Protein Alignment ClC-c and clcnkb

DIOPT Version :9

• Sequence 1: NP_001261922.1
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: XP_031755485.1
• Gene: clcnkb / 100487225
• XenbaseID: XB-GENE-6049695
• Length: 828
• Species: Xenopus tropicalis
• Alignment Length: 817
• Identity: 200/817 - (24%)
• Similarity: 325/817 - (39%)
• Gaps: 252/817 - (30%)

  Fly   205 GSGWLCVLLVGIAAGCVAGMVDIGAS-------WMSDLKHGICPPAFWFNREQCCYPAKQSVFEE 262
            |..|:.:.|:||:...::..:|:..:       |:.|
 Frog    77 GEDWIFLFLLGISMATISFGLDVTIAKLQRANLWVYD---------------------------- 113

  Fly   263 GNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILS 327
                         .|||.   .|:..:.| ||:.:|....||.:.:..:|.|.||||||||..|.
 Frog   114 -------------ALDRY---RYLQYFSW-VLYHVLLMITSAGMAKYISPQAAGSGIPEIKVTLR 161

  Fly   328 GFIIRGYLGKWTLLIKSVGLMLSVSAGLT--LGKEGPMVHIASCIGNIFSHVFPKY---GRNEAK 387
            |.::..:....|.:.|.:|:..:::||.|  |||.||.||:|:.:......:..|.   ..|.::
 Frog   162 GVVLAEFFTLRTFIAKLIGVTCTLAAGSTIFLGKVGPFVHMATILATQLGRLMVKLVGAKENPSR 226

  Fly   388 KREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEH- 451
            |.|:|.|.||.||:..|.||:||||||:|..:.:|.::..||.||.|..||.:.|.|.....|.
 Frog   227 KYEMLVAGAAVGVACCFVAPVGGVLFSVEATATHFAVRNYWRGFFAATCAALMFRLLAVINREKE 291

  Fly   452 --SVLFF----VEYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSK-----LGQYP 505
              ::||.    ||:  |:...|.:.:..||::.|.:          .|.|....:     |..:|
 Frog   292 TVAILFSTNWRVEF--PFDLPEYLSYAILGVVCGCL----------CCVYLFLHRTTLLFLQNHP 344

  Fly   506 VMEVL----------FVTLVTAIICYPNPF------TRMNMNELIFLLVSKCS------------ 542
            .:..|          ||..|.|.|.:|:.|      ||:.|.|.:....:..:
 Frog   345 RISTLLRNNRMVYAAFVAWVLASITFPHGFGQYLGGTRLTMKEHLETFFNNITWGIEELSLGANI 409

  Fly   543 PGDVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIWLLMLTFILKLALTIFTFGMKVPAGLFIP 607
            .|...||         :..|:|::.|.|.   .|::.:|....:||..:.:|...|.:|||.|:|
 Frog   410 SGQPPNP---------SYSNNFLQWTHPN---MSTLEILTCFVVLKFFMLLFANTMIIPAGYFLP 462

  Fly   608 SLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADS--NLITPGLYAVVGAAAVLGGVTRMTVSL 670
            ..:.||.:||:.|   |..|..:||     |..::.  ..|||..||:.||||..|.||: |:|.
 Frog   463 VFVYGAGLGRLYG---EIMAKIFPN-----GIVSEGIPIKITPAGYALAGAAAYSGAVTQ-TLST 518

  Fly   671 VVIMFELTGGVRYIVPLMAAAMASKWVGDALG---RQGIYDAHIALNGYPFLDSKEEFAHTTLAA 732
            .:::|||:|.:.:|:|::.|.:    :.:|:.   :...:|..:.:...|:|
 Frog   519 ALLVFELSGQMSHILPVLIAVL----IANAISQNYQSSFFDLIVIIKKLPYL------------- 566

  Fly   733 DVMQPK----RNETLNVITQDSMTVD-----------DVENLLKETEHNGYPVVVSRENQYLVGF 782
                ||    :|...::..:|.|..|           |:.:|||.:|...:|.|.|.|::.|:|.
 Frog   567 ----PKLAMGQNSAHDICAEDFMVTDLQYLVKGFRYRDIRSLLKSSELKQFPFVDSEESKVLLGC 627

  Fly   783 VLRRDLNLAIGNAKRLIEGISSSSIVLFTSSQ-----PIQNLGPQ-------------------- 822
            ..|:.|      ||.|.|.:|:...:.|...:     ||...|..
 Frog   628 FSRKSL------AKLLAEQLSTERRIQFMLDKTGGKFPITPSGENGTDEKTDLHKIEECEYSDTT 686

  Fly   823 -------------------------------------------------PLKLKKILDMAPITVT 838
                                                             ||:|..| |..|..:.
 Frog   687 YSAQETVVYESEEKQKTRTESRRRRSAKFKSHYLKMVEEWECRQLNEEVPLELLTI-DPTPYRLL 750

  Fly   839 DQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDV 875
            ::..:....|:|..||||...||..|||:||::..::
 Frog   751 EKETLYQCYDLFNLLGLRTAYVTRIGRLVGVVSLSEI 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	149/560 (27%)
		Voltage_CLC	298..699	CDD:279048	134/447 (30%)
		CBS	738..876	CDD:223591	46/227 (20%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	44/220 (20%)
clcnkb	XP_031755485.1	ClC_1_like	79..567	CDD:239655	152/586 (26%)
		CBS_pair_voltage-gated_CLC_euk_bac	581..790	CDD:341367	44/214 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000