DRSC/TRiP Functional Genomics Resources

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Protein Alignment Notum and NOTUM

DIOPT Version :9

Sequence 1:NP_730096.2 Gene:Notum / 39751 FlyBaseID:FBgn0044028 Length:671 Species:Drosophila melanogaster
Sequence 2:NP_848588.3 Gene:NOTUM / 147111 HGNCID:27106 Length:496 Species:Homo sapiens


Alignment Length:631 Identity:196/631 - (31%)
Similarity:279/631 - (44%) Gaps:206/631 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 EKDPLRDTSMNMIQRNYMVMHSASGSGDHSRSLKRAN-------LANTSITCNDGSHAGFYLRKH 113
            |..||..|::.....::|....:.....:..|.::.|       |.|||:||||||.||:||::.
Human    50 ESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKES 114

  Fly   114 PSSKKWIVLLEGGWHCFDVRSCRSRWMRLRHLMTSSQWPETRDVGGILSPHPEENPYWHNANHVL 178
            ..|::|::.|||||:||:..:|.||:..:|.||:|..||.||...||||..|||||||.|||.|.
Human   115 RGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVF 179

  Fly   179 IPYCSSDSWSGTRTEPDTSDRENSWRFMGALILRQVIAELIPVGLGRVPGGE-LMLVGSSAGGMG 242
            |||||||.|||..::.:    :|.:.||||||:::|:.||:..||.   |.: |:|.||||||.|
Human   180 IPYCSSDVWSGASSKSE----KNEYAFMGALIIQEVVRELLGRGLS---GAKVLLLAGSSAGGTG 237

  Fly   243 VMLNLDRIRDFLVNEKKLQITVRGVSDSGWFLDREPY------TPAAVASNEAVRQGWKLWQGLL 301
            |:||:||:.:.|.......|.|||::|||||||.:.|      .....|..||:|:|.:.|.|::
Human   238 VLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNGVV 302

  Fly   302 PEECTKSYPT-EPWRCYYGYRLYPTLKTPLFVFQWLFDEAQMRVDNV---GAPVTPQQWNYIHEM 362
            ||.|.:.:.. |.|.|::||::||||:.|:||.||||||||:.||||   |.||......||..:
Human   303 PERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGLRLYIQNL 367

  Fly   363 GGALRSSLDNVSAVFAPSCIGHGVLFKRDWVNIKIDDISLPSALRCWEHSTRSRRHDKLKRSTEP 427
            |..||.:|.:|.|.|||:|:.|.::.:..|.::::...|||.||.||:.|.    ||.       
Human   368 GRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSL----HDS------- 421

  Fly   428 STAVSHPEHANNQRHQRHRQRLQRQKHNNVAQSGGQQRKHNHLSKEEREERKRLRQEQRQRRKQR 492
                                                                             
Human   422 ----------------------------------------------------------------- 421

  Fly   493 RRQQQQKKANGGQEHRNKKDNSPKSSNGNDQRKQRRRQQLTAEERQEQRKRRRKAQQQQMKMQRE 557
                                                                             
Human   422 ----------------------------------------------------------------- 421

  Fly   558 QPAAGVFLEASAPQKTRSSNNASAGTKSKKRHRVPRVPEK-CGLRLLERCSWPQCNHSCPTLTNP 621
                                           |:..:.|.| |.:.|::.|.||.||.||||:.:.
Human   422 -------------------------------HKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQ 455

  Fly   622 MTGEEMRFLELLTAFGLDIEAVAAALGVDMHTLNNMERTELVNMLT 667
            .||:||...:.|...|.|::.||...|        :|.:||:.||:
Human   456 FTGQEMNVAQFLMHMGFDMQTVAQPQG--------LEPSELLGMLS 493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NotumNP_730096.2 PAE 99..409 CDD:281299 151/320 (47%)
NOTUMNP_848588.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 21..46
PAE 82..417 CDD:281299 158/341 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 321 1.000 Domainoid score I1228
eggNOG 1 0.900 - - E1_KOG4287
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H45335
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D203180at33208
OrthoFinder 1 1.000 - - FOG0004840
OrthoInspector 1 1.000 - - oto89651
orthoMCL 1 0.900 - - OOG6_102699
Panther 1 1.100 - - LDO PTHR21562
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9637
SonicParanoid 1 1.000 - - X3973
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.810

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