Protein Alignment Diap1 and BIRC3

DIOPT Version :9

• Sequence 1: NP_001261916.1
• Gene: Diap1 / 39753
• FlyBaseID: FBgn0260635
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_001156.1
• Gene: BIRC3 / 330
• HGNCID: 591
• Length: 604
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 133/564 - (23%)
• Similarity: 181/564 - (32%)
• Gaps: 253/564 - (44%)

  Fly    22 NTNATQLFKNNINKTRMNDLNREETRLKTFTDWPLDWLDKRQLAQTGMYFTHAGDKVKCFFCGVE 86
            |:.|.|.|...:..:....:|.|..||.||..|||.:|....||:.|.|:...||:|.||.||.:
Human   147 NSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGK 211

  Fly    87 IGCWEQEDQPVPEHQRWSPNCPLLRRRTTNNVPINAEALDRILPPISYDICGANDSTLEMREHAY 151
            :..||.:|..:.||.|..|.||.:.              :::.....|.:     |.|.|:.||
Human   212 LSNWEPKDNAMSEHLRHFPKCPFIE--------------NQLQDTSRYTV-----SNLSMQTHA- 256

  Fly   152 AEGVIPMSQLIQSIGMNAVNAAGSVTGTAAPQPRVTVATHASTATQATGDVQPETCRPSAASGNY 216
                                                                             
Human   257 ----------------------------------------------------------------- 256

  Fly   217 FPQYPEYAIETARLRTFEAWPRNLKQKPHQLAEAGFFYTGVGDRVRCFSCGGGLMDWNDNDEPWE 281
                       ||.:||..||.::...|.|||.|||:|.|..|.|:||.|.|||..|...|:||.
Human   257 -----------ARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWV 310

  Fly   282 QHALWLSQCRFVKLMKGQLYIDTV-AAKPVLAE-----------EKEESSSIG------------ 322
            |||.|..:|.::..:|||.:|..| |:.|.|.|           |..|||.|.
Human   311 QHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAI 375

  Fly   323 -------GVAV------------------------------------ASTQASEEEQ-------- 336
                   ..||                                    |..:..|||:
Human   376 MMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKE 440

  Fly   337 ----------------------------------------------QTSLSSEE-----AVSGDV 350
                                                          ||||.:.|     .|.|::
Human   441 SNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNI 505

  Fly   351 APSVAPTAATRIFNKIVEATAVA------------TPSTNSSGSTSIP---------EEKLCKIC 394
                   |||...|.:.||.||.            .|:.:.|   .:|         ||:.||:|
Human   506 -------AATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVS---DLPVEEQLRRLQEERTCKVC 560

  Fly   395 YGAEYNTAFLPCGHVVACAKCASSVTKCPLCRKPFTDVMRVYFS 438
            ...|.:..|:||||:|.|..||.|:.|||:||......:|.:.|
Human   561 MDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Diap1	NP_001261916.1	BIR	44..112	CDD:197595	29/67 (43%)
		BIR	226..295	CDD:197595	32/68 (47%)
		zf-C3HC4_3	387..432	CDD:290631	21/44 (48%)
BIRC3	NP_001156.1	BIR	28..98	CDD:197595
		BIR 1	29..96
		BIR	168..237	CDD:197595	29/82 (35%)
		BIR 2	169..235		29/65 (45%)
		BIR	254..322	CDD:197595	34/144 (24%)
		BIR 3	255..322		34/143 (24%)
		UBA_like_SF	377..>411	CDD:304366	2/33 (6%)
		CARD_BIRC2_BIRC3	441..530	CDD:260038	15/95 (16%)
		zf-C3HC4_3	553..598	CDD:290631	21/44 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8356
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340284at2759
OrthoFinder	1	1.000	-	-		FOG0000512
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100552
Panther	1	1.100	-	-	O	PTHR10044
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.780