DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mib1 and Mib2

DIOPT Version :9

Sequence 1:	NP_648826.2	Gene:	mib1 / 39750	FlyBaseID:	FBgn0263601	Length:	1226	Species:	Drosophila melanogaster
Sequence 2:	XP_006539310.1	Gene:	Mib2 / 76580	MGIID:	2679684	Length:	982	Species:	Mus musculus

Alignment Length:	1176	Identity:	388/1176 - (32%)
Similarity:	555/1176 - (47%)	Gaps:	262/1176 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 VGARVIRGPDWKWNKQDGGEGHVGTV----RNFESA---EEVVVVWDNGTAANYRCA--GAYDLR 163
            ||.||:||.||||.:||||||.||||    |:...:   ..|||.||.||..|||..  ||:||.
Mouse    11 VGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLL 75

  Fly   164 ILDSAPTGVKHEGTMCDTCRQQPIFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRITTPGGER 228
            :.|:|..|::|...:||.|::..:.|:||||..|.:||||:.||..:||.|.|.|.|..|.....
Mouse    76 LYDNAQIGIRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETSHSRP 140

  Fly   229 TMLEPRRKSKKVLARGIFPGARVVRGVDWQWEDQDGGVGRRGKVNEIQDWSSASPRSAAYVIWDN 293
            ..|.||:...::..||||.||:||||.||:|..||||.|:.|:|.:|:.|...:.||.|.|.|.:
Mouse   141 VTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASVTWAD 205

  Fly   294 GSKNLYRVGFEGMADLKVVNDAKGSNVYRDHLPLLGE--------NGPGKGPHGFQIGDKVTVDL 350
            |:.|:||||.:|..||:.|.:|.|...|::|||.||:        :..|:   .||.||||...|
Mouse   206 GTTNVYRVGHKGKVDLRCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQ---PFQRGDKVKCLL 267

  Fly   351 DLEIVQSLQHGHGGWTDGMFECLSNAGMVVGIDEDHDIVVAYNSGNRWTFNPAVLTKVSSPTTAP 415
            |.::::.:|.|||||...|.|.:...|.|..|.:..|:.|.:|...||||:|..|||.:|
Mouse   268 DTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQFNHETRWTFHPGALTKHNS----- 327

  Fly   416 PEFQVGDIVKICSDVESIKILQRGHGEWADAMQLTLGKIGRVQQVYHDNDLKVEVGNTSWTYNPL 480
              |.|||:|::..|::::|.||.|||||.|.|...||::|:|.:|:.|.:|:|.||...||::|
Mouse   328 --FWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVGGQRWTFSP- 389

  Fly   481 AVCKVA------------------SSTAS-------DGSCAPVIPSS---ERLSAILKKLFEPNV 517
             .|.||                  .|.||       .||..|.:.|:   ..||..|.||.....
Mouse   390 -SCLVAYRPEEDANLDVAERARENKSAASVSVAGGRQGSPWPALTSTLPPGSLSVALDKLRTQKS 453

  Fly   518 SGDATEEFVKAAANGFAARCEEYLAGAAQPSTSSASPSSGPDVNVNGVFAGHTALQAASQNGHIE 582
            ..:.....|..||.|..||..:.|....:              .|:....|.||||.|:..|.:|
Mouse   454 DPEHPGRLVVEAALGNVARALDLLRRHPE--------------QVDTKNQGRTALQVAAYLGQVE 504

  Fly   583 VIQVLLRHAVDVEIEDKDGDRAVHHAAFGDEAAVIEILAKAGADLNARNKRRQTSLHIAVNKGHL 647
            ::::||:....:::.|.:|:..:|:.|.|::.....:|..||..::|||..|.|:||:||.:|.|
Mouse   505 LVRLLLQARASMDLPDDEGNTVLHYTAMGNQPEATRVLLSAGCAVDARNGTRSTALHVAVQRGFL 569

  Fly   648 NVVKTLLTLGCHPSLQDSEGDTPLHDAIS--KEHDEMLSLLLDF-GADITLNNNNGFNALHHAAL 709
            .|||.|...||..:|.|:..|||||.|||  .....::.:|.:. |.|:|..|:.||..||||:|
Mouse   570 EVVKILCERGCDVNLPDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASL 634

  Fly   710 KGNPSAMKILLTKTNRPWIVEEKKDDGYTALHLAALNNHVEIAELLVHMGKANMDRQNVNLQTAL 774
            ||:..|::.:|.:..:  :|:.||:||:|||||||||||.|:|::|:..|:.:::.:|..||:.|
Mouse   635 KGHVLAVRKILARARQ--LVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPL 697

  Fly   775 HLAVERQHVQIVKLLVQDGADLNIPDKDGDTPLHEALRHHTLSQLKQLQDVEGF--GKLLM---- 833
            ||||::.|:.:|.|||..|..:|..|::|||.||.||:.|.|  |..:.|..|.  |.|.:
Mouse   698 HLAVQQAHLGLVPLLVDAGCSVNTEDEEGDTALHVALQRHQL--LPLVADRAGGDPGPLQLLSRL 760

