Protein Alignment CG5235 and tbh-1

DIOPT Version :10

• Sequence 1: NP_648833.1
• Gene: CG5235 / 39758
• FlyBaseID: FBgn0036565
• Length: 698
• Species: Drosophila melanogaster
• Sequence 2: NP_001257264.1
• Gene: tbh-1 / 181639
• WormBaseID: WBGene00006541
• Length: 657
• Species: Caenorhabditis elegans
• Alignment Length: 633
• Identity: 164/633 - (25%)
• Similarity: 263/633 - (41%)
• Gaps: 139/633 - (21%)

  Fly    58 LKW-------------WINANENSIYFEVTVHTRGFAGLGFSKDGRLARADMVLMWVDDATGHPN 109
            :||             |..|:...:.|           ||||..|....:| |||:.:   ....
 Worm   107 VKWHTDYERQLVDFSIWFGASTPDVLF-----------LGFSDFGDTNNSD-VLMYYN---SKKE 156

  Fly   110 VLDCHGALHPSSGPPLQDDTQNYDVLDGKQNGTHTILKFKRKIETCDPFDIPLSADT--FKVLWS 172
            :.|.:..........||.|.|..     ::...|.::  :||:.|||..|......|  |.:..|
 Worm   157 IKDAYTNRDFKITSDLQQDFQLL-----RKRKDHIVV--RRKLTTCDSRDYAFLPGTTQFYIAAS 214

  Fly   173 IGEND-----------------PIHGNLDWQGQSRGVKALQLFSPMFTKNSHSIEGIQKWDITVN 220
            .|..:                 .|.|..|.........||:....:...||:|.:.|.
 Worm   215 WGSTNLVDIRDKRWVVDKKFGKVIEGPTDQPNIEEEPAALEKDVKVVIVNSNSPDPIP------- 272

  Fly   221 NVTIDRSMDTLYWCKIVRLP--ELTGKQHIIGYEPLLSGKYERNVVHHMTLFECQSKI--YSGSD 281
                  :::|.|.|.|.::|  .:....|::..||.::...| ::||||.:|.|:.::  :|||
 Worm   273 ------NVETTYKCIIRKMPFDTVNNMYHVVRMEPYVTPGNE-HLVHHMEIFMCRDEVEEWSGS- 329

  Fly   282 PSSWDLWVRSAGTVCNSNLLTPRDWDSCSTPVAVWSLGSDGQFLPPHAGIPMGGASGVSYYMLEI 346
                          ||.....|:. .|||..:|.|::|......|..||:|:||....:|.|:||
 Worm   330 --------------CNDPKKPPKS-KSCSHVIAAWAMGEGPIHYPKEAGLPIGGKGKNAYVMVEI 379

  Fly   347 HYDNPD-GKESVDHSGFRIHYTPNLRTYDSGILISGVSISETQLIPPGQKKYRSVGICGPSCSSV 410
            ||:||: .|..:|.|||:...|..||.||:||:..|:..|:...:||.||.:...|.|...|:..
 Worm   380 HYNNPELHKGVIDSSGFQFFVTGQLRKYDAGIMELGLIYSDANSVPPNQKAWAMNGYCPSQCTKN 444

  Fly   411 MFPKDGIKIISGTLHSHQAGRTISLRHVRSGKELNPIIVDENYDYRHQKVHQLANETVVLPGDYL 475
            : |::||.|.:..||:|..||.:.....|||..:..:..||:|....|.:.||.....|:|||.|
 Worm   445 L-PEEGINIFASQLHAHLTGRKLFTSQYRSGVRIGDVNRDEHYSPHWQHLQQLRPVVKVMPGDTL 508

  Fly   476 ITDCSYETKYRKRPTFGGYSTKEEMCLTFITYYPKIEMSGC---YSMTPVREFF--------EMF 529
            :|.|.|:|:.|.:.|||||...:|||:.:|.|||..::..|   .|.:.:|.:|        :..
 Worm   509 VTTCVYDTRKRSKVTFGGYRIVDEMCVNYIYYYPASDVEVCKSAISNSTLRAYFSERHGMDGKRM 573

  Fly   530 RVYQFYSLNMTDVENMFLYNSDYTDYSKQAKNATNKPNSGKTSKEDVIYQESLLNKLVIS-DPAE 593
            ::...|| |:.|..|         ...::..|..|..|..             :|.|..: :|.|
 Worm   574 QISDMYS-NVKDWGN---------GVDEEFYNVLNVGNMN-------------MNCLKSNGEPFE 615

  Fly   594 FHDRTFLSHLNQLPWHDPLFTKRVEQAFITGTHMTFCRVSKDSLSIPS 641
            |..:.     ::..|.:     .....|::|:.:|    ::|....|:
 Worm   616 FESKD-----SRQSWEN-----MARPTFVSGSFIT----TRDRFQCPA 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5235	NP_648833.1	DOMON	56..173	CDD:460893	28/129 (22%)
		Cu2_monooxygen	215..355	CDD:460053	41/144 (28%)
		Cu2_monoox_C	373..529	CDD:461021	57/166 (34%)
tbh-1	NP_001257264.1	DoH	102..233	CDD:214768	30/147 (20%)
		Cu2_monooxygen	270..388	CDD:460053	42/147 (29%)
		Cu2_monoox_C	407..562	CDD:461021	56/155 (36%)