DRSC/TRiP Functional Genomics Resources

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Protein Alignment mib1 and Mib1

DIOPT Version :10

Sequence 1:NP_648826.2 Gene:mib1 / 39750 FlyBaseID:FBgn0263601 Length:1226 Species:Drosophila melanogaster
Sequence 2:NP_659109.2 Gene:Mib1 / 225164 MGIID:2443157 Length:1006 Species:Mus musculus


Alignment Length:1147 Identity:708/1147 - (61%)
Similarity:828/1147 - (72%) Gaps:170/1147 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 RFSMEGVGARVIRGPDWKWNKQDGGEGHVGTVRNFESAEEVVVVWDNGTAANYRCAGAYDLRILD 166
            |..:|||||||:|||||||.|||||||||||||:|||.|||||||||||||||||:|||||||||
Mouse     8 RVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILD 72

  Fly   167 SAPTGVKHEGTMCDTCRQQPIFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRITTPGGERTML 231
            |||||:||:||||||||||||.|||||||||.|||||::||||||||||||||||||||.||.:|
Mouse    73 SAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLL 137

  Fly   232 EPRRKSKKVLARGIFPGARVVRGVDWQWEDQDGGVGRRGKVNEIQDWSSASPRSAAYVIWDNGSK 296
            |.||||||:.|||||.||||||||||||||||||.||||||.||||||::||.|||||:||||:|
Mouse   138 ESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAK 202

  Fly   297 NLYRVGFEGMADLKVVNDAKGSNVYRDHLPLLGENGPGKGPHGFQIGDKVTVDLDLEIVQSLQHG 361
            ||||||||||:|||.|.||||.:.||||.|:|||....:.|.|.||||.|.:|||||||||||||
Mouse   203 NLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHG 267

  Fly   362 HGGWTDGMFECLSNAGMVVGIDEDHDIVVAYNSGNRWTFNPAVLTK---VSSPTTA------PPE 417
            ||||||||||.|:..|.|.||||||||||.|.||||||||||||||   |.|...|      ..:
Mouse   268 HGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQ 332

  Fly   418 FQVGDIVKICSDVESIKILQRGHGEWADAMQLTLGKIGRVQQVYHDNDLKVEVGNTSWTYNPLAV 482
            |||||:|::|.|:|.||:|||||||||:||..||||:|||||:|.|:||||||..|||||||.||
Mouse   333 FQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAV 397

  Fly   483 CKVASSTASDGSCAPVIPSSERLSAILKKLFEPNVSGDATEEFVKAAANGFAARCEEYLAGAAQP 547
            .|||.:.::..:.     |.||||.:||||||...|||..||.|||||||..|:.|:.|      
Mouse   398 SKVAPAGSAISNA-----SGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLL------ 451

  Fly   548 STSSASPSSGPDVNVNGVFAGHTALQAASQNGHIEVIQVLLRHAVDVEIEDKDGDRAVHHAAFGD 612
                    ..|||:|||..|||||:||||||||::::::||:..||||.||||||||||||||||
Mouse   452 --------KRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGD 508

  Fly   613 EAAVIEILAKAGADLNARNKRRQTSLHIAVNKGHLNVVKTLLTLGCHPSLQDSEGDTPLHDAISK 677
            |.||||:|.:..||||||||||||.||||||||||.||||||..|||||||||||||||||||||
Mouse   509 EGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISK 573

  Fly   678 EHDEMLSLLLDFGADITLNNNNGFNALHHAALKGNPSAMKILLTKTNRPWIVEEKKDDGYTALHL 742
            :.|::|::||:.|||:|:.|||||||||||||:||||||::||:|..|||||:||||||||||||
Mouse   574 KRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHL 638

  Fly   743 AALNNHVEIAELLVHMGKANMDRQNVNLQTALHLAVERQHVQIVKLLVQDGADLNIPDKDGDTPL 807
            ||||||||:||||||.|.||:|.||||.||||||||||||.|||:|||:.||.|:|.||||||||
Mouse   639 AALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL 703

  Fly   808 HEALRHHTLSQLKQLQDVEGFGK-----------LLMGL-RNANNKKASASIACFLAANGADLTL 860
            ||||||||||||:||||::..||           |:||| .....||::||||||||||||||::
Mouse   704 HEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSI 768

  Fly   861 KNRKQQTPLDLCPDPNLCKTLVKCYNERKTDDSELPGNVAGTSSSARARAASGSLNQSSSVNMPL 925
            :|:|.|:||||||||:|||.|.||:.|:      :.|.|...|.|.                   
Mouse   769 RNKKGQSPLDLCPDPSLCKALAKCHKEK------VSGQVGSRSPSM------------------- 808

