DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mib1 and sqstm1

DIOPT Version :9

Sequence 1:	NP_648826.2	Gene:	mib1 / 39750	FlyBaseID:	FBgn0263601	Length:	1226	Species:	Drosophila melanogaster
Sequence 2:	NP_001299842.1	Gene:	sqstm1 / 406452	ZFINID:	ZDB-GENE-040426-2204	Length:	452	Species:	Danio rerio

Alignment Length:	397	Identity:	85/397 - (21%)
Similarity:	123/397 - (30%)	Gaps:	151/397 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 PTGVKHEGTMCDTCRQQPIFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRITTPGGERTMLEP 233
            |..:.|.|..||.| ..|:.|.|:||..|.:||||..|.....|.             |..:|.
Zfish   140 PHPMVHPGVTCDGC-DGPVAGTRYKCTVCPDYDLCPTCQSKGLHK-------------EHALLP- 189

  Fly   234 RRKSKKVLARGIF-PGARVVRGVDWQWEDQDGGVGRRGKVNEIQDWSSASPRSAAYVIWDNGSKN 297
                       || |.|.|     ::|..       |||.     |     |...:.:|.|....
Zfish   190 -----------IFHPMANV-----FEWLP-------RGKF-----W-----RKMRHCMWANAQAQ 221

  Fly   298 LYRVGFEGMADLKVVNDAKGSNVYRDHLPLLGENGPGKGPHGFQIGDKVTVDLDLEIVQSLQHGH 362
                                           .:|.|..||.|.|.......:.:       ::|.
Zfish   222 -------------------------------AQNQPQPGPSGAQQNQDAPENPN-------ENGA 248

  Fly   363 GGWTDGMFECLSNAGMVV-------GIDEDHDIVVAYNSGNRWTFNPAVLTKVSSPTTAPPEFQV 420
            ...:....|.|.|.|..|       |||.|.|:   .:.|.|        |||   |..||....
Zfish   249 TASSQANVEYLKNIGEEVAAMLSPLGIDVDIDV---EHEGKR--------TKV---TPTPPASSG 299

  Fly   421 GDIVKICSDVESIKILQRGHGEWADAMQLTLGKIGRVQQVYHDNDLKVEVGNTSWTYNPLAVCKV 485
            ....:  ||..|:.:|.||.|..:.|          .::...:...|.:..:..||:  |:..:|
Zfish   300 PSSAR--SDSGSVGLLSRGSGPGSQA----------TEESVSEGTKKDQCSDEEWTH--LSAKEV 350

  Fly   486 ASSTA--------SDGSCAPVI------------PSSERLSAILKKLFEPNVSGDATEEFVKAAA 530
            ..||.        .||:..|..            |:..|.:|:.     |::..||....|::.:
Zfish   351 DPSTGELQSLRLEQDGADLPAPLNTASGTSTRDGPTGLREAALY-----PHLPQDADPRLVESLS 410

  Fly   531 N----GF 533
            .    ||
Zfish   411 QMLSMGF 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib1	NP_648826.2	MIB_HERC2	109..165	CDD:284184
		ZZ_Mind_bomb	177..221	CDD:239079	15/43 (35%)
		MIB_HERC2	248..312	CDD:284184	10/63 (16%)
		Ank_4	568..620	CDD:290365
		ANK repeat	568..598	CDD:293786
		ANK repeat	600..631	CDD:293786
		Ank_2	606..697	CDD:289560
		ANK	628..756	CDD:238125
		ANK repeat	633..664	CDD:293786
		ANK repeat	666..695	CDD:293786
		ANK repeat	699..733	CDD:293786
		Ank_2	704..800	CDD:289560
		ANK	734..872	CDD:238125
		ANK repeat	735..767	CDD:293786
		ANK repeat	769..800	CDD:293786
		Ank_2	774..862	CDD:289560
		ANK repeat	802..862	CDD:293786
		zf-C3HC4_3	968..1011	CDD:290631
		zf-C3HC4_3	1013..1058	CDD:290631
		zf-C3HC4_3	1179..1222	CDD:290631
sqstm1	NP_001299842.1	PB1_p62	3..88	CDD:99723
		ZZ_NBR1_like	148..190	CDD:239080	17/67 (25%)
		UBA_like_SF	390..448	CDD:304366	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900