Protein Alignment CG5235 and MOXD1

DIOPT Version :10

• Sequence 1: NP_648833.1
• Gene: CG5235 / 39758
• FlyBaseID: FBgn0036565
• Length: 698
• Species: Drosophila melanogaster
• Sequence 2: NP_056344.2
• Gene: MOXD1 / 26002
• HGNCID: 21063
• Length: 613
• Species: Homo sapiens
• Alignment Length: 665
• Identity: 208/665 - (31%)
• Similarity: 326/665 - (49%)
• Gaps: 88/665 - (13%)

  Fly    42 KNWVRNEMMDSLGLYWLKWWINANENSIYFEVTVHTRGFAGLGFSKDGRLARADMVLMWVDDATG 106
            :.:....::||.|.|||.|  :...:.|.|.:.|.|.|:.|.|||..|.:|.||:|:..|  |.|
Human    23 RTYPHRTLLDSEGKYWLGW--SQRGSQIAFRLQVRTAGYVGFGFSPTGAMASADIVVGGV--AHG 83

  Fly   107 HPNVLDCHGALHPSSGPPLQDDT-QNYDVLDGKQNGTHTILKFKRKIETCDPFDIPLSADTFKVL 170
            .|.:.|    ...::...|:.|. |:|.:....:|.||||::|.|::.|||..|..::..|.:|:
Human    84 RPYLQD----YFTNANRELKKDAQQDYHLEYAMENSTHTIIEFTRELHTCDINDKSITDSTVRVI 144

  Fly   171 WSIGENDPIHGNLDWQGQSRGVKALQLFSPMFTKNSHSIEGIQKWDITVNNVTIDRSMDTLYWCK 235
            |:....|.......:...:||.|:|:|.:|  .|.|.....:..:|:...:|.|. :.||.|||:
Human   145 WAYHHEDAGEAGPKYHDSNRGTKSLRLLNP--EKTSVLSTALPYFDLVNQDVPIP-NKDTTYWCQ 206

  Fly   236 IVRLPELTGKQHIIGYEPLLSGKYERNVVHHMTLFECQSKIYSGSDPSSWDLWVRSAGTVC-NSN 299
            :.::|....|.|:|..||::...:| ::|||:.|::|.:.....         |..:|..| :.|
Human   207 MFKIPVFQEKHHVIKVEPVIQRGHE-SLVHHILLYQCSNNFNDS---------VLESGHECYHPN 261

  Fly   300 LLTPRDWDSCSTPVAVWSLGSDGQFLPPHAGIPMGGASGVSYYMLEIHYDNPDGKES-VDHSGFR 363
            :  |..:.:|.|.:..|::|.:|...|||.|:.:|......|.:||:|||||..:|. :|:||.|
Human   262 M--PDAFLTCETVIFAWAIGGEGFSYPPHVGLSLGTPLDPHYVLLEVHYDNPTYEEGLIDNSGLR 324

  Fly   364 IHYTPNLRTYDSGILISGVSISETQLIPPGQKKYRSVGICGPSCSSVMFPKD---GIKIISGTLH 425
            :.||.::|.||:|::.:|:.:|....||||..:::|.|.|...|.......:   ||.:.:..||
Human   325 LFYTMDIRKYDAGVIEAGLWVSLFHTIPPGMPEFQSEGHCTLECLEEALEAEKPSGIHVFAVLLH 389

  Fly   426 SHQAGRTISLRHVRSGKELNPIIVDENYDYRHQKVHQLANETVVLPGDYLITDCSYETKYRKRPT 490
            :|.|||.|.|||.|.|||:..:..|:::|:..|:...|..|..:||||.|||:|.|.||.|...|
Human   390 AHLAGRGIRLRHFRKGKEMKLLAYDDDFDFNFQEFQYLKEEQTILPGDNLITECRYNTKDRAEMT 454

  Fly   491 FGGYSTKEEMCLTFITYYPKIEMSGCYSMTPVREFFEMFRVYQFYSLNMTDVENMFLYNSDYTDY 555
            :||.||:.||||:::.|||:|.::.|.|:..:.|..:...|.:.|....|   ..|:..|
Human   455 WGGLSTRSEMCLSYLLYYPRINLTRCASIPDIMEQLQFIGVKEIYRPVTT---WPFIIKS----- 511

  Fly   556 SKQAKNATNKPNSGK---TSKEDVIYQESLLNKLVISDPAEFHDRTFLSHLNQLPWHDPLFTKRV 617
            .||.||.:......|   |.||.:.:     ||||:|.|....    .|..:...|.
Human   512 PKQYKNLSFMDAMNKFKWTKKEGLSF-----NKLVLSLPVNVR----CSKTDNAEWS-------- 559

  Fly   618 EQAFITGTHMTFCRVSKDSLSIPSEIIRYPEFTAYVKPPAACLNYLFTDNEELRSGSSQFFTDFT 682
                |.|  ||         ::|.:|.|     .|...|..|..          |.||....||:
Human   560 ----IQG--MT---------ALPPDIER-----PYKAEPLVCGT----------SSSSSLHRDFS 594

  Fly   683 LSLLLLIQLGLQTTL 697
            ::||:.:.| |..||
Human   595 INLLVCLLL-LSCTL 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5235	NP_648833.1	DOMON	56..173	CDD:460893	41/117 (35%)
		Cu2_monooxygen	215..355	CDD:460053	43/140 (31%)
		Cu2_monoox_C	373..529	CDD:461021	62/158 (39%)
MOXD1	NP_056344.2	DOMON_DOH	29..165	CDD:187689	45/143 (31%)
		Cu2_monooxygen	187..312	CDD:460053	42/137 (31%)
		Cu2_monoox_C	334..482	CDD:461021	60/147 (41%)