DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mib1 and mib1

DIOPT Version :9

Sequence 1:	NP_648826.2	Gene:	mib1 / 39750	FlyBaseID:	FBgn0263601	Length:	1226	Species:	Drosophila melanogaster
Sequence 2:	XP_009295119.1	Gene:	mib1 / 352910	ZFINID:	ZDB-GENE-030404-2	Length:	1041	Species:	Danio rerio

Alignment Length:	1152	Identity:	727/1152 - (63%)
Similarity:	846/1152 - (73%)	Gaps:	145/1152 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 RFSMEGVGARVIRGPDWKWNKQDGGEGHVGTVRNFESAEEVVVVWDNGTAANYRCAGAYDLRILD 166
            |..||||||||||||||||.|||||||||||||:|||.|||||||||||||||||:||||:||||
Zfish     8 RVMMEGVGARVIRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDVRILD 72

  Fly   167 SAPTGVKHEGTMCDTCRQQPIFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRITTPGGERTML 231
            |||||:||:||||||||||||.|||||||||.|||||:.||||||||||||||||||||.||.:|
Zfish    73 SAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTTCYHGDKHHLRHRFYRITTPGSERVLL 137

  Fly   232 EPRRKSKKVLARGIFPGARVVRGVDWQWEDQDGGVGRRGKVNEIQDWSSASPRSAAYVIWDNGSK 296
            |.||||||:.|||||.|.||||||||||||||||.||||||.||||||:|||.|||||:||||:|
Zfish   138 ESRRKSKKITARGIFAGGRVVRGVDWQWEDQDGGNGRRGKVTEIQDWSAASPHSAAYVLWDNGAK 202

  Fly   297 NLYRVGFEGMADLKVVNDAKGSNVYRDHLPLLGENGPGKGPHGFQIGDKVTVDLDLEIVQSLQHG 361
            ||||||||||:|||.|.||||...||||.|:|||....:.|.|.||||.|.:|||||||||||||
Zfish   203 NLYRVGFEGMSDLKCVQDAKGGTFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHG 267

  Fly   362 HGGWTDGMFECLSNAGMVVGIDEDHDIVVAYNSGNRWTFNPAVLTKV----SSPTTAPPE----- 417
            ||||||||||.|:..|.|.||||||||||.|.||||||||||||||.    |....|..|
Zfish   268 HGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANVVRSGEVAAGAEGGSSQ 332

  Fly   418 FQVGDIVKICSDVESIKILQRGHGEWADAMQLTLGKIGRVQQVYHDNDLKVEVGNTSWTYNPLAV 482
            |.|||:|:||.|::.||:|||||||||:||..||||:|||||:|.|:||||||..|||||||.||
Zfish   333 FMVGDLVQICYDIDRIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAV 397

  Fly   483 CKVASS----TASDGSC---APVIPSSERLSAILKKLFEPNVSGDATEEFVKAAANGFAARCEEY 540
            .|||.:    |.:.|:.   :|.:| :||||.:||||||...|||..||.|||||||..|:.|:.
Zfish   398 TKVAPAGSAVTNASGAVLTESPSVP-AERLSQLLKKLFETQESGDINEELVKAAANGDLAKVEDI 461

  Fly   541 LAGAAQPSTSSASPSSGPDVNVNGVFAGHTALQAASQNGHIEVIQVLLRHAVDVEIEDKDGDRAV 605
            |              ..|||:|||..|||||:||||||||::|:::||:|:||:|.|||||||||
Zfish   462 L--------------KRPDVDVNGQCAGHTAMQAASQNGHVDVLKLLLKHSVDLEAEDKDGDRAV 512

  Fly   606 HHAAFGDEAAVIEILAKAGADLNARNKRRQTSLHIAVNKGHLNVVKTLLTLGCHPSLQDSEGDTP 670
            |||:||||.:|||:|.:.|||||||||||||.||||||||||.||||||..||||||||||||||
Zfish   513 HHASFGDEGSVIEVLHRGGADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTP 577

  Fly   671 LHDAISKEHDEMLSLLLDFGADITLNNNNGFNALHHAALKGNPSAMKILLTKTNRPWIVEEKKDD 735
            |||||||:.|:|||:||:.|||:|:.|||||||||||||:||||||::||:|..|||||:|||||
Zfish   578 LHDAISKKRDDMLSVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDD 642

  Fly   736 GYTALHLAALNNHVEIAELLVHMGKANMDRQNVNLQTALHLAVERQHVQIVKLLVQDGADLNIPD 800
            |||||||||||||||:||||||.|.||:|.||||.||||||||||||.|||:|||:..|.|::.|
Zfish   643 GYTALHLAALNNHVEVAELLVHQGNANLDVQNVNQQTALHLAVERQHTQIVRLLVRAEAKLDVQD 707

  Fly   801 KDGDTPLHEALRHHTLSQLKQLQDVEGFGK----------LLMGL-RNANNKKASASIACFLAAN 854
            |||||||||||||||||||:||||::...|          |:||| .....||::||||||||||
Zfish   708 KDGDTPLHEALRHHTLSQLRQLQDMQDVSKVEPWEPSKNTLIMGLGTQGAEKKSAASIACFLAAN 772

