Protein Alignment Diap1 and MYLIP

DIOPT Version :10

• Sequence 1: NP_524101.2
• Gene: Diap1 / 39753
• FlyBaseID: FBgn0260635
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_037394.2
• Gene: MYLIP / 29116
• HGNCID: 21155
• Length: 445
• Species: Homo sapiens
• Alignment Length: 263
• Identity: 55/263 - (20%)
• Similarity: 91/263 - (34%)
• Gaps: 65/263 - (24%)

  Fly   184 PRVTVATHAS-----TATQATGD---VQPETCRPSAASGNYFPQYPEYAIETARLRTFEAWPRNL 240
            |.|.:||.:.     |.|:.:|:   :..:.....||||.|
Human   225 PVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLY------------------------ 265

  Fly   241 KQKPHQLAEAGFFYTGVGDRVRCFSCGGGLMDWNDNDEPWEQHALWLSQCRFVKLMKGQLYIDTV 305
                ..:.|...||       ||.:....:|.....|......:|:|::    .:..|:.|:..:
Human   266 ----RAITETHAFY-------RCDTVTSAVMMQYSRDLKGHLASLFLNE----NINLGKKYVFDI 315

  Fly   306 --AAKPVLAEEKEESSSIGGVAVASTQASEEEQQTSLSSEEAVSGDVAPSVAPTAATRIFNKIVE 368
              .:|.|....:....:.|.|.:.|............|||.:::......:: ...||:..:.:.
Human   316 KRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLS-CQQTRVLQEKLR 379

  Fly   369 ATAVATPSTNSSGSTSIPEEKLCKICYGAEYNTAFLPCGHVVACAKCASSVTKCPLCRKPFTDVM 433
                           .:.|..||.:|...|.|:.|.||||.|.|..||:.:..||:||.....|.
Human   380 ---------------KLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQ 429

  Fly   434 RVY 436
            .||
Human   430 HVY 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Diap1	NP_524101.2	BIR	44..112	CDD:197595
		BIR	226..295	CDD:197595	9/68 (13%)
		RING-HC_IAPs	388..427	CDD:438173	17/38 (45%)
MYLIP	NP_037394.2	FERM_F1_MYLIP	1..81	CDD:340624
		B41	5..190	CDD:214604
		FERM_C_MYLIP_IDOL	185..295	CDD:270016	19/104 (18%)
		RING-HC_MYLIP	383..434	CDD:438186	22/50 (44%)
		Critical for homodimerization	431..433		2/2 (100%)