  Fly   926 SSLAASSTFPAASSSSIFALNGIANEMSQSLHEDPPKSSASLDECLVCSDAKRDTVFKPCGHVSC 990
                                  |:|:            |.:|:||:||||.||||:|.||||::.
Mouse   809 ----------------------ISND------------SETLEECMVCSDMKRDTLFGPCGHIAT 839

  Fly   991 CETCAPRVKKCLICRETVSSREKIDECLVCSDRRAAVFFRPCGHMVACEHCSALMKKCVLCRTQI 1055
            |..|:|||||||||:|.|.||.||:||:||||::|||.|:|||||.|||:|::||||||.||..:
Mouse   840 CSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCRAVV 904

  Fly  1056 DEILSFSLCCGGSGRPEKVSVAAGAMATVGLPLPDDRFMEAAAAAACANASGHSVAMNNTVVTPV 1120
            :..:.|..||||.                                                    
Mouse   905 ERRVPFITCCGGK---------------------------------------------------- 917

  Fly  1121 AGSSNQLNSQNNLLAAAAASSNVSNLSAAGNAMVAPSNVNNFQMD-DVQKLKQQLQDIKEQTMCP 1184
                              :|.:.|:..::||..|...:.:|..:: |||||:|||||||||||||
Mouse   918 ------------------SSEDPSDEISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCP 964

  Fly  1185 VCFDRIKNMVFLCGHGTCQMCGDQIEGCPICRKTVEKRILLF 1226
            ||.||:|||:|||||||||:|||::..||||||.:|:||||:
Mouse   965 VCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY 1006

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mib1NP_648826.2 MIB_HERC2 109..166 CDD:461991 51/56 (91%)
ZZ_Mind_bomb 177..221 CDD:239079 39/43 (91%)
MIB_HERC2 248..313 CDD:461991 55/64 (86%)
SH3_15 340..405 CDD:465720 52/64 (81%)
SH3_15 418..482 CDD:465720 46/63 (73%)
ANKYR 559..824 CDD:440430 208/264 (79%)
ANK repeat 568..598 CDD:293786 18/29 (62%)
ANK repeat 600..631 CDD:293786 24/30 (80%)
ANK repeat 633..664 CDD:293786 26/30 (87%)
ANK repeat 666..695 CDD:293786 19/28 (68%)
ANK repeat 699..733 CDD:293786 26/33 (79%)
ANK repeat 735..767 CDD:293786 26/31 (84%)
ANK repeat 769..800 CDD:293786 23/30 (77%)
ANK repeat 802..862 CDD:293786 44/71 (62%)
RING-HC_MIB1_rpt1 968..1005 CDD:438384 25/36 (69%)
RING-HC_MIB1_rpt2 1015..1052 CDD:438385 25/36 (69%)
RING-HC_MIB1_rpt3 1181..1226 CDD:438387 33/44 (75%)
Mib1NP_659109.2 MIB_HERC2 15..72 CDD:461991 51/56 (91%)
ZZ_Mind_bomb 83..127 CDD:239079 39/43 (91%)
MIB_HERC2 154..218 CDD:461991 55/63 (87%)
SH3_15 246..311 CDD:465720 52/64 (81%)
SH3_15 333..397 CDD:465720 46/63 (73%)
ANK 1 430..460 17/43 (40%)
ANKYR 444..720 CDD:440430 212/289 (73%)
ANK 2 463..492 18/28 (64%)
ANK repeat 464..494 CDD:293786 18/29 (62%)
ANK repeat 496..560 CDD:293786 53/63 (84%)
ANK 3 496..525 22/28 (79%)
ANK 4 529..558 24/28 (86%)
ANK repeat 562..593 CDD:293786 20/30 (67%)
ANK 5 562..591 19/28 (68%)
ANK 6 595..627 25/31 (81%)
ANK repeat 631..663 CDD:293786 26/31 (84%)
ANK 7 631..661 25/29 (86%)
ANK repeat 665..696 CDD:293786 23/30 (77%)
ANK 8 665..694 22/28 (79%)
PHA03095 668..>778 CDD:222980 71/109 (65%)
ANK 9 698..729 24/30 (80%)
RING-HC_MIB1_rpt1 817..854 CDD:438384 25/36 (69%)
RING-HC_MIB1_rpt2 864..901 CDD:438385 25/36 (69%)
RING-HC_MIB1_rpt3 961..1006 CDD:438387 33/44 (75%)

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