DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Notum and notum2

DIOPT Version :9

Sequence 1:	NP_730096.2	Gene:	Notum / 39751	FlyBaseID:	FBgn0044028	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001340801.1	Gene:	notum2 / 566040	ZFINID:	ZDB-GENE-120215-77	Length:	495	Species:	Danio rerio

Alignment Length:	606	Identity:	179/606 - (29%)
Similarity:	275/606 - (45%)	Gaps:	212/606 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 SGSGDHSR---------------------SLKRANLANTSITCNDGSHAGFYLRKHPSSKKWIVL 122
            :|:||.|:                     .:|...|.||::|||||:.|||||::...||:|::.
Zfish    56 AGAGDSSKETNPGGRGSSQQSASVNKPADDMKLHFLKNTAVTCNDGTAAGFYLKEFKGSKRWLIF 120

  Fly   123 LEGGWHCFDVRSCRSRWMRLRHLMTSSQWPETRDVGGILSPHPEENPYWHNANHVLIPYCSSDSW 187
            |||||.|:...:|.||:..:..||.|:.||:||...|:||...:|||:|:|||.|.:||||||.|
Zfish   121 LEGGWCCYSKETCDSRYKTIPRLMGSTDWPQTRRGSGLLSAQVDENPHWYNANIVFVPYCSSDVW 185

  Fly   188 SGTR--TEPDTSDRENSWRFMGALILRQVIAELIPVGLGRVPGGELMLVGSSAGGMGVMLNLDRI 250
            ||.:  ::| ...:|..:.|||:.|:|:||.:|:|.||.:..  .:||.|:||||.||:||:|::
Zfish   186 SGNKAASKP-KQGKETEYAFMGSQIIREVIKDLVPKGLKQAK--VVMLAGTSAGGTGVLLNIDKV 247

  Fly   251 RDFLVNEKKLQITVRGVSDSGWFLD----REPYTP--AAVASNEAVRQGWKLWQGLLPEECTKSY 309
            .. |:.::..:..|||:.||||||:    :.|..|  |:....:|:::|.:||.|::||:|.:.|
Zfish   248 SS-LLEQQGAEAQVRGLVDSGWFLESKQQKVPDCPDSASCTPADAIKKGLRLWNGVVPEKCKQQY 311

  Fly   310 PT-EPWRCYYGYRLYPTLKTPLFVFQWLFDEAQMRVDNV---GAPVTPQQWNYIHEMGGALRSSL 370
            .. |.|.|::|::||..:..||||.||||||.|:||:|:   ...::.|||.|:..:|..|::||
Zfish   312 KRGEDWHCFFGHKLYSYISAPLFVVQWLFDEEQLRVENIYMGSQSLSEQQWTYMQNLGKELKNSL 376

  Fly   371 DNVSAVFAPSCIGHGVLFKRDWVNIKIDDISLPSALRCWEHSTRSRRHDKLKRSTEPSTAVSHPE 435
            .:|:|||||||:.|.::.|.:|.:.:|...||..||:||:.|
Zfish   377 KDVTAVFAPSCLSHTLITKSNWTDFQIKGTSLSRALQCWDRS----------------------- 418

  Fly   436 HANNQRHQRHRQRLQRQKHNNVAQSGGQQRKHNHLSKEEREERKRLRQEQRQRRKQRRRQQQQKK 500

Zfish   419 ----------------------------------------------------------------- 418

  Fly   501 ANGGQEHRNKKDNSPKSSNGNDQRKQRRRQQLTAEERQEQRKRRRKAQQQQMKMQREQPAAGVFL 565
                                                                           |.
Zfish   419 ---------------------------------------------------------------FQ 420

  Fly   566 EASAPQKTRSSNNASAGTKSKKRHRVPRVPEKCGLRLLERCSWPQCNHSCPTLTNPMTGEEMRFL 630
            ||:     ::|..|..|               |...|::.|.|||||.:||.|.:..|.:||..|
Zfish   421 EAN-----KNSKTALKG---------------CPFHLIDNCQWPQCNPTCPALIDQATQQEMTLL 465

  Fly   631 ELLTAFGLDIEAVAAALGVDM 651
            ::|.:.|||::    .||:|:
Zfish   466 QVLASMGLDLQ----KLGLDV 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Notum	NP_730096.2	PAE	99..409	CDD:281299	140/321 (44%)
notum2	NP_001340801.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..80		4/23 (17%)
notum2	NP_001340801.1	PAE	79..418	CDD:308742	146/342 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591949
Domainoid	1	1.000	332	1.000	Domainoid score	I1118
eggNOG	1	0.900	-	-		E1_KOG4287
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	393	1.000	Inparanoid score	I1930
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D203180at33208
OrthoFinder	1	1.000	-	-		FOG0004840
OrthoInspector	1	1.000	-	-		otm24783
orthoMCL	1	0.900	-	-		OOG6_102699
Panther	1	1.100	-	-	O	PTHR21562
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3973
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760