DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Diap1 and XIAP

DIOPT Version :9

Sequence 1:	NP_001261916.1	Gene:	Diap1 / 39753	FlyBaseID:	FBgn0260635	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001158.2	Gene:	XIAP / 331	HGNCID:	592	Length:	497	Species:	Homo sapiens

Alignment Length:	495	Identity:	131/495 - (26%)
Similarity:	184/495 - (37%)	Gaps:	182/495 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LPSYGPIAFDQVDNNTNATQLFKN----NINKT---RMNDLNREETRLKTFTDWPLDW--LDKRQ 63
            |.|....|.|: .:.|:|..|.:.    :|:.|   |...:..||.|||:|.:|| |:  |..|:
Human   121 LGSRDHFALDR-PSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWP-DYAHLTPRE 183

  Fly    64 LAQTGMYFTHAGDKVKCFFCGVEIGCWEQEDQPVPEHQRWSPNCPLLRRRTTN-NVPINAEALDR 127
            ||..|:|:|..||:|:||.||.::..||..|:...||:|..|||..:..|..| ....:|.:.||
Human   184 LASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDR 248

  Fly   128 ILPPISYDICGANDSTLEMREHAYAEGVIPMSQLIQSIGMNAVNAAGSVTGTAAPQPRVTVATHA 192
            ..|                                     |:.|
Human   249 NFP-------------------------------------NSTN--------------------- 255

  Fly   193 STATQATGDVQPETCRPSAASGNYFPQYPEYAIETARLRTFEAWPRNLKQKPHQLAEAGFFYTGV 257
                                    .|:.|..|...||:.||..|..::.::  |||.|||:..|.
Human   256 ------------------------LPRNPSMADYEARIFTFGTWIYSVNKE--QLARAGFYALGE 294

  Fly   258 GDRVRCFSCGGGLMDWNDNDEPWEQHALWLSQCRFVKLMKGQLYI-------------------- 302
            ||:|:||.|||||.||..:::||||||.|...|:::...|||.||
Human   295 GDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKT 359

  Fly   303 --------DTVAAKPVLAEE-------------KEESSSIGG-------VAVA------STQASE 333
                    ||:...|::.|.             .||...|.|       |.||      .....:
Human   360 PSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQD 424

  Fly   334 EEQQTSLSSEEAVSGDVAPSVAPTAATRIFNKIVEATAVATPSTNSSGSTSIPEEKLCKICYGAE 398
            |..||||..|.:....:                                ..:.||||||||....
Human   425 ESSQTSLQKEISTEEQL--------------------------------RRLQEEKLCKICMDRN 457

  Fly   399 YNTAFLPCGHVVACAKCASSVTKCPLCRKPFTDVMRVYFS 438
            ....|:||||:|.|.:||.:|.|||:|....|...:::.|
Human   458 IAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Diap1	NP_001261916.1	BIR	44..112	CDD:197595	32/69 (46%)
		BIR	226..295	CDD:197595	32/68 (47%)
		zf-C3HC4_3	387..432	CDD:290631	23/44 (52%)
XIAP	NP_001158.2	BIR 1	26..93
		BIR	28..95	CDD:237989
		Interaction with caspase-7	141..149		0/7 (0%)
		BIR	162..232	CDD:197595	32/70 (46%)
		BIR 2	163..230		32/67 (48%)
		BIR	265..331	CDD:197595	32/67 (48%)
		BIR 3	265..330		32/66 (48%)
		UBA_BIRC4_8	370..419	CDD:270578	9/48 (19%)
		RING-HC_BIRC4_8	436..497	CDD:319628	23/92 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340284at2759
OrthoFinder	1	1.000	-	-		FOG0000512
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100552
Panther	1	1.100	-	-	O	PTHR10044
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.780