 Frog    82 GEDWIFLILLGLLMALV--------SWAMDFTIAICLQAHKWM---------------------- 116

  Fly   269 KTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRG 333
                 ..|||.|    ..:.|:.:|.:.::..:.||...::.||.|.||||||:||||.|.:::.
 Frog   117 -----YGGLDNN----VFLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKE 172

  Fly   334 YLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPKYG---RNEAKKREILSAA 395
            ||...|.:.|.:||..::.:||.||||||.||:||....:.|.:...:|   .||::..|:|:||
 Frog   173 YLTLKTFIAKVIGLTCALGSGLPLGKEGPFVHVASMCAALLSKLMSLFGGIYENESRNIEMLAAA 237

  Fly   396 AAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEH---SVLFFV 457
            .|.||...|.|||||||||:|..|.:|.::..||.||.|..:||:.|.|..:..:.   :.||..
 Frog   238 CAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWIKDEETITALFKT 302

  Fly   458 EY--NKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRY-RKFSKLGQYPVME-VLF---VTLV 515
            .:  :.|:...||..|..:||..|..|..|:..|.....: ||...:.::.:.: :||   |||:
 Frog   303 SFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVEFMRKQKTINRFLMKKRLLFPALVTLL 367

  Fly   516 TAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIW- 579
            .|.:.:|..|.:....:|        :..:....|.|    |.|.....|.......|: ||:| 
 Frog   368 VATLTFPPGFGQFMAGQL--------TQKETLVTLFD----NYTWAQQGISEDFAYRGI-SSVWK 419

  Fly   580 -------LLMLTFIL-KLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFF 636
                   :.::.||| |..::.....:.||.|.|:|..::||..||:||   |..|     .||.
 Frog   420 HPKANVFVTLVVFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVG---ESMA-----AWFP 476

  Fly   637 TGECADSNL--ITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGD 699
            .|...|.:.  |.||.||||||||:.|.||. |||..||:|||||.:.:|:|:|.|.:.:..|..
 Frog   477 DGIHTDGSTYRIVPGGYAVVGAAALSGAVTH-TVSTAVIVFELTGQISHILPVMIAVILANAVAQ 540

  Fly   700 ALGRQGIYDAHIALNGYPFLDS-----KEEFAHTTLAADVMQPKRN---ETLN------------ 744
            :| :..:||:.|.:...|:|..     :|::  .....|:|  .||   .|||            
 Frog   541 SL-QPSLYDSIIRIKKLPYLPELGWGHQEKY--NVRVEDIM--LRNIPFVTLNSKYRDLQELLTN 600

  Fly   745 --------VITQDSM----TVDDVENL---------------LKETEHNGYPVVVSRENQYLVGF 782
                    |.|.:||    ::|..:.|               |:|.|.:|     .::.:..|.|
 Frog   601 CHLKCLALVETAESMILLGSIDRSQLLSLLRFQLSSKRRLQQLRERESSG-----KKQTENSVRF 660

  Fly   783 VL--------------RRDLNLAIGNAKRLIEGI-------SSSSIVLFTS-------SQPIQ-- 817
            .:              |:.|..|:   |..:..:       |.:|:....|       |:|::  
 Frog   661 QITTEESTFSPPQGETRKPLKPAL---KHTLSSLTESPADDSDNSVTALKSIFCAKDFSEPLEVV 722

  Fly   818 ------------------NLG----------------------PQPLKLKKI-LDMAPITVTDQT 841
                              .||                      .:|:.|... :|.||..:.::|
 Frog   723 KDPASPSKKNKSRLKHRHRLGEDLDEIDTMTQSQILEWEEIQLEEPINLNNCKIDPAPFQLVERT 787

  Fly   842 PMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVK 880
            .:.....:|..||:....||..|||:|::|.:::.:.::
 Frog   788 SLHKAHTVFSLLGMDHAYVTSIGRLIGMVTLRELRKAIE 826

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-cNP_001261922.1 ClC_3_like 215..719 CDD:239656 169/528 (32%)
Voltage_CLC 298..699 CDD:279048 149/424 (35%)
CBS 738..876 CDD:223591 44/250 (18%)
CBS_pair_EriC_assoc_euk_bac 741..878 CDD:239964 42/246 (17%)
clcn2XP_002935192.2 ClC_1_like 84..561 CDD:239655 172/538 (32%)
CBS_pair_voltage-gated_CLC_euk_bac <774..824 CDD:341367 14/49 (29%)
CBS repeat 781..823 CDD:341367 11/41 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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