DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Diap1 and Naip2

DIOPT Version :9

Sequence 1:	NP_001261916.1	Gene:	Diap1 / 39753	FlyBaseID:	FBgn0260635	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001119654.1	Gene:	Naip2 / 17948	MGIID:	1298226	Length:	1447	Species:	Mus musculus

Alignment Length:	323	Identity:	88/323 - (27%)
Similarity:	126/323 - (39%)	Gaps:	83/323 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 NKTRMNDLNREETRLKTFTDWPL--DWLDKRQLAQTGMYFTHAGDKVKCFFCGVEIGCWEQEDQP 96
            :|.|.::   ||.||::|.|||.  .....|.|:..|..||...|.|:||.||..:|.||:.|.|
Mouse   152 DKARYHE---EEARLESFEDWPFYAHGTSPRVLSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDP 213

  Fly    97 VPEHQRWSPNCPLLRRRTTNNVPINAEALDRILPPISYDICGANDSTLEMREHAYA-EGVIPMSQ 160
            ..||.:|.|.|..|:                           :..|..|:.::..: ||.:.::
Mouse   214 WKEHAKWFPKCEFLQ---------------------------SKKSPEEITQYVQSYEGFLHVT- 250

  Fly   161 LIQSIGMNAVNAAGSVTGTAAPQPRVTVATHASTATQATGDVQPETCRPSAASGNYFPQYPEYAI 225
                 |.:.||     :......|.|:.                 .|..|.           :|.
Mouse   251 -----GEHFVN-----SWVRRELPMVSA-----------------YCNDSV-----------FAN 277

  Fly   226 ETARLRTFEAWPRNLKQKPHQLAEAGFFYTGVGDRVRCFSCGGGLMDWNDNDEPWEQHALWLSQC 290
            |..|:.||:.||.........|.:||.||||..|.|:||||||.:..|.:.|.|.|.|..:...|
Mouse   278 EELRMDTFKDWPHESPGAVEALVKAGLFYTGKRDIVQCFSCGGCMEKWAEGDNPIEDHTKFFPNC 342

  Fly   291 RFVKLMKGQLYI----DTVAAKPVLAEEKEESSSIGGVAVAST-------QASEEEQQTSLSS 342
            .|::.:|....:    .:..|.|...|...||:.....||.||       :|.|.|..:||.|
Mouse   343 VFLQTLKSSAEVIPALQSHCALPEAMETTSESNHDDAAAVHSTVVDVSPSEAQELEPASSLVS 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Diap1	NP_001261916.1	BIR	44..112	CDD:197595	30/69 (43%)
		BIR	226..295	CDD:197595	28/68 (41%)
		zf-C3HC4_3	387..432	CDD:290631
Naip2	NP_001119654.1	BIR 1	60..127
		BIR	61..129	CDD:237989
		BIR	159..229	CDD:197595	30/96 (31%)
		BIR 2	159..227		29/67 (43%)
		BIR	277..346	CDD:197595	28/68 (41%)
		BIR 3	278..345		27/66 (41%)
		AAA	507..644	CDD:214640
		NACHT	508..662	CDD:283404
		LRR_RI	1106..1373	CDD:238064
		leucine-rich repeat	1201..1226	CDD:275381
		leucine-rich repeat	1227..1251	CDD:275381
		leucine-rich repeat	1252..1280	CDD:275381
		leucine-rich repeat	1281..1305	CDD:275381
		leucine-rich repeat	1306..1337	CDD:275381
		leucine-rich repeat	1338..1366	CDD:275381
		leucine-rich repeat	1367..1399	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770