DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mib1 and Mib2

DIOPT Version :9

Sequence 1:	NP_648826.2	Gene:	mib1 / 39750	FlyBaseID:	FBgn0263601	Length:	1226	Species:	Drosophila melanogaster
Sequence 2:	XP_006239651.1	Gene:	Mib2 / 474147	RGDID:	1359469	Length:	982	Species:	Rattus norvegicus

Alignment Length:	1175	Identity:	389/1175 - (33%)
Similarity:	558/1175 - (47%)	Gaps:	260/1175 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 VGARVIRGPDWKWNKQDGGEGHVGTV----RNFESA---EEVVVVWDNGTAANYRCA--GAYDLR 163
            ||.||:||.||||.:||||||.||||    |:...:   ..|||.||.||..|||..  ||:||.
  Rat    11 VGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLL 75

  Fly   164 ILDSAPTGVKHEGTMCDTCRQQPIFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRITTPGGER 228
            :.|:|..|::|...:||.|::..:.|:||||..|.:||||:.||..:||.|.|.|.|..|.....
  Rat    76 LYDNAQIGIRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETSHSRP 140

  Fly   229 TMLEPRRKSKKVLARGIFPGARVVRGVDWQWEDQDGGVGRRGKVNEIQDWSSASPRSAAYVIWDN 293
            ..|.||:...::..||||.||:||||.||:|..||||.|:.|:|.:|:.|...:.||.|.|.|.:
  Rat   141 VTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASVTWAD 205

  Fly   294 GSKNLYRVGFEGMADLKVVNDAKGSNVYRDHLPLLGE--------NGPGKGPHGFQIGDKVTVDL 350
            |:.|:||||.:|..|||.|.:|.|...|::|||.||:        :..|:   .||.||||...|
  Rat   206 GTTNVYRVGHKGKVDLKCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQ---PFQRGDKVKCLL 267

  Fly   351 DLEIVQSLQHGHGGWTDGMFECLSNAGMVVGIDEDHDIVVAYNSGNRWTFNPAVLTKVSSPTTAP 415
            |.::::.:|.|||||...|.|.:...|.|..|.:..|:.|.:|...||||:|..|||.:|
  Rat   268 DTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQFNHETRWTFHPGALTKHNS----- 327

  Fly   416 PEFQVGDIVKICSDVESIKILQRGHGEWADAMQLTLGKIGRVQQVYHDNDLKVEVGNTSWTYNP- 479
              |.|||:|::..|::::|.||.|||||.|.|...||::|:|.:|:.|.:|:|.||...||::|
  Rat   328 --FWVGDVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVGGQRWTFSPA 390

  Fly   480 -LAVCK--------VASSTASDGSCA-----------------PVIPSSERLSAILKKLFEPNVS 518
             |..|:        ||.....:.|.|                 |.:|... ||..|.||......
  Rat   391 CLVACRPEEDANLGVAERARENKSAASVPVAGGRQGRPWPALTPTLPPGS-LSVALDKLRTQKSD 454

  Fly   519 GDATEEFVKAAANGFAARCEEYLAGAAQPSTSSASPSSGPDVNVNGVFAGHTALQAASQNGHIEV 583
            .:.....|..||.|..||..:.|....:              .|:....|.||||.|:..|.:|:
  Rat   455 PEHPGRLVVEAALGNVARALDLLRRHPE--------------QVDTKNQGRTALQVAAYLGQVEL 505

  Fly   584 IQVLLRHAVDVEIEDKDGDRAVHHAAFGDEAAVIEILAKAGADLNARNKRRQTSLHIAVNKGHLN 648
            :::||:....|::.|::|:.|:|:.|.|::.....:|..||..::|:|..|.|:||:||.:|.|.
  Rat   506 VRLLLQARASVDLLDEEGNTALHYTAMGNQPEATRLLLSAGCGVDAQNGTRSTALHVAVQRGFLE 570

  Fly   649 VVKTLLTLGCHPSLQDSEGDTPLHDAIS--KEHDEMLSLLLDF-GADITLNNNNGFNALHHAALK 710
            |||.|...||..:|.|:..|||||.|||  .....::.:|.:. |.|:|..|:.||..||||:||
  Rat   571 VVKILCEHGCDVNLPDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASLK 635

  Fly   711 GNPSAMKILLTKTNRPWIVEEKKDDGYTALHLAALNNHVEIAELLVHMGKANMDRQNVNLQTALH 775
            |:..|::.:|.:..:  :|:.||:||:|||||||||||.|:|::|:..|:.:::.:|..||:.||
  Rat   636 GHVLAVRKILARARQ--LVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPLH 698

  Fly   776 LAVERQHVQIVKLLVQDGADLNIPDKDGDTPLHEALRHHTLSQLKQLQDVEGF--GKLLM----- 833
            |||::.|:.:|.|||..|.::|..|::|||.||.||:.|.|  |..:.|..|.  |.|.:
  Rat   699 LAVQQAHLGLVPLLVDAGCNVNTEDEEGDTALHVALQRHQL--LPLVADRAGGDPGPLQLLSRLQ 761

