DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Diap1 and Birc6

DIOPT Version :9

Sequence 1:	NP_001261916.1	Gene:	Diap1 / 39753	FlyBaseID:	FBgn0260635	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	XP_006523581.1	Gene:	Birc6 / 12211	MGIID:	1276108	Length:	4953	Species:	Mus musculus

Alignment Length:	481	Identity:	104/481 - (21%)
Similarity:	173/481 - (35%)	Gaps:	129/481 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 EETRLKTFTDWP---LDWLDKRQLAQTGMYFTHAG---DKVKCFFCGVEIGCWEQEDQPVPEHQR 102
            |..|.:|||.||   ..|.....:||.|.|...|.   |:..||.|.|.:.|||..|:|..||:|
Mouse   346 EANRRETFTSWPHVGYRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHER 410

  Fly   103 WSPNCPLLRRRTTNNVPI------------NAEALDRILPPISYDICGANDSTLEMREHAYAEGV 155
            .|||||.::...|.|||:            :|:..|||       .|..:.|..:....|...|.
Mouse   411 HSPNCPFVKGEHTQNVPLSVTLATSPAQLPSADGADRI-------ACFGSGSCPQFLAAATKRGK 468

  Fly   156 I---PMSQLIQ---SIGMNAVNAA---------GSVTGTAAPQPRVTVATHASTAT---QATGDV 202
            |   .:|:|::   ...:||.:.|         ...:|..:.:|.:.....:|:.:   :..||.
Mouse   469 ICIWDVSKLMKVHLKFEINAYDPAIVQQLILSGDPSSGVDSRRPTLAWLEDSSSCSDIPKLEGDS 533

  Fly   203 --------QPETCRPSAASGNYF-PQYPEYAIETARLRTFEAWPRNLKQKPHQLAEAGFFYTGVG 258
                    ..|..|..:.:|:.. .:..|.:::...|        ::.|:|.:| :.......:.
Mouse   534 DDLLEDSDSEEHSRSDSVTGHTSQKEAMEVSLDITAL--------SILQQPEKL-QWEIVANVLE 589

  Fly   259 DRVRCF-SCGGGLMDWNDNDEP-----WEQHALWLSQCRFVKLMKGQLY-IDTVAAKPVLAEEKE 316
            |.|:.. ..|......|...|.     .|||.:     .|..|:.|.|. ..:.|..|:   ...
Mouse   590 DTVKDLEELGANPSLTNSKSEKTKEKHQEQHNI-----PFPCLLAGGLLTYKSPATSPI---SSN 646

  Fly   317 ESSSIGGVAVASTQASEEEQQTSLSSEEAVSGDV-APSVAPTAATRIFNKIVEA----------- 369
            ...|:.|  ::.||.....:|.|..:|...:.:: :|.|..|....:...|.|:
Mouse   647 SHRSLDG--LSRTQGESISEQGSTDNESCTNSELNSPLVRRTLPVLLLYSIKESDEKAGKIFSQM 709

  Fly   370 TAVATPSTNSSGSTSIP---------EEKLC----KICY---------------GAEYNTAFLPC 406
            ..:.:.|.:..|.| :|         :|:|.    .:.|               ..::|:.|...
Mouse   710 NNIMSKSLHDDGFT-VPQIIEMELDNQEQLLLQDPPVTYIQQFADAAASLTSPDSEKWNSVFPKP 773

  Fly   407 GHVVACAK----------CASSVTKC 422
            |.:|.|.:          |..|:|.|
Mouse   774 GALVQCLRLPKFAEEETLCIDSITPC 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Diap1	NP_001261916.1	BIR	44..112	CDD:197595	31/73 (42%)
		BIR	226..295	CDD:197595	13/74 (18%)
		zf-C3HC4_3	387..432	CDD:290631	12/65 (18%)
Birc6	XP_006523581.1	BIR	347..420	CDD:237989	30/72 (42%)
		BIRC6	3558..3712	CDD:372067
		UBCc	4693..4831	CDD:238117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810