  Fly   855 GADLTLKNRKQQTPLDLCPDPNLCKTLVKCYNERKTDDSELPGNVAGTSSSARARAASGSLNQSS 919
            |||||::|:|.|:||||||||:|||.|.||:.|:               :|.:..:.|.|||.:
Zfish   773 GADLTIRNKKGQSPLDLCPDPSLCKALAKCHKEK---------------TSGQVGSRSPSLNSN- 821

  Fly   920 SVNMPLSSLAASSTFPAASSSSIFALNGIANEMSQSLHEDPPKSSASLDECLVCSDAKRDTVFKP 984
                                          ||              :|:||:||||.||||:|.|
Zfish   822 ------------------------------NE--------------TLEECMVCSDMKRDTLFGP 842

  Fly   985 CGHVSCCETCAPRVKKCLICRETVSSREKIDECLVCSDRRAAVFFRPCGHMVACEHCSALMKKCV 1049
            |||::.|..|:|||||||||:|.|.||.||:||:||||::|||.|:|||||.|||:|::||||||
Zfish   843 CGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCV 907

  Fly  1050 LCRTQIDEILSFSLCCGGSGRPEKVSVAAGAMATVGLPLPDDRFMEAAAAAACANASGHSVAMNN 1114
            .||..::....|.|||||.|..:         ||      ||.           :.:|.|.:|
Zfish   908 QCRAVVERRTPFVLCCGGKGMED---------AT------DDE-----------DLTGGSNSM-- 944

  Fly  1115 TVVTPVAGSSNQLNSQNNLLAAAAASSNVSNLSAAGNAMVAPSNVNNFQMDDVQKLKQQLQDIKE 1179
                  ||.|..|...|| ||.:.:|.|:..|....:    .:|||    .|||||:||||||||
Zfish   945 ------AGGSQDLLQPNN-LALSWSSGNIPALQRDKD----NTNVN----ADVQKLQQQLQDIKE 994

  Fly  1180 QTMCPVCFDRIKNMVFLCGHGTCQMCGDQIEGCPICRKTVEKRILLF 1226
            |||||||.||:|||:|:|||||||:|||::..||||||.:|:||||:
Zfish   995 QTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICRKAIERRILLY 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib1	NP_648826.2	MIB_HERC2	109..165	CDD:284184	50/55 (91%)
		ZZ_Mind_bomb	177..221	CDD:239079	39/43 (91%)
		MIB_HERC2	248..312	CDD:284184	55/63 (87%)
		Ank_4	568..620	CDD:290365	38/51 (75%)
		ANK repeat	568..598	CDD:293786	19/29 (66%)
		ANK repeat	600..631	CDD:293786	23/30 (77%)
		Ank_2	606..697	CDD:289560	71/90 (79%)
		ANK	628..756	CDD:238125	106/127 (83%)
		ANK repeat	633..664	CDD:293786	26/30 (87%)
		ANK repeat	666..695	CDD:293786	21/28 (75%)
		ANK repeat	699..733	CDD:293786	26/33 (79%)
		Ank_2	704..800	CDD:289560	74/95 (78%)
		ANK	734..872	CDD:238125	103/148 (70%)
		ANK repeat	735..767	CDD:293786	26/31 (84%)
		ANK repeat	769..800	CDD:293786	21/30 (70%)
		Ank_2	774..862	CDD:289560	63/98 (64%)
		ANK repeat	802..862	CDD:293786	44/70 (63%)
		zf-C3HC4_3	968..1011	CDD:290631	28/42 (67%)
		zf-C3HC4_3	1013..1058	CDD:290631	29/44 (66%)
		zf-C3HC4_3	1179..1222	CDD:290631	31/42 (74%)
mib1	XP_009295119.1	MIB_HERC2	15..71	CDD:284184	50/55 (91%)
		ZZ_Mind_bomb	83..127	CDD:239079	39/43 (91%)
		MIB_HERC2	154..218	CDD:284184	55/63 (87%)
		Ank_2	446..571	CDD:289560	83/124 (67%)
		ANK repeat	475..538	CDD:293786	45/62 (73%)
		ANK	475..503	CDD:197603	18/27 (67%)
		ANK	535..663	CDD:238125	106/127 (83%)
		ANK repeat	540..571	CDD:293786	26/30 (87%)
		Ank_2	545..637	CDD:289560	73/91 (80%)
		ANK repeat	573..604	CDD:293786	21/30 (70%)
		ANK repeat	606..640	CDD:293786	26/33 (79%)
		Ank_2	611..707	CDD:289560	73/95 (77%)
		ANK	637..790	CDD:238125	115/163 (71%)
		ANK repeat	642..674	CDD:293786	26/31 (84%)
		ANK repeat	676..707	CDD:293786	20/30 (67%)
		Ank_2	681..780	CDD:289560	70/109 (64%)
		zf-C3HC4_3	826..869	CDD:290631	2/42 (5%)
		zf-C3HC4_3	871..916	CDD:290631	29/44 (66%)
		zf-C3HC4_3	994..1037	CDD:290631	9/42 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575815
Domainoid	1	1.000	125	1.000	Domainoid score	I5427
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10810
Inparanoid	1	1.050	1417	1.000	Inparanoid score	I116
OMA	1	1.010	-	-		QHG46014
OrthoDB	1	1.010	-	-		D119594at33208
OrthoFinder	1	1.000	-	-		FOG0002693
OrthoInspector	1	1.000	-	-		oto40926
orthoMCL	1	0.900	-	-		OOG6_104088
Panther	1	1.100	-	-	LDO	PTHR24202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4659
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.440