DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mib1 and Mib1

DIOPT Version :9

Sequence 1:	NP_648826.2	Gene:	mib1 / 39750	FlyBaseID:	FBgn0263601	Length:	1226	Species:	Drosophila melanogaster
Sequence 2:	NP_001100875.1	Gene:	Mib1 / 307594	RGDID:	1307195	Length:	1006	Species:	Rattus norvegicus

Alignment Length:	1149	Identity:	712/1149 - (61%)
Similarity:	826/1149 - (71%)	Gaps:	174/1149 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 RFSMEGVGARVIRGPDWKWNKQDGGEGHVGTVRNFESAEEVVVVWDNGTAANYRCAGAYDLRILD 166
            |..:|||||||:|||||||.|||||||||||||:|||.|||||||||||||||||:|||||||||
  Rat     8 RVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILD 72

  Fly   167 SAPTGVKHEGTMCDTCRQQPIFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRITTPGGERTML 231
            |||||:||:||||||||||||.|||||||||.|||||::||||||||||||||||||||.||.:|
  Rat    73 SAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLL 137

  Fly   232 EPRRKSKKVLARGIFPGARVVRGVDWQWEDQDGGVGRRGKVNEIQDWSSASPRSAAYVIWDNGSK 296
            |.||||||:.|||||.||||||||||||||||||.||||||.||||||::||.|||||:||||:|
  Rat   138 ESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAK 202

  Fly   297 NLYRVGFEGMADLKVVNDAKGSNVYRDHLPLLGENGPGKGPHGFQIGDKVTVDLDLEIVQSLQHG 361
            ||||||||||:|||.|.||||.:.||||.|:|||....:.|.|.||||.|.:|||||||||||||
  Rat   203 NLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHG 267

  Fly   362 HGGWTDGMFECLSNAGMVVGIDEDHDIVVAYNSGNRWTFNPAVLTK---VSSPTTA------PPE 417
            ||||||||||.|:..|.|.||||||||||.|.||||||||||||||   |.|...|      ..:
  Rat   268 HGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQ 332

  Fly   418 FQVGDIVKICSDVESIKILQRGHGEWADAMQLTLGKIGRVQQVYHDNDLKVEVGNTSWTYNPLAV 482
            |||||:|::|.|:|.||:|||||||||:||..||||:|||||:|.|:||||||..|||||||.||
  Rat   333 FQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAV 397

  Fly   483 CKV--ASSTASDGSCAPVIPSSERLSAILKKLFEPNVSGDATEEFVKAAANGFAARCEEYLAGAA 545
            .||  |.||.|:.       |.||||.:||||||...|||..||.|||||||..|:.|:.|
  Rat   398 SKVAPAGSTISNA-------SGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLL---- 451

  Fly   546 QPSTSSASPSSGPDVNVNGVFAGHTALQAASQNGHIEVIQVLLRHAVDVEIEDKDGDRAVHHAAF 610
                      ..|||:|||..|||||:||||||||::::::||:..||||.||||||||||||||
  Rat   452 ----------KRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAF 506

  Fly   611 GDEAAVIEILAKAGADLNARNKRRQTSLHIAVNKGHLNVVKTLLTLGCHPSLQDSEGDTPLHDAI 675
            |||.||||:|.:..||||||||||||.||||||||||.||||||..|||||||||||||||||||
  Rat   507 GDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAI 571

  Fly   676 SKEHDEMLSLLLDFGADITLNNNNGFNALHHAALKGNPSAMKILLTKTNRPWIVEEKKDDGYTAL 740
            ||:.|::|::||:.|||:|:.|||||||||||||:||||||::||:|..|||||:||||||||||
  Rat   572 SKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTAL 636

  Fly   741 HLAALNNHVEIAELLVHMGKANMDRQNVNLQTALHLAVERQHVQIVKLLVQDGADLNIPDKDGDT 805
            ||||||||||:||||||.|.||:|.||||.||||||||||||.|||:|||:.||.|:|.||||||
  Rat   637 HLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDT 701

  Fly   806 PLHEALRHHTLSQLKQLQDVEGFGK-----------LLMGL-RNANNKKASASIACFLAANGADL 858
            ||||||||||||||:||||::..||           |:||| .....||::||||||||||||||
  Rat   702 PLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADL 766

  Fly   859 TLKNRKQQTPLDLCPDPNLCKTLVKCYNERKTDDSELPGNVAGTSSSARARAASGSLNQSSSVNM 923
            :::|:|.|:||||||||:|||.|.||:.|:      :.|.|...|.|.
  Rat   767 SIRNKKGQSPLDLCPDPSLCKALAKCHKEK------VSGQVGSRSPSM----------------- 808

