DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5235 and moxd1

DIOPT Version :9

Sequence 1:	NP_001261921.1	Gene:	CG5235 / 39758	FlyBaseID:	FBgn0036565	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	XP_005160648.1	Gene:	moxd1 / 570584	ZFINID:	ZDB-GENE-030131-9320	Length:	614	Species:	Danio rerio

Alignment Length:	677	Identity:	209/677 - (30%)
Similarity:	330/677 - (48%)	Gaps:	114/677 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 WVRNEMMDSLGLYWLKWWINANENSIYFEVTVHTRGFAGLGFSKDGRLARADMVLMWVDDATGHP 108
            :|.:..:|:...|.:||  ..:|::|.||:.|.|||:.|.|.|..|.::.:|:|:..|  ..|.|
Zfish    27 FVHSAALDAERRYNIKW--GFDESTITFEIEVETRGYVGFGLSPTGAMSSSDIVIGGV--LNGSP 87

  Fly   109 NVL----DCHGALHPSSGPPLQDDTQNYDVLDGKQNGTHTILKFKRKIETCDPFDIPLSADTFKV 169
            .:|    |.:..:|       :|..|||::|.|::|.|||:|.|.|.::|||..|..::..|.:|
Zfish    88 YLLDYFTDSNRKVH-------RDPLQNYELLYGRENDTHTVLAFSRNLQTCDDNDKIITGSTVRV 145

  Fly   170 LWSIGENDPIHGNLDWQGQSRGVKALQLFSPMFTKNSHSI-EGIQKWDITVNNVTIDRSMDTLYW 233
            :|:....|.....|.:.|.:||.|:|:|.:|   ....|| .|...:|:....|.:... ||.||
Zfish   146 IWAFHAEDVGESGLVYHGMNRGRKSLRLLNP---GTGPSIPAGTAFFDLQNKEVPVPHK-DTTYW 206

  Fly   234 CKIVRLPELTGKQHIIGYEPLLSGKYERNVVHHMTLFECQSKIYSGSDPSSWDLWVRSAGTVC-N 297
            |:|.|.||:..|.|:|..|||:...:| |:|||:.|::|.|.:....         .:.|..| :
Zfish   207 CQIFRFPEMKKKHHVIRIEPLIQKGHE-NLVHHILLYQCDSNLNKSE---------VNRGHECYH 261

  Fly   298 SNLLTPRDWDSCSTPVAVWSLGSDGQFLPPHAGIPMGGASGVSYYMLEIHYDNPDGKES-VDHSG 361
            .|:  |..:.:|.|.:..|::|.:|...|||.|:.:|.:....|..||||:|||..:.. ||.||
Zfish   262 PNM--PDSFLTCETVLFAWAIGGEGFTYPPHVGMSIGTSIDPVYVQLEIHFDNPSLQGGIVDSSG 324

  Fly   362 FRIHYTPNLRTYDSGILISGVSISETQLIPPGQKKYRSVGICGPSCSSVMFPKD---GIKIISGT 423
            .|::|:|:||.||:|::.:||.:|...::|||...|.:.|.|...|.......:   |:.:.:..
Zfish   325 LRLYYSPSLRRYDAGVIETGVWVSLYHMLPPGMTDYITEGHCTQECLQESLDSEMPSGVHVFAVL 389

  Fly   424 LHSHQAGRTISLRHVRSGKELNPIIVDENYDYRHQKVHQLANETVVLPGDYLITDCSYETKYRKR 488
            ||:|.|||.|:.||.|...||.|:..|:.:|:..|:...|:.|.::||||.|||:|.|.||.|..
Zfish   390 LHAHLAGRAITARHFRQQLELQPLASDDQFDFNFQEFQPLSQERLILPGDSLITECRYNTKGRMN 454

  Fly   489 PTFGGYSTKEEMCLTFITYYPKIEMSGCYSMTPVREFFEMFRVYQFYSLNMTDVENMFLYNSDYT 553
            .|:||.||:|||||:|:.|||::.::.|.|:..:        ..|...:.:|:::
Zfish   455 MTWGGLSTREEMCLSFLLYYPRVNLAKCESLPEI--------AGQLKFIGVTEIQ---------- 501

  Fly   554 DYSKQAKNATNKPNSGKTSKEDVIYQESLLNKLVISDPAEFHDRTFLSHLNQLPWHDPLFTKRVE 618
                  :..|..|                   .||..|.::.:.:|...:::..|     |.:..
Zfish   502 ------EPVTTWP-------------------FVIKSPKKYSNLSFTEAMDKYKW-----TMKKG 536

  Fly   619 QAF--ITGTHMTFCRVSK---DSLSIPSEIIRYPEF------TAYVKPPAACLNYLFTDNEELRS 672
            ::|  |........|.||   |..||...|:..||.      ||.|    ||..
Zfish   537 KSFNDIVRKLPMNVRCSKTGQDEWSIQGMIVSPPEVRSEQTSTAVV----ACRK----------- 586

  Fly   673 GSSQFFTDFTLSLLL--LIQLGLQTTL 697
             .|....:.:|:|||  .:.|.|||.|
Zfish   587 -DSAIQCEHSLALLLTACLLLILQTCL 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5235	NP_001261921.1	DOMON	54..174	CDD:281361	43/123 (35%)
		Cu2_monooxygen	214..354	CDD:279429	47/140 (34%)
		Cu2_monoox_C	374..529	CDD:281675	59/157 (38%)
moxd1	XP_005160648.1	DOMON_DOH	31..167	CDD:187689	47/146 (32%)
		Cu2_monooxygen	188..316	CDD:279429	47/140 (34%)
		Cu2_monoox_C	337..484	CDD:281675	58/146 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592018
Domainoid	1	1.000	131	1.000	Domainoid score	I5127
eggNOG	1	0.900	-	-		E1_KOG3568
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2566
OMA	1	1.010	-	-		QHG59784
OrthoDB	1	1.010	-	-		D1472750at2759
OrthoFinder	1	1.000	-	-		FOG0002519
OrthoInspector	1	1.000	-	-		otm25003
orthoMCL	1	0.900	-	-		OOG6_101678
Panther	1	1.100	-	-	O	PTHR10157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4667
SonicParanoid	1	1.000	-	-		X2216
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800