DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5235 and Dbh

DIOPT Version :9

Sequence 1:	NP_001261921.1	Gene:	CG5235 / 39758	FlyBaseID:	FBgn0036565	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_037290.3	Gene:	Dbh / 25699	RGDID:	2489	Length:	621	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	150/482 - (31%)
Similarity:	236/482 - (48%)	Gaps:	42/482 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MDSLGLYWLKWWINANENSIYFEVTVH-TRGFAGLGFSKDGRLARADMVLMWVD-DATGHPNV-L 111
            :|..|...|.|.::.::..|:|::.|. .|.....|.|..|.:..||:|::|.| |.|...:. .
  Rat    56 LDPEGTLELSWNVSYDQEIIHFQLQVQGPRAGVLFGMSDRGEMENADLVMLWTDGDRTYFADAWS 120

  Fly   112 DCHGALHPSSGPPLQDDTQNYDVLDGKQNGTHTILKFKRKIETCDPFDIPLSADTFKVLWSIGEN 176
            |..|.:|       .|..|:|.:|..::......|.|||...||||.|..:..||..:::.|.|
  Rat   121 DQKGQIH-------LDTHQDYQLLQAQRVSNSLSLLFKRPFVTCDPKDYVIEDDTVHLVYGILE- 177

  Fly   177 DPIHG--NLDWQGQSRGVKALQLFSPMFTKNSHSIEGIQKWDITVNNVTIDRSMDTLYWCKIVRL 239
            :|...  .::..|...|::.:||..|..:..:...: :|..||...:|.|. |.:|.|||.|..|
  Rat   178 EPFQSLEAINTSGLHTGLQQVQLLKPEVSTPAMPAD-VQTMDIRAPDVLIP-STETTYWCYITEL 240

  Fly   240 PELTGKQHIIGYEPLLSGKYERNVVHHMTLFECQSK-----IYSGSDPSSWDLWVRSAGTVCNSN 299
            |....:.|||.||.:::...|. :||||.:|:|.::     :::|.               |:|.
  Rat   241 PLHFPRHHIIMYEAIVTEGNEA-LVHHMEVFQCTNESEAFPMFNGP---------------CDSK 289

  Fly   300 LLTPRDWDSCSTPVAVWSLGSDGQFLPPHAGIPMGGASGVSYYMLEIHYDNP---DGKESVDHSG 361
             :.|...:.|...:|.|:||:...:.|..||:|.||:....:..||:||.||   .|:.  |.||
  Rat   290 -MKPDRLNYCRHVLAAWALGAKAFYYPEEAGVPFGGSGSSRFLRLEVHYHNPRNIQGRR--DSSG 351

  Fly   362 FRIHYTPNLRTYDSGILISGVSISETQLIPPGQKKYRSVGICGPSCSSVMFPKDGIKIISGTLHS 426
            .|:|||.:||..::||:..|:..:....|||.:..:...|.|...|:.:..||.||:|.:..||:
  Rat   352 IRLHYTASLRPNEAGIMELGLVYTPLMAIPPQETTFVLTGYCTDRCTQMALPKSGIRIFASQLHT 416

  Fly   427 HQAGRTISLRHVRSGKELNPIIVDENYDYRHQKVHQLANETVVLPGDYLITDCSYETKYRKRPTF 491
            |..||.:.....|.|::...:..|.:|....|::..|.|...|..||.|||.|:|.|:.|...|.
  Rat   417 HLTGRKVITVLARDGQQREVVNRDNHYSPHFQEIRMLKNAVTVHQGDVLITSCTYNTENRTMATV 481

  Fly   492 GGYSTKEEMCLTFITYYPKIEMSGCYS 518
            ||:...||||:.::.||||.|:..|.|
  Rat   482 GGFGILEEMCVNYVHYYPKTELELCKS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5235	NP_001261921.1	DOMON	54..174	CDD:281361	35/122 (29%)
		Cu2_monooxygen	214..354	CDD:279429	45/147 (31%)
		Cu2_monoox_C	374..529	CDD:281675	50/145 (34%)
Dbh	NP_037290.3	DOMON	60..175	CDD:397434	35/121 (29%)
		Cu2_monooxygen	217..340	CDD:395859	43/140 (31%)
		Cu2_monoox_C	363..519	CDD:397669	50/146 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3568
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1472750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820