DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5235 and DBH

DIOPT Version :9

Sequence 1:	NP_001261921.1	Gene:	CG5235 / 39758	FlyBaseID:	FBgn0036565	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_000778.3	Gene:	DBH / 1621	HGNCID:	2689	Length:	617	Species:	Homo sapiens

Alignment Length:	513	Identity:	153/513 - (29%)
Similarity:	245/513 - (47%)	Gaps:	58/513 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MDSLGLYWLKWWINANENSIYFEVTVHTRGFAGL--GFSKDGRLARADMVLMWVDDATGH--PNV 110
            :|..|...|.|.::..:.:|:|::.|. |..||:  |.|..|.|..||:|::|.|..|.:  ...
Human    53 LDPEGSLELSWNVSYTQEAIHFQLLVR-RLKAGVLFGMSDRGELENADLVVLWTDGDTAYFADAW 116

  Fly   111 LDCHGALHPSSGPPLQDDTQNYDVLDGKQNGTHTILKFKRKIETCDPFDIPLSADTFKVLWSIGE 175
            .|..|.:|       .|..|:|.:|..::......|.|||...||||.|..:...|..:::.|.|
Human   117 SDQKGQIH-------LDPQQDYQLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYGILE 174

  Fly   176 N-----DPIHGNLDWQGQSRGVKALQLFSPMFTKNSHSIEGIQKWDITVNNVTIDRSMDTLYWCK 235
            .     :.|:|:    |...|::.:||..|...:.....:.. ..::...|:.|. |.:|.|||.
Human   175 EPFRSLEAINGS----GLQMGLQRVQLLKPNIPEPELPSDAC-TMEVQAPNIQIP-SQETTYWCY 233

  Fly   236 IVRLPELTGKQHIIGYEPLLSGKYERNVVHHMTLFECQSKI-----YSGSDPSSWDLWVRSAGTV 295
            |..||:...:.|||.|||::: |....:||||.:|:|..::     :||.
Human   234 IKELPKGFSRHHIIKYEPIVT-KGNEALVHHMEVFQCAPEMDSVPHFSGP--------------- 282

  Fly   296 CNSNLLTPRDWDSCSTPVAVWSLGSDGQFLPPHAGIPMGGASGVSYYMLEIHYDNP---DGKESV 357
            |:|. :.|...:.|...:|.|:||:...:.|..||:..||.....|..||:||.||   :|:.
Human   283 CDSK-MKPDRLNYCRHVLAAWALGAKAFYYPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRN-- 344

  Fly   358 DHSGFRIHYTPNLRTYDSGILISGVSISETQLIPPGQKKYRSVGICGPSCSSVMFPKDGIKIISG 422
            |.||.|::||..||.:::||:..|:..:....|||.:..:...|.|...|:.:..|..||.|.:.
Human   345 DSSGIRLYYTAKLRRFNAGIMELGLVYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFAS 409

  Fly   423 TLHSHQAGRTISLRHVRSGKELNPIIVDENYDYRHQKVHQLANETVVLPGDYLITDCSYETKYRK 487
            .||:|..||.:....||.|:|...:..|.:|....|::..|.....|.|||.|||.|:|.|:.|:
Human   410 QLHTHLTGRKVVTVLVRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRE 474

  Fly   488 RPTFGGYSTKEEMCLTFITYYPKIEMSGCYSMTP---VREFFEMFRVYQFYSLNMTDV 542
            ..|.||:...||||:.::.|||:.::..|.|...   ::::|.:...:     |..||
Human   475 LATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDAGFLQKYFHLINRF-----NNEDV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5235	NP_001261921.1	DOMON	54..174	CDD:281361	36/123 (29%)
		Cu2_monooxygen	214..354	CDD:279429	45/147 (31%)
		Cu2_monoox_C	374..529	CDD:281675	50/157 (32%)
DBH	NP_000778.3	DOMON	57..172	CDD:281361	36/122 (30%)
		Cu2_monooxygen	213..337	CDD:279429	43/141 (30%)
		Cu2_monoox_C	362..516	CDD:281675	49/153 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3568
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4822
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1472750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770