Protein Alignment mib1 and Ank2

DIOPT Version :10

• Sequence 1: NP_648826.2
• Gene: mib1 / 39750
• FlyBaseID: FBgn0263601
• Length: 1226
• Species: Drosophila melanogaster
• Sequence 2: NP_001189070.1
• Gene: Ank2 / 38863
• FlyBaseID: FBgn0261788
• Length: 13559
• Species: Drosophila melanogaster
• Alignment Length: 616
• Identity: 151/616 - (24%)
• Similarity: 234/616 - (37%)
• Gaps: 184/616 - (29%)

  Fly   514 EPNVSGDATEEFVKAAANGFAARCEEYLAGAAQPSTSSASPSSGPDVNVNGVFAGHTALQAASQN 578
            |....||....|::||..|...|..|:|......:||          |.||:    .||..||::
  Fly     4 ENGAQGDGNTSFLRAARAGNLERVLEHLKNNIDINTS----------NANGL----NALHLASKD 54

  Fly   579 GHIEVIQVLLRHAVDVEIEDKDGDRAVHHAAFGDEAAVIEILAKAGADLNARNKRRQTSLHIAVN 643
            |||.|:..|||....|:...|.|:.|:|.|:...:..|:::|.:..|.:|.:::...|.|::|..
  Fly    55 GHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQ 119

  Fly   644 KGHLNVVKTLLTLGCHPSLQDSEGDTPLHDAISKEHDEMLSLLL--------------------- 687
            :.|..||:.||:.|.:.||...:|.|||..|:.:.||:::::||
  Fly   120 ENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDD 184

  Fly   688 ----------DFGADITLNNNNGFNALHHAALKGNPSAMKILLT--------------------- 721
                      |...|:|  :.:||..||.|:..||.:...:|:.
  Fly   185 VKAATLLLDNDHNPDVT--SKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAK 247

  Fly   722 --KTNRPWI-------VEEKKDDGYTALHLAALNNHVEIAELLVHMG------------------ 759
              |||...:       :|.|..||.|.||.||.:.|.::.::|:..|
  Fly   248 WGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAA 312

  Fly   760 --------------KANMDRQNVNLQTALHLAVERQHVQIVKLLVQDGADLNIPDKDGDTPLHEA 810
                          :|.:|...|:..||||:|....||::.|||:...||.|....:|.||||.|
  Fly   313 QGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIA 377

  Fly   811 ------------LRH------HTLSQLKQLQDVEGFGKLLMGLRNANNKKASASIACFLAANGAD 857
                        |||      .|.|.|..|. |..|    ||..|         |..:|..:.|.
  Fly   378 CKKNRLKVVELLLRHGASISATTESGLTPLH-VAAF----MGCMN---------IVIYLLQHDAS 428

  Fly   858 LTLKNRKQQTPLDLCPDPN---LCKTLVKCYNERKTDDSELPGNVAGTSSSARARAASGSLNQSS 919
            ..:...:.:|||.|....|   :.:.|::                .|....||||.....|:.:|
  Fly   429 PDVPTVRGETPLHLAARANQTDIIRILLR----------------NGAQVDARAREQQTPLHIAS 477

  Fly   920 ---SVNMPLSSLAASSTFPAASSSSIFALNGIANEMSQSLHEDPPKSSASLDECLVCSDAKRDTV 981
               :|::.:..|...:...|.:.....||:..|.|....:       :|.|.|.....||.....
  Fly   478 RLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEV-------AAVLIENGAALDAATKKG 535

  Fly   982 FKPC------GHVSCCETCAPRVKKCLICRE 1006
            |.|.      ||:        :|.:.|:.:|
  Fly   536 FTPLHLTAKYGHI--------KVAQLLLQKE 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mib1	NP_648826.2	MIB_HERC2	109..166	CDD:461991
		ZZ_Mind_bomb	177..221	CDD:239079
		MIB_HERC2	248..313	CDD:461991
		SH3_15	340..405	CDD:465720
		SH3_15	418..482	CDD:465720
		ANKYR	559..824	CDD:440430	99/375 (26%)
		ANK repeat	568..598	CDD:293786	12/29 (41%)
		ANK repeat	600..631	CDD:293786	8/30 (27%)
		ANK repeat	633..664	CDD:293786	11/30 (37%)
		ANK repeat	666..695	CDD:293786	11/59 (19%)
		ANK repeat	699..733	CDD:293786	12/63 (19%)
		ANK repeat	735..767	CDD:293786	12/63 (19%)
		ANK repeat	769..800	CDD:293786	13/30 (43%)
		ANK repeat	802..862	CDD:293786	21/77 (27%)
		RING-HC_MIB1_rpt1	968..1005	CDD:438384	9/42 (21%)
		RING-HC_MIB1_rpt2	1015..1052	CDD:438385
		RING-HC_MIB1_rpt3	1181..1226	CDD:438387
Ank2	NP_001189070.1	ANKYR	10..308	CDD:440430	80/313 (26%)
		ANK repeat	10..41	CDD:293786	10/40 (25%)
		ANK repeat	43..74	CDD:293786	14/34 (41%)
		ANK repeat	76..107	CDD:293786	8/30 (27%)
		ANK repeat	109..134	CDD:293786	8/24 (33%)
		ANK repeat	175..202	CDD:293786	3/28 (11%)
		ANKYR	190..473	CDD:440430	74/314 (24%)
		ANK repeat	204..235	CDD:293786	8/30 (27%)
		ANK repeat	237..268	CDD:293786	4/30 (13%)
		ANK repeat	270..300	CDD:293786	10/29 (34%)
		ANK repeat	303..367	CDD:293786	16/63 (25%)
		ANK repeat	369..400	CDD:293786	9/30 (30%)
		ANKYR	383..671	CDD:440430	47/221 (21%)
		ANK repeat	402..433	CDD:293786	11/44 (25%)
		ANK repeat	435..466	CDD:293786	8/46 (17%)
		ANK repeat	468..497	CDD:293786	4/28 (14%)
		ANK repeat	501..530	CDD:293786	7/35 (20%)
		ANK repeat	535..565	CDD:293786	7/32 (22%)
		ANK repeat	567..598	CDD:293786
		PHA03100	599..>773	CDD:476869
		ANK repeat	600..630	CDD:293786
		ANK repeat	633..662	CDD:293786
		ANK repeat	666..697	CDD:293786
		ANK repeat	699..730	CDD:293786
		ANK repeat	732..762	CDD:293786
		ZU5	930..1027	CDD:459941
		UPA_2	1253..1384	CDD:375346
		Death_ank	1417..1497	CDD:260029
		PTZ00121	<1443..2235	CDD:173412
		PTZ00449	<3292..3611	CDD:185628
		PTZ00449	<4400..4857	CDD:185628
		PTZ00449	<4908..5267	CDD:185628
		PTZ00108	<5179..5374	CDD:240271
		PTZ00108	<6034..6230	CDD:240271
		PTZ00449	<6620..6979	CDD:185628
		PTZ00108	<7119..7314	CDD:240271
		PTZ00108	<7347..7544	CDD:240271
		PTZ00108	<7651..7848	CDD:240271
		PTZ00449	<7804..8119	CDD:185628
		PTZ00108	<8183..8381	CDD:240271
		PTZ00449	<8430..8745	CDD:185628
		PTZ00449	<8784..9125	CDD:185628
		PTZ00449	<9028..9353	CDD:185628
		PHA03307	9225..>9575	CDD:223039
		PHA03307	9903..>10259	CDD:223039
		PTZ00108	<10177..10451	CDD:240271