  Fly   834 ---GLRNANNKKASASIACFLAANGADLTLKNRKQQTPLDLCPDPNLCKTLVKCYNERKTDDSEL 895
               ||.........|::|||||..|||::..|.:.::||||..:..:.|.|..|
Mouse   761 QASGLPGCTELTVGAAVACFLALEGADVSYANHRGRSPLDLATEGRVLKALQGC----------- 814

  Fly   896 PGNVAGTSSSARARAASGSLNQSSSVNMPLSSLAASSTFPAASSSSIFALNGIANEMSQSLHEDP 960
                   :...|.|.|.|...........||:
Mouse   815 -------AQRFRERQAGGGGGVPPGPRHVLST--------------------------------- 839

  Fly   961 PKSSASLDECLVCSDAKRDTVFKPCGHVSCCETCAPRVKKCLICRETVSSREKIDECLVCSDRRA 1025
            |.:..:|                   |||  .|..|...                ||||||:...
Mouse   840 PNTVTNL-------------------HVS--GTAGPEAA----------------ECLVCSELAL 867

  Fly  1026 AVFFRPCGHMVACEHCSALMKKCVLCRTQIDEILSFSLCCGGSGRPEKVSVAAGAMATVGLPLPD 1090
            .:.|.||.|...||.|:..||||:.|:..|.:.|          ||:...|.
Mouse   868 LILFSPCQHRTVCEECARRMKKCIRCQVVISKKL----------RPDGSEVV------------- 909

  Fly  1091 DRFMEAAAAAACANASGHSVAMNNTVVTPVAGSSNQLNSQNNLLAAAAASSNVSNLSAAGNAMVA 1155
                                   |.:..|  |...||
Mouse   910 -----------------------NAIQVP--GPPRQL---------------------------- 921

  Fly  1156 PSNVNNFQMDDVQKLKQQLQDIKEQTMCPVCFDRIKNMVFLCGHGTCQMCGDQIEGCPICRKTVE 1220
                       |::|:.:.:.::|:..||:|.|....:||.||||.|..||..:..|||||:.:.
Mouse   922 -----------VEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIR 975

  Fly  1221 KRILLF 1226
            .||.:|
Mouse   976 DRIQIF 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib1	NP_648826.2	MIB_HERC2	109..165	CDD:284184	34/64 (53%)
		ZZ_Mind_bomb	177..221	CDD:239079	20/43 (47%)
		MIB_HERC2	248..312	CDD:284184	32/63 (51%)
		Ank_4	568..620	CDD:290365	15/51 (29%)
		ANK repeat	568..598	CDD:293786	10/29 (34%)
		ANK repeat	600..631	CDD:293786	8/30 (27%)
		Ank_2	606..697	CDD:289560	37/93 (40%)
		ANK	628..756	CDD:238125	61/130 (47%)
		ANK repeat	633..664	CDD:293786	15/30 (50%)
		ANK repeat	666..695	CDD:293786	11/31 (35%)
		ANK repeat	699..733	CDD:293786	12/33 (36%)
		Ank_2	704..800	CDD:289560	44/95 (46%)
		ANK	734..872	CDD:238125	62/146 (42%)
		ANK repeat	735..767	CDD:293786	17/31 (55%)
		ANK repeat	769..800	CDD:293786	14/30 (47%)
		Ank_2	774..862	CDD:289560	38/96 (40%)
		ANK repeat	802..862	CDD:293786	25/68 (37%)
		zf-C3HC4_3	968..1011	CDD:290631	5/42 (12%)
		zf-C3HC4_3	1013..1058	CDD:290631	19/44 (43%)
		zf-C3HC4_3	1179..1222	CDD:290631	19/42 (45%)
Mib2	XP_006539310.1	MIB_HERC2	12..77	CDD:369043	34/64 (53%)
		ZZ_Mind_bomb	89..133	CDD:239079	20/43 (47%)
		MIB_HERC2	160..224	CDD:369043	32/63 (51%)
		SH3_15	257..322	CDD:375773	27/64 (42%)
		SH3_15	328..392	CDD:375773	29/65 (45%)
		PLN03192	<453..517	CDD:215625	18/77 (23%)
		PHA03095	486..>737	CDD:222980	104/252 (41%)
		ANK repeat	490..520	CDD:293786	10/29 (34%)
		ANK repeat	522..553	CDD:293786	8/30 (27%)
		ANK repeat	555..586	CDD:293786	15/30 (50%)
		ANK repeat	588..622	CDD:293786	12/33 (36%)
		ANK repeat	625..656	CDD:293786	12/32 (38%)
		ANK repeat	658..690	CDD:293786	17/31 (55%)
		ANK repeat	692..723	CDD:293786	14/30 (47%)
		RING1-HC_MIB2	858..894	CDD:319640	17/35 (49%)
		RING_Ubox	937..982	CDD:388418	21/45 (47%)
		RING-HC finger (C3HC4-type)	938..970	CDD:319361	15/31 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002693
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104088
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.710