  Fly   924 PLSSLAASSTFPAASSSSIFALNGIANEMSQSLHEDPPKSSASLDECLVCSDAKRDTVFKPCGHV 988
                                    |:|:            |.:|:||:||||.||||:|.||||:
  Rat   809 ------------------------ISND------------SETLEECMVCSDMKRDTLFGPCGHI 837

  Fly   989 SCCETCAPRVKKCLICRETVSSREKIDECLVCSDRRAAVFFRPCGHMVACEHCSALMKKCVLCRT 1053
            :.|..|:|||||||||:|.|.||.||:||:||||::|||.|:|||||.|||:|::||||||.||.
  Rat   838 ATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCRA 902

  Fly  1054 QIDEILSFSLCCGGSGRPEKVSVAAGAMATVGLPLPDDRFMEAAAAAACANASGHSVAMNNTVVT 1118
            .::..:.|..||||....|                |.|..
  Rat   903 VVERRVPFITCCGGKSSEE----------------PSDDI------------------------- 926

  Fly  1119 PVAGSSNQLNSQNNLLAAAAASSNVSNLSAAGNAMVAPSNVNNFQMD-DVQKLKQQLQDIKEQTM 1182
                                         ::||..|...:.:|..:: |||||:|||||||||||
  Rat   927 -----------------------------SSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTM 962

  Fly  1183 CPVCFDRIKNMVFLCGHGTCQMCGDQIEGCPICRKTVEKRILLF 1226
            ||||.||:|||:|||||||||:|||::..||||||.:|:||||:
  Rat   963 CPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib1	NP_648826.2	MIB_HERC2	109..165	CDD:284184	50/55 (91%)
		ZZ_Mind_bomb	177..221	CDD:239079	39/43 (91%)
		MIB_HERC2	248..312	CDD:284184	55/63 (87%)
		Ank_4	568..620	CDD:290365	39/51 (76%)
		ANK repeat	568..598	CDD:293786	18/29 (62%)
		ANK repeat	600..631	CDD:293786	24/30 (80%)
		Ank_2	606..697	CDD:289560	70/90 (78%)
		ANK	628..756	CDD:238125	104/127 (82%)
		ANK repeat	633..664	CDD:293786	26/30 (87%)
		ANK repeat	666..695	CDD:293786	19/28 (68%)
		ANK repeat	699..733	CDD:293786	26/33 (79%)
		Ank_2	704..800	CDD:289560	76/95 (80%)
		ANK	734..872	CDD:238125	105/149 (70%)
		ANK repeat	735..767	CDD:293786	26/31 (84%)
		ANK repeat	769..800	CDD:293786	23/30 (77%)
		Ank_2	774..862	CDD:289560	65/99 (66%)
		ANK repeat	802..862	CDD:293786	44/71 (62%)
		zf-C3HC4_3	968..1011	CDD:290631	28/42 (67%)
		zf-C3HC4_3	1013..1058	CDD:290631	29/44 (66%)
		zf-C3HC4_3	1179..1222	CDD:290631	32/42 (76%)
Mib1	NP_001100875.1	MIB_HERC2	15..72	CDD:399589	51/56 (91%)
		ZZ_Mind_bomb	83..127	CDD:239079	39/43 (91%)
		MIB_HERC2	154..218	CDD:399589	55/63 (87%)
		SH3_15	246..311	CDD:408152	52/64 (81%)
		SH3_15	333..397	CDD:408152	46/63 (73%)
		PHA03095	439..>710	CDD:222980	207/284 (73%)
		ANK repeat	464..494	CDD:293786	18/29 (62%)
		ANK repeat	496..560	CDD:293786	53/63 (84%)
		ANK repeat	562..593	CDD:293786	20/30 (67%)
		ANK repeat	631..663	CDD:293786	26/31 (84%)
		ANK repeat	665..696	CDD:293786	23/30 (77%)
		Ank_2	670..770	CDD:403870	65/99 (66%)
		RING1-HC_MIB1	818..854	CDD:319638	25/35 (71%)
		RING2-HC_MIB1	865..901	CDD:319639	25/35 (71%)
		RING3-HC_MIB1	962..1003	CDD:319641	29/40 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336662
Domainoid	1	1.000	126	1.000	Domainoid score	I5311
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10810
Inparanoid	1	1.050	1310	1.000	Inparanoid score	I138
OMA	1	1.010	-	-		QHG46014
OrthoDB	1	1.010	-	-		D119594at33208
OrthoFinder	1	1.000	-	-		FOG0002693
OrthoInspector	1	1.000	-	-		oto96631
orthoMCL	1	0.900	-	-		OOG6_104088
Panther	1	1.100	-	-	LDO	PTHR24202
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770