  Fly   834 --GLRNANNKKASASIACFLAANGADLTLKNRKQQTPLDLCPDPNLCKTLVKCYNERKTDDSELP 896
              ||..:......|::|||||..|||::..|.:.::||||..:..:.|.|..|
  Rat   762 ASGLPGSTELTVGAAVACFLALEGADVSYANHRGRSPLDLATEGRVLKALQGC------------ 814

  Fly   897 GNVAGTSSSARARAASGSLNQSSSVNMPLSSLAASSTFPAASSSSIFALNGIANEMSQSLHEDPP 961
                  :...|.|.|.|...........||:                                 |
  Rat   815 ------AQRFRERQAGGGGGVPPGPRHVLST---------------------------------P 840

  Fly   962 KSSASLDECLVCSDAKRDTVFKPCGHVSCCETCAPRVKKCLICRETVSSREKIDECLVCSDRRAA 1026
            .:..:|                   |||  .|..|...                ||||||:....
  Rat   841 NTVTNL-------------------HVS--GTAGPEAA----------------ECLVCSELALL 868

  Fly  1027 VFFRPCGHMVACEHCSALMKKCVLCRTQIDEILSFSLCCGGSGRPEKVSVAAGAMATVGLPLPDD 1091
            |.|.||.|...||.|:..||||:.|:..|.:.|          ||:...|.
  Rat   869 VLFSPCQHRTVCEECARRMKKCIRCQVIISKKL----------RPDGSEVV-------------- 909

  Fly  1092 RFMEAAAAAACANASGHSVAMNNTVVTPVAGSSNQLNSQNNLLAAAAASSNVSNLSAAGNAMVAP 1156
                                  |.:..|  |...||
  Rat   910 ----------------------NAIQVP--GPPRQL----------------------------- 921

  Fly  1157 SNVNNFQMDDVQKLKQQLQDIKEQTMCPVCFDRIKNMVFLCGHGTCQMCGDQIEGCPICRKTVEK 1221
                      |::|:.:.:.::|:..||:|.|....:||.||||.|..||..:..|||||:.:..
  Rat   922 ----------VEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRD 976

  Fly  1222 RILLF 1226
            ||.:|
  Rat   977 RIQIF 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib1	NP_648826.2	MIB_HERC2	109..165	CDD:284184	34/64 (53%)
		ZZ_Mind_bomb	177..221	CDD:239079	20/43 (47%)
		MIB_HERC2	248..312	CDD:284184	33/63 (52%)
		Ank_4	568..620	CDD:290365	17/51 (33%)
		ANK repeat	568..598	CDD:293786	11/29 (38%)
		ANK repeat	600..631	CDD:293786	9/30 (30%)
		Ank_2	606..697	CDD:289560	36/93 (39%)
		ANK	628..756	CDD:238125	60/130 (46%)
		ANK repeat	633..664	CDD:293786	15/30 (50%)
		ANK repeat	666..695	CDD:293786	11/31 (35%)
		ANK repeat	699..733	CDD:293786	12/33 (36%)
		Ank_2	704..800	CDD:289560	44/95 (46%)
		ANK	734..872	CDD:238125	62/146 (42%)
		ANK repeat	735..767	CDD:293786	17/31 (55%)
		ANK repeat	769..800	CDD:293786	14/30 (47%)
		Ank_2	774..862	CDD:289560	38/96 (40%)
		ANK repeat	802..862	CDD:293786	25/68 (37%)
		zf-C3HC4_3	968..1011	CDD:290631	5/42 (12%)
		zf-C3HC4_3	1013..1058	CDD:290631	20/44 (45%)
		zf-C3HC4_3	1179..1222	CDD:290631	19/42 (45%)
Mib2	XP_006239651.1	MIB_HERC2	12..78	CDD:399589	34/65 (52%)
		ZZ_Mind_bomb	89..133	CDD:239079	20/43 (47%)
		MIB_HERC2	160..224	CDD:399589	33/63 (52%)
		SH3_15	257..322	CDD:408152	27/64 (42%)
		SH3_15	328..392	CDD:408152	29/63 (46%)
		PLN03192	<453..517	CDD:215625	18/77 (23%)
		PHA03095	486..>737	CDD:222980	105/252 (42%)
		ANK repeat	490..520	CDD:293786	11/29 (38%)
		ANK repeat	522..553	CDD:293786	9/30 (30%)
		ANK repeat	555..586	CDD:293786	15/30 (50%)
		ANK repeat	588..622	CDD:293786	12/33 (36%)
		ANK repeat	625..656	CDD:293786	12/32 (38%)
		ANK repeat	658..690	CDD:293786	17/31 (55%)
		ANK repeat	692..723	CDD:293786	14/30 (47%)
		RING1-HC_MIB2	858..894	CDD:319640	18/35 (51%)
		RING_Ubox	937..982	CDD:418438	21/45 (47%)
		RING-HC finger (C3HC4-type)	938..970	CDD:319361	15/31 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119594at33208
OrthoFinder	1	1.000	-	-		FOG0002693
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104088
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720