DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and clcn2a

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_001315638.1	Gene:	clcn2a / 100150892	ZFINID:	ZDB-GENE-070705-19	Length:	979	Species:	Danio rerio

Alignment Length:	905	Identity:	232/905 - (25%)
Similarity:	363/905 - (40%)	Gaps:	273/905 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 DGALSFYGSSDVQDDIPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGSIDAGSG 207
            ||.|.  .::.|:...|.:.:||.......|  :...|.: ::::.:              .|..
Zfish    40 DGGLR--RTTSVRGQAPELLEYEKDPCAKCQ--VCTSRCK-KFLISR--------------VGED 85

  Fly   208 WLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPA-FWFNREQCCYPAKQSVFEEGNCSTWKTW 271
            |:.::|:|:....|        ||..|.....|..| .|..|
Zfish    86 WIFLILLGLLMALV--------SWAMDYTIAFCQQAQKWMYR----------------------- 119

  Fly   272 PEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLG 336
                ||..|    .::.|:.:|.:.::..:.||...::.||.|.||||||:||||.|.:::.||.
Zfish   120 ----GLHSN----MLLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLT 176

  Fly   337 KWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPKYG-----------RNEAKKRE 390
            ..|.:.|.:||..::.:|:.||||||.||:||....:.|.....:|           :||.:..|
Zfish   177 FKTFVAKVIGLTCALGSGMPLGKEGPFVHVASLCAALLSKFMALFGGIYMEEPFEGNKNELRNTE 241

  Fly   391 ILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEH---S 452
            :||||.|.||...|.|||||||||:|..|.:|.::..||.||.|..:||:.|.|..:..:.   :
Zfish   242 MLSAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNKDEETIT 306

  Fly   453 VLFFVEY--NKPWIFFELIPFVFLGIMGGVIGTFFIKAN---LWWCRYRK------FSKLGQYPV 506
            .||...:  :.|:...||..|..|||..|..|..::..|   :...|.:|      ..|...||.
Zfish   307 ALFKTRFRLDFPFDLQELPAFAVLGIASGFGGALYVYLNRIIVESMRKQKTINKFLLKKRLVYPA 371

  Fly   507 MEVLFVTLVTAIICYPNPF-----TRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSG----- 561
            :    |||:.:.:.:|..|     .::..:|.:..|...         |..||:     |
Zfish   372 V----VTLLISTLTFPPGFGQFMAGQLTQHESLVALFDN---------LTWYKQ-----GVAEEF 418

  Fly   562 --NSFIEVTEPGPGVYSSIWLLMLTFI-LKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGV 623
              :|.:......|.|  |:::.:|.|| :|..::.....|.||.|.|:|..|:||..||:||
Zfish   419 EYSSHVPQAWKHPQV--SVFITLLLFIVMKFWMSAVATTMPVPCGAFMPVFLIGAAFGRLVG--- 478

  Fly   624 EQFAYSYPNIWFFTGECADSNL--ITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVP 686
            |..|..:|:     |..|||.:  |.||.||||||||:.|.||. |||..||:|||||.:.:|:|
Zfish   479 ESMAAFFPD-----GIHADSTVYPIVPGGYAVVGAAALSGAVTH-TVSTAVIVFELTGQISHILP 537

  Fly   687 LMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEEFAHTTLAADVMQPK---RNETLNVITQ 748
            :|.|.:.:..|..:| :..:||:.|.:...|:|                 |:   ..|..|:..:
Zfish   538 VMIAVILANAVAQSL-QPSLYDSIIRIQKLPYL-----------------PELGWGQEKYNIRVE 584

  Fly   749 DSMTVD-----------DVENLLKETEHNGYPVVVSRENQYLVGFVLRRD----LNLAIGNAKR- 797
            |.|..|           |::..|...:.....:|.|:|:..|:|.:.|..    |:..:|..:|
Zfish   585 DIMVRDVRYITLSSSYRDLQEALVTGQLKTLALVESKESMILLGSIERSQLQSLLSQQLGRPRRL 649

  Fly   798 -------------------------------LIEGISSSSIVLFTSSQ----------------- 814
                                           ||....||.....|:||
Zfish   650 EYLRERAQDNGTHVPTFTPDSPPKAGRGVRFLISTEESSYSPTLTNSQIPLKSALKTVSAISNTD 714

  Fly   815 ------------PIQ-----NLGP-------QPLKLK---------------------------- 827
                        |::     |.||       :|.::|
Zfish   715 SLNSSPNLSCGEPVKELVESNAGPMAPKRSRRPKRVKIPMADTADVEDDMSTAEIAEWEEQQLDE 779

  Fly   828 -------KILDMAPITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVK 880
                   || |.||..:.::|.:.....:|..|||....||..|||:||::.|::.:.::
Zfish   780 AVNFNNCKI-DPAPFQLVERTSLHKTHTIFSLLGLDHAYVTSTGRLVGVVSLKELRKAIE 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	171/544 (31%)
		Voltage_CLC	298..699	CDD:279048	152/440 (35%)
		CBS	738..876	CDD:223591	47/263 (18%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	47/259 (18%)
clcn2a	NP_001315638.1	ClC_1_like	85..571	CDD:239655	174/571 (30%)
		Voltage_CLC	138..550	CDD:279048	152/440 (35%)
		CBS_pair_EriC_assoc_euk_bac	<788..836	CDD:239964	17/48 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590029
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740