DRSC/TRiP Functional Genomics Resources

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Protein Alignment mib1 and SQSTM1

DIOPT Version :10

Sequence 1:NP_648826.2 Gene:mib1 / 39750 FlyBaseID:FBgn0263601 Length:1226 Species:Drosophila melanogaster
Sequence 2:NP_003891.1 Gene:SQSTM1 / 8878 HGNCID:11280 Length:440 Species:Homo sapiens


Alignment Length:530 Identity:111/530 - (20%)
Similarity:173/530 - (32%) Gaps:190/530 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 GGNSAAALVRRFSM-----EGVGARVIRGPD------------WKWNKQDGGEGHV----GTVRN 135
            |...||..:||||.     ....|....||.            :...:..|.:.|.    |.:..
Human    12 GKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVA 76

  Fly   136 FESAEEVVVVWDNGTAANY--------------RCAGAYDLRILDSAPTGVKHEGTMCDTCRQQP 186
            |.|.||:.:      |.:|              .|...:.......||..:.|...:||.| ..|
Human    77 FSSDEELTM------AMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGC-NGP 134

  Fly   187 IFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRITTPGGERTMLEPRRKSKKVLARGIFPGARV 251
            :.|.|:||:.|.:|||||:| .|...|..|......:|.|.             |:.| |..:|.
Human   135 VVGTRYKCSVCPDYDLCSVC-EGKGLHRGHTKLAFPSPFGH-------------LSEG-FSHSRW 184

  Fly   252 VRGV-----DWQ-WEDQDGGVGRRGKVNEIQDWSSASPRSAAYVIWDNGSKNLYRVGFEGMADLK 310
            :|.|     .|. ||     :|..|      :||...||:                         
Human   185 LRKVKHGHFGWPGWE-----MGPPG------NWSPRPPRA------------------------- 213

  Fly   311 VVNDAKGSNVYRDHLPLLGENGPG------KGPHGFQIGDKVTVDLDLEIVQSLQHGHGGWTDGM 369
                              ||..||      .||         :.|..:..::::       .:.:
Human   214 ------------------GEARPGPTAESASGP---------SEDPSVNFLKNV-------GESV 244

  Fly   370 FECLSNAGMVVGIDEDHDIVVAYNSGNRWTFNPAVLTKVSSPTTAPPEFQVGDIVKICSDVESIK 434
            ...||..|:.|.||.:|       .|.|     :.||.||..:::..|.........|||...  
Human   245 AAALSPLGIEVDIDVEH-------GGKR-----SRLTPVSPESSSTEEKSSSQPSSCCSDPSK-- 295

  Fly   435 ILQRGHGEWA------DAMQLTLGKIGR-VQQVYHDNDLKVEVGNTSWTYNPLAVCKVASSTA-- 490
              ..|:.|.|      ...::.|...|| .:|:..||   ...|:..||:  |:..:|..||.  
Human   296 --PGGNVEGATQSLAEQMRKIALESEGRPEEQMESDN---CSGGDDDWTH--LSSKEVDPSTGEL 353

  Fly   491 -------SDGSCAPVIPSSERLSAILKKLFEPNVSGDATEEFVKAAAN----GFA---------A 535
                   |:|. :.:.||.|..:.:.:....|::..:|....:::.:.    ||:         .
Human   354 QSLQMPESEGP-SSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLL 417

  Fly   536 RCEEYLAGAA 545
            :.:.|..|||
Human   418 QTKNYDIGAA 427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mib1NP_648826.2 MIB_HERC2 109..166 CDD:461991 13/86 (15%)
ZZ_Mind_bomb 177..221 CDD:239079 18/43 (42%)
MIB_HERC2 248..313 CDD:461991 12/70 (17%)
SH3_15 340..405 CDD:465720 10/64 (16%)
SH3_15 418..482 CDD:465720 16/70 (23%)
ANKYR 559..824 CDD:440430
ANK repeat 568..598 CDD:293786
ANK repeat 600..631 CDD:293786
ANK repeat 633..664 CDD:293786
ANK repeat 666..695 CDD:293786
ANK repeat 699..733 CDD:293786
ANK repeat 735..767 CDD:293786
ANK repeat 769..800 CDD:293786
ANK repeat 802..862 CDD:293786
RING-HC_MIB1_rpt1 968..1005 CDD:438384
RING-HC_MIB1_rpt2 1015..1052 CDD:438385
RING-HC_MIB1_rpt3 1181..1226 CDD:438387
SQSTM1NP_003891.1 Interaction with LCK. /evidence=ECO:0000269|PubMed:8650207 2..50 10/37 (27%)
PB1_p62 4..102 CDD:99723 19/95 (20%)
Interaction with PRKCZ and dimerization. /evidence=ECO:0000250|UniProtKB:O08623 43..107 10/69 (14%)
Interaction with PAWR. /evidence=ECO:0000269|PubMed:11755531 50..80 4/29 (14%)
Interaction with GABRR3. /evidence=ECO:0000250|UniProtKB:O08623 122..224 40/171 (23%)
ZZ_NBR1_like 126..168 CDD:239080 18/43 (42%)
LIM protein-binding (LB) 170..220 20/117 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 196..235 15/101 (15%)
TRAF6-binding 228..233 2/13 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..390 31/140 (22%)
Interaction with NTRK1. /evidence=ECO:0000250|UniProtKB:O08623 269..440 36/169 (21%)
MAP1LC3B-binding. /evidence=ECO:0000269|PubMed:17580304 321..342 7/25 (28%)
LIR 336..341 2/6 (33%)
Interaction with KEAP1. /evidence=ECO:0000269|PubMed:20452972 347..352 2/4 (50%)
UBA_5 379..440 CDD:318725 8/49 (16%)
Blue background indicates that the domain is not in the aligned region.

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