DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5235 and Moxd2

DIOPT Version :9

Sequence 1:	NP_001261921.1	Gene:	CG5235 / 39758	FlyBaseID:	FBgn0036565	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_647457.2	Gene:	Moxd2 / 194357	MGIID:	2388042	Length:	619	Species:	Mus musculus

Alignment Length:	560	Identity:	164/560 - (29%)
Similarity:	254/560 - (45%)	Gaps:	80/560 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 NEMMDSLGLYWLKWWINANENSIYFEVTVHTRGFAGLGFSKDGRLARADMVLMWVDDATGHPNVL 111
            :..:|.....:|:|..:.....|.||:.|.|.|:.|||.:.......:|:|:..|     .||
Mouse    33 SRFLDPSRAVFLRWDFDYEAEIITFELQVQTTGWVGLGITDRYTFVGSDLVVGGV-----LPN-- 90

  Fly   112 DCHGALHPSSGPPLQDDT------QNYDVLDGKQNGTHTILKFKRKIETCDPFDIPLSADTFKVL 170
               |.::.|....|.:||      |:.::|...::...|.::|.|...||||.|..:::||.:||
Mouse    91 ---GNVYFSDQHLLDEDTLEQDGSQDAELLRLTEDAVSTTMRFSRPFRTCDPHDRDITSDTMRVL 152

  Fly   171 WSIGEND-PIHGNLDWQGQSRGVKALQLFSPMFTKNSHSIEGIQKWDITVNNVTIDRSMDTLYWC 234
            .:.|.:| |     ....:...||::.|...:...:..:.|.....|:.::|..|... ||.|.|
Mouse   153 AAYGPDDIP-----KMSREHTFVKSIFLLQMLQYDDQDAPEDTIIHDLKISNFIIPED-DTTYAC 211

  Fly   235 KIVRLPELTGKQHIIGYEPLLSGKYERN--VVHHMTLFECQS---------KIYSGSDPSSWDLW 288
            ..:.||.::.|.||..:||:|   .|||  :|||:.::.|.:         :.| ||||:
Mouse   212 TFLPLPIVSKKHHIYKFEPIL---VERNETMVHHVLVYACGNSSVLPTGIGECY-GSDPA----- 267

  Fly   289 VRSAGTVCNSNLLTPRDWDSCSTPVAVWSLGSDGQFLPPHAGIPMGGASGVSYYMLEIHYDNPDG 353
                             :..||..:|.|::|......|...||.:|......:..|||||.|...
Mouse   268 -----------------FSLCSHVIAGWAVGGLSYQFPDDVGISIGTPFDPQWIRLEIHYSNFQN 315

  Fly   354 KESV-DHSGFRIHYTPNLRTYDSGILISGVSISETQLIPPGQKKYRSVGICGPSCSSVM--FPKD 415
            ...: |.||.|:.||.:||.||.|:|..|:|:.....||||.:.:.|.|:|.......:  .|..
Mouse   316 LPGIRDTSGMRLFYTSHLRKYDMGVLQLGISVFPIHFIPPGAEAFLSYGLCKTDKFEELNGAPVS 380

  Fly   416 GIKIISGTLHSHQAGRTISLRHVRSGKELNPIIVDENYDYRHQKVHQLANETVVLPGDYLITDCS 480
            .|.|.:..||:|.|||::.....|:|.:|..:..|.:||:..|:...|.:..|:.|||.|:.:|.
Mouse   381 DIYISACLLHTHLAGRSLQALQYRNGTQLQVVCKDFSYDFNLQESRDLPHPVVIKPGDELLIECH 445

  Fly   481 YETKYRKRPTFGGYSTKEEMCLTFITYYPKIEMSGCYSMTPVREFFEMFRVYQFYSLNMTDVEN- 544
            |:|..|...||||.||..||||.|..|||:|.:|.|.....:        :|....|.....||
Mouse   446 YQTLDRDFMTFGGASTINEMCLIFFFYYPRINISSCMGYPDI--------IYVTNELGEEASENP 502

  Fly   545 ----MFLYNSDYT-DYSKQAKNATNKPNSG---KTSKEDV 576
                |.|.|.::| :..|:|:.|..:....   ||..|:|
Mouse   503 MENLMVLDNVEWTPENIKKAEKACKESQQTVLIKTIDEEV 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5235	NP_001261921.1	DOMON	54..174	CDD:281361	35/125 (28%)
		Cu2_monooxygen	214..354	CDD:279429	42/150 (28%)
		Cu2_monoox_C	374..529	CDD:281675	55/156 (35%)
Moxd2	NP_647457.2	DOMON_DOH	36..172	CDD:187689	40/150 (27%)
		Cu2_monooxygen	194..314	CDD:279429	42/146 (29%)
		Cu2_monoox_C	337..482	CDD:281675	54/144 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846802
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3568
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59784
OrthoDB	1	1.010	-	-		D1472750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10157
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860