DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mib1 and AKR2

DIOPT Version :9

Sequence 1:NP_648826.2 Gene:mib1 / 39750 FlyBaseID:FBgn0263601 Length:1226 Species:Drosophila melanogaster
Sequence 2:NP_014677.1 Gene:AKR2 / 854199 SGDID:S000005560 Length:749 Species:Saccharomyces cerevisiae


Alignment Length:354 Identity:87/354 - (24%)
Similarity:130/354 - (36%) Gaps:81/354 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   523 EEFVKAAANGFAARCEEYLAGAAQPSTSSASPSSGPDVNVNGVFAGHTALQAASQNGHIEVIQVL 587
            :|.||..:||.|.     :...||.:.|.:.               :...|......:.|     
Yeast     9 DENVKKTSNGAAV-----VTDVAQHAVSDSD---------------NNKAQLLGDGSNTE----- 48

  Fly   588 LRHAVDVEIE-DKDGDRAVHHAAFGDEAAVIEILAKAGADLNARNKRRQTSLHIAVNKGHLNVVK 651
              :.||:.|| .||||..|          |.:::.....|:|.......:.||.|......:|.|
Yeast    49 --YVVDIFIEAAKDGDLKV----------VKDVVESGAVDINNDRIDELSGLHWACINNRFSVAK 101

  Fly   652 TLLTLGCHPSLQDSEGD-TPLHDAISKEHDEMLSLLLDFGADITLNNNNGFNALHHAALKGNPSA 715
            .||..|.:|:.....|. |.||.|....:..::.|||..|||.||.:..|.|.:|.:....|   
Yeast   102 FLLLRGANPNQAAGPGGATALHWAARYGNIYIVDLLLKHGADPTLKDEQGLNIMHFSVYSSN--- 163

  Fly   716 MKILL--------TKTNRPWIVEEKKDDGYTALHLAALNNHVEIAELLVHMGK--ANMDRQNVNL 770
              |||        ...|....::.|.::..|.|..||........|||:..|.  |..|.:..| 
Yeast   164 --ILLVVYVLYFVVNNNDNVDIDSKDNNNRTPLLWAAYQGDFLTVELLLKFGSTVAWTDNRGFN- 225

  Fly   771 QTALHLAVERQHVQIVKLLVQDGAD-----------LNIPDKDGDTPLHE-ALRHHTLSQLKQLQ 823
              |||.|:.....:::..|:..||:           .::.:..|...|.| ||:||...:|...:
Yeast   226 --ALHCALVGGDQRVICDLILSGANFYERNNQKQDCFDLAEGMGTKSLFEQALQHHGYDRLGNQK 288

  Fly   824 DVEGFGKLLMGLRNANNKKASASIACFLA 852
            |     ||.       .|.:.|....||:
Yeast   289 D-----KLF-------KKSSHAQFTIFLS 305

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mib1NP_648826.2 MIB_HERC2 109..165 CDD:284184
ZZ_Mind_bomb 177..221 CDD:239079
MIB_HERC2 248..312 CDD:284184
Ank_4 568..620 CDD:290365 12/52 (23%)
ANK repeat 568..598 CDD:293786 6/30 (20%)
ANK repeat 600..631 CDD:293786 7/30 (23%)
Ank_2 606..697 CDD:289560 25/91 (27%)
ANK 628..756 CDD:238125 38/136 (28%)
ANK repeat 633..664 CDD:293786 9/30 (30%)
ANK repeat 666..695 CDD:293786 11/29 (38%)
ANK repeat 699..733 CDD:293786 8/41 (20%)
Ank_2 704..800 CDD:289560 25/116 (22%)
ANK 734..872 CDD:238125 33/133 (25%)
ANK repeat 735..767 CDD:293786 10/33 (30%)
ANK repeat 769..800 CDD:293786 8/41 (20%)
Ank_2 774..862 CDD:289560 21/91 (23%)
ANK repeat 802..862 CDD:293786 15/52 (29%)
zf-C3HC4_3 968..1011 CDD:290631
zf-C3HC4_3 1013..1058 CDD:290631
zf-C3HC4_3 1179..1222 CDD:290631
AKR2NP_014677.1 ANKYR 1..195 CDD:223738 55/227 (24%)
ANK repeat 54..81 CDD:293786 10/36 (28%)
ANK repeat 83..115 CDD:293786 9/31 (29%)
ANK repeat 117..148 CDD:293786 13/30 (43%)
ANK repeat 189..220 CDD:293786 9/30 (30%)
Ank_4 190..243 CDD:372654 15/55 (27%)
ANK repeat 222..247 CDD:293786 6/27 (22%)
COG5273 340..711 CDD:227598
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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