DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mib1 and Nbr1

DIOPT Version :9

Sequence 1:	NP_648826.2	Gene:	mib1 / 39750	FlyBaseID:	FBgn0263601	Length:	1226	Species:	Drosophila melanogaster
Sequence 2:	NP_001019936.1	Gene:	Nbr1 / 303554	RGDID:	69195	Length:	983	Species:	Rattus norvegicus

Alignment Length:	738	Identity:	146/738 - (19%)
Similarity:	228/738 - (30%)	Gaps:	225/738 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 PVIPSSE----------RLSAILKKLFEPNVSGDATEEFVKAAANGFAARCEE------------ 539
            ||:.|||          ||.|.|:::   .:.....:.||||......|..::
  Rat   264 PVVISSEPFFYSKYPTPRLPAALEQV---RLQKQVDKNFVKAEKQRLRAEKKQRKAEVKELKKQL 325

  Fly   540 ------YLAGAAQPSTSSASPSSGPDVNVNGVFAGHT---ALQAASQNGHIEVIQVLLRHAVDVE 595
                  :|..:.....|..||...|:    .:...:|   .||..:     .|:..|....||..
  Rat   326 KLHRKIHLWNSIHGLQSPKSPLGRPE----SLLQSNTLMLPLQPCA-----PVMPTLSAAFVDEN 381

  Fly   596 IED----KDGDRAVHHAAFGDEAAVIEILAKAGAD---------LNARNKRRQTSLHIAVNKGHL 647
            :.|    :.|.:.:.|....:...|     |..||         |...:..::..|...:..||:
  Rat   382 LPDGTHLQPGTKFIKHWRMKNTGNV-----KWSADTKLKFMWGNLTLASTEKKDVLVPCLKAGHI 441

  Fly   648 NVVKTLLTLGCHPSLQDSEGDTPLHDAISKEHDEM-----LSLLLDFGADITLNNNNGFNALHHA 707
            .||......   |:|   ||...||..:|.:..:.     .|:::|
  Rat   442 GVVSVEFIA---PTL---EGTYTLHWRLSHKGQQFGPRVWCSIIVD------------------- 481

  Fly   708 ALKGNPSAMKILLTKTNRPWIVEEKKDDGYTALHLAALNNHVEIAELLVHMGKANMDRQNVNL-- 770
            ....:.|.:.:     .|..|...|.||.......|.|     :||..:.:|:.....:....
  Rat   482 PFPSSESPVNL-----ERDGISSSKADDFTCEQEEAFL-----LAEEEIPLGEVTKQTEGTGSSA 536

  Fly   771 -QTALHLAVERQ-HVQIVKLLVQDG------ADLNIPDK----DGDTPLHEALRHHTLSQLKQLQ 823
             |...|.|.||: ::..|.||....      .|:||..:    ..:||:....|...|.....|.
  Rat   537 PQKTQHAASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDVTPRMSPLPHDSPLI 601

  Fly   824 DVEGFGKLLMGLRNANNKKASASIACFLAANGADLTLKNRKQQTPL-------DLCPDPNLCKTL 881
            :..|.|::           ...|....|.|:.....|..||.:||.       ||.....:|:|:
  Rat   602 EKPGLGRI-----------QEESEGAGLKASPDSTVLTKRKAETPASVEETEEDLSGTQFVCETV 655

  Fly   882 VKCYNERKTDDSELPGNVAGTSSSARARAASGSLN-QSSSVNMPLSSLAASSTFPAASSSSIFAL 945
            ::........|...|         .|.|:....|. .|:....||    ....|....||..|||
  Rat   656 IRSLTLDAAPDHNPP---------CRQRSPQRELQLYSTEEQQPL----MLPGFCRKDSSLKFAL 707

  Fly   946 -----NGIANEMSQSLH---------------EDPPKSSASLDECLV----CSDAKR---DTVFK 983
                 :|  :|..:.:|               |...:||||.::.::    |.|..|   |:::.
  Rat   708 PEEGPHG--DEREEIVHIAEEEAIEEEDVQDEEVQSQSSASSEDYIIILPECFDTSRPLGDSMYS 770

  Fly   984 PC--------------GHVSCCETCAPRVKKCLICRETVSSREKIDECLVCSDRRAAVFFRPCGH 1034
            ..              |..|..|....|.:  |..||:....:.|.:.|..|.....|   |...
  Rat   771 SALSQPGLERGAEGEPGIESGQEPAEARER--LPERESQPKEQSISDILTTSQHLDTV---PLVP 830

  Fly  1035 MVACEHCSALMKKCVLCRTQIDEILSFSLCCGGSGRPEKVSVAAGAMATVGLPLPDDRFMEAAAA 1099
            .||                .:...||.|..||....|.   |.:.......||:||....|...:
  Rat   831 EVA----------------GLPAALSRSAPCGQYEAPR---VDSPVTIQEVLPVPDHVRGEPRGS 876

  Fly  1100 AACANA-----------SGHSVA 1111
            ...||:           :|.|:|
  Rat   877 TGLANSRQKSCDHSRHHNGSSIA 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib1	NP_648826.2	MIB_HERC2	109..165	CDD:284184
		ZZ_Mind_bomb	177..221	CDD:239079
		MIB_HERC2	248..312	CDD:284184
		Ank_4	568..620	CDD:290365	11/58 (19%)
		ANK repeat	568..598	CDD:293786	7/32 (22%)
		ANK repeat	600..631	CDD:293786	7/39 (18%)
		Ank_2	606..697	CDD:289560	20/104 (19%)
		ANK	628..756	CDD:238125	24/132 (18%)
		ANK repeat	633..664	CDD:293786	7/30 (23%)
		ANK repeat	666..695	CDD:293786	7/33 (21%)
		ANK repeat	699..733	CDD:293786	3/33 (9%)
		Ank_2	704..800	CDD:289560	22/105 (21%)
		ANK	734..872	CDD:238125	34/158 (22%)
		ANK repeat	735..767	CDD:293786	6/31 (19%)
		ANK repeat	769..800	CDD:293786	11/40 (28%)
		Ank_2	774..862	CDD:289560	21/98 (21%)
		ANK repeat	802..862	CDD:293786	11/59 (19%)
		zf-C3HC4_3	968..1011	CDD:290631	11/63 (17%)
		zf-C3HC4_3	1013..1058	CDD:290631	7/44 (16%)
		zf-C3HC4_3	1179..1222	CDD:290631
Nbr1	NP_001019936.1	PB1_NBR1	5..86	CDD:99718
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..149
		ZZ_NBR1_like	217..261	CDD:239080
		NBR1_like	371..481	CDD:271343	24/120 (20%)
		ATG8 family proteins-binding. /evidence=ECO:0000250	544..638		24/104 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..645		8/33 (24%)
		ATG8 family proteins-binding. /evidence=ECO:0000250	745..756		2/10 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..813		7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	867..895		4/27 (15%)
		UBA_NBR1	933..971	CDD:270504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900