DRSC/TRiP Functional Genomics Resources

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Protein Alignment mib1 and mib2

DIOPT Version :10

Sequence 1:NP_648826.2 Gene:mib1 / 39750 FlyBaseID:FBgn0263601 Length:1226 Species:Drosophila melanogaster
Sequence 2:NP_001073146.1 Gene:mib2 / 560887 ZFINID:ZDB-GENE-050628-1 Length:999 Species:Danio rerio


Alignment Length:1195 Identity:419/1195 - (35%)
Similarity:604/1195 - (50%) Gaps:248/1195 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 GSLPGGT----TSSSSASAAGGV----AAGGGGNSAAALVRRFSMEGVGARVIRGPDWKWNKQDG 125
            ||:|..|    .::|||.....:    .||..|..|     |.||| ||.||:||.||||..||.
Zfish    15 GSVPLATPPRPQTASSAPLPRPIRKHSEAGPSGQPA-----RGSME-VGMRVVRGADWKWANQDD 73

  Fly   126 GEGHVGTV----RNFESA---EEVVVVWDNGTAANYRCA--GAYDLRILDSAPTGVKHEGTMCDT 181
            ||||||||    |...:.   :.|||.||:||..|||..  ||:||.:.|:|..||:|...:||:
Zfish    74 GEGHVGTVVEIGRQGSTTTPDKTVVVQWDSGTRTNYRSGYQGAFDLLLYDNAQIGVRHSNIICDS 138

  Fly   182 CRQQPIFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRITTPGGERTMLEPRRKSKKVLARGIF 246
            |::..|.|:||||..|.:||||:.||..:||.|.|.|.|..|...:...|.||:...:::.:|||
Zfish   139 CKKHGIMGMRWKCKVCFDYDLCTQCYMNNKHGLTHAFERYETAHSQPVSLTPRQNLSRIILKGIF 203

  Fly   247 PGARVVRGVDWQWEDQDGGVGRRGKVNEIQDWSSASPRSAAYVIWDNGSKNLYRVGFEGMADLKV 311
            .|.:||||.||.|.:||||.|:.|||.:|:.|...|.||.|.|.|.|.:.|:||:|.:|..|||.
Zfish   204 QGVKVVRGPDWDWGNQDGGEGKVGKVVDIRGWDQESGRSVASVTWSNSTTNVYRMGHKGKVDLKY 268

  Fly   312 VNDAKGSNVYRDHLPLLGENG-----PGKGPHGFQIGDKVTVDLDLEIVQSLQHGHGGWTDGMFE 371
            |:|.:|...|::|||.|||:.     .....|.||.||||...|:::|::.:|.|||||...|.|
Zfish   269 VSDVQGGFYYKEHLPKLGEHAELQRQESADSHSFQQGDKVKCLLEVDILRQMQEGHGGWNPKMAE 333

  Fly   372 CLSNAGMVVGIDEDHDIVVAYNSGNRWTFNPAVLTKVSSPTTAPPEFQVGDIVKICSDVESIKIL 436
            .:|..|.|..|.:..|:.|.|::..||||:|..||||::       |.||::||:..|::|:|.|
Zfish   334 YISRIGTVHRITDRGDVRVQYSNNIRWTFHPGALTKVNT-------FAVGELVKVLDDIDSVKRL 391

  Fly   437 QRGHGEWADAMQLTLGKIGRVQQVYHDNDLKVEVGNTSWTYNPLAVCKVASSTASDGSCAPVIPS 501
            |.|||||.|:|...||::|:|.:||.|.||:|..|..:||:||  .|..|.....|.:...|..:
Zfish   392 QVGHGEWTDSMAPALGQVGKVLKVYADGDLRVAFGGQTWTFNP--ACLSAQPGEVDANLMTVENA 454

  Fly   502 SERLS---AILKKLFEPNVSGDATEEFVKAAANGFAARCEEYLAGAAQPSTSSASPSSGPD-VNV 562
            ||..|   ::|:||...:...|.....|..||:|.||:..|.|             ...|| |::
Zfish   455 SESSSTVISVLEKLLSQSTEQDNPGRLVIEAAHGSAAKVRELL-------------QKHPDKVDI 506

  Fly   563 NGVFAGHTALQAASQNGHIEVIQVLLRHAVDVEIEDKDGDRAVHHAAFGDEAAVIEILAKAGADL 627
            ..  .|.||||.|:..||:||::|||:....:|.:|:|||.|:|:.|||::|.:..:|...||.:
Zfish   507 KN--QGKTALQVAAHQGHVEVVKVLLQANSSIEAKDEDGDAALHYTAFGNQAEIARLLLSKGASV 569

  Fly   628 NARNKRRQTSLHIAVNKGHLNVVKTLLTLGCHPSLQDSEGDTPLHDAISKEHDEMLSLL-----L 687
            |..|....|:||||||||..:||:.|.......:||||.|||||||||:|:...::.:|     :
Zfish   570 NLLNNSMCTALHIAVNKGFTDVVRVLTEHSADVNLQDSYGDTPLHDAIAKDFRSIIEILTVVPNI 634

  Fly   688 DFGADITLNNNNGFNALHHAALKGNPSAMKILLTKTNRPWIVEEKKDDGYTALHLAALNNHVEIA 752
            ||    |..||.|||.|||||||||..|.:::|::..:  :.:.||:||::||||||||||.::|
Zfish   635 DF----TQQNNRGFNLLHHAALKGNKLATEMILSRARQ--LADVKKEDGFSALHLAALNNHRDVA 693

  Fly   753 ELLVHMGKANMDRQNVNLQTALHLAVERQHVQIVKLLVQDGADLNIPDKDGDTPLHEALRHHTLS 817
            |:|:..|:.:::.:|...||.|.|||.:.|:.:|.|||.:|||:|..|:||||.:|.:|....|:
Zfish   694 EILLKEGRCDINIRNNRNQTPLQLAVTQGHMALVALLVMEGADVNAEDEDGDTAMHTSLSRQQLT 758

  Fly   818 QLKQLQDVEGFGKLL------MGLRNANNKKASASIACFLAANGADLTLKNRKQQTPLDLCPDPN 876
            .:  :...||.|.:|      .||.........|:||||||..|||::..|.|.::||||..|.:
Zfish   759 TV--ISSAEGDGAVLYGRLCSSGLMGNTELNVGAAIACFLAQEGADISYANHKGKSPLDLVTDSS 821

  Fly   877 LCKTLVKCYNERKTDDSELPGNVAGTSSSARARAASGSLNQSSSVNMPLSSLAASSTFPAASSSS 941
            : :||::.:.|:    ..|.....||.||    ::|.||.:..:....:::||.    |:.:..|
Zfish   822 V-QTLIRSFAEK----HRLHAVSCGTGSS----SSSSSLRRVHTTPNTMTNLAV----PSVTGPS 873

  Fly   942 IFALNGIANEMSQSLHEDPPKSSASLDECLVCSDAKRDTVFKPCGHVSCCETCAPRVKKCLICRE 1006
                                                                             
Zfish   874 ----------------------------------------------------------------- 873

  Fly  1007 TVSSREKIDECLVCSDRRAAVFFRPCGHMVACEHCSALMKKCVLCRTQIDEILSFSLCCGGSGRP 1071
                     |||:||:....|.|.||.|.||||.|:..||||:.|:..|.:.:          |.
Zfish   874 ---------ECLICSELALLVLFSPCQHSVACEECAHRMKKCIRCQVTITKKI----------RQ 919

  Fly  1072 EKVSVAAGAMATVGLPLPDDRFMEAAAAAACANASGHSVAMNNTVVTPVAGSSNQLNSQNNLLAA 1136
            ::..|..                                                          
Zfish   920 DQTEVEC---------------------------------------------------------- 926

  Fly  1137 AAASSNVSNLSAAGNAMVAPSNVNNFQMDDVQKLKQQLQDIKEQTMCPVCFDRIKNMVFLCGHGT 1201
                              :||:.|:.|...:::|:.:.:.::|:..||:|.|....:||.|||.:
Zfish   927 ------------------SPSSENSEQHHLLEQLQSRYRQMEERITCPICIDNHIRLVFQCGHAS 973

  Fly  1202 CQMCGDQIEGCPICRKTVEKRILLF 1226
            |..|...::.|||||:|:.:||.||
Zfish   974 CIDCSSALKTCPICRQTIRERIQLF 998

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mib1NP_648826.2 MIB_HERC2 109..166 CDD:461991 34/65 (52%)
ZZ_Mind_bomb 177..221 CDD:239079 21/43 (49%)
MIB_HERC2 248..313 CDD:461991 33/64 (52%)
SH3_15 340..405 CDD:465720 28/64 (44%)
SH3_15 418..482 CDD:465720 32/63 (51%)
ANKYR 559..824 CDD:440430 119/270 (44%)
ANK repeat 568..598 CDD:293786 14/29 (48%)
ANK repeat 600..631 CDD:293786 13/30 (43%)
ANK repeat 633..664 CDD:293786 13/30 (43%)
ANK repeat 666..695 CDD:293786 13/33 (39%)
ANK repeat 699..733 CDD:293786 14/33 (42%)
ANK repeat 735..767 CDD:293786 16/31 (52%)
ANK repeat 769..800 CDD:293786 15/30 (50%)
ANK repeat 802..862 CDD:293786 23/65 (35%)
RING-HC_MIB1_rpt1 968..1005 CDD:438384 0/36 (0%)
RING-HC_MIB1_rpt2 1015..1052 CDD:438385 19/36 (53%)
RING-HC_MIB1_rpt3 1181..1226 CDD:438387 19/44 (43%)
mib2NP_001073146.1 MIB_HERC2 57..123 CDD:461991 34/65 (52%)
ZZ_Mind_bomb 134..178 CDD:239079 21/43 (49%)
MIB_HERC2 205..269 CDD:461991 33/63 (52%)
SH3_15 302..367 CDD:465720 28/64 (44%)
SH3_15 373..437 CDD:465720 32/65 (49%)
ANKYR 462..749 CDD:440430 129/307 (42%)
ANK repeat 481..508 CDD:293786 11/39 (28%)
ANK repeat 510..540 CDD:293786 14/29 (48%)
ANK repeat 542..573 CDD:293786 13/30 (43%)
ANK repeat 575..606 CDD:293786 13/30 (43%)
ANK repeat 642..674 CDD:293786 14/33 (42%)
ANK repeat 676..708 CDD:293786 16/31 (52%)
ANK repeat 710..741 CDD:293786 15/30 (50%)
Ank_2 715..803 CDD:463710 36/89 (40%)
RING-HC_MIB2_rpt1 873..910 CDD:438386 20/110 (18%)
RING-HC_MIB2_rpt2 949..999 CDD:438388 22/50 (44%)

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