DRSC/TRiP Functional Genomics Resources

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Protein Alignment mib1 and Sqstm1

DIOPT Version :9

Sequence 1:NP_648826.2 Gene:mib1 / 39750 FlyBaseID:FBgn0263601 Length:1226 Species:Drosophila melanogaster
Sequence 2:NP_035148.1 Gene:Sqstm1 / 18412 MGIID:107931 Length:442 Species:Mus musculus


Alignment Length:528 Identity:109/528 - (20%)
Similarity:168/528 - (31%) Gaps:184/528 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 GGNSAAALVRRFSM-----EGVGARVIRGPD------------WKWNKQDGGEGHV----GTVRN 135
            |...|...:||||.     ....|:...||.            :...:..|.:.|.    |.:..
Mouse    12 GKEEATREIRRFSFCFSPEPEAEAQAAAGPGPCERLLSRVAVLFPTLRPGGFQAHYRDEDGDLVA 76

  Fly   136 FESAEEVVVVWDNGTAANY--------------RCAGAYDLRILDSAPTGVKHEGTMCDTCRQQP 186
            |.|.||:.:      |.:|              .|...:.......||..:.|...:||.| ..|
Mouse    77 FSSDEELTM------AMSYVKDDIFRIYIKEKKECRREHRPPCAQEAPRNMVHPNVICDGC-NGP 134

  Fly   187 IFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRITTPGGERTMLEPRRKSKKVLARGIF--PGA 249
            :.|.|:||:.|.:|||||:| .|...|..|.......|.|..:......:..:.|..|.|  || 
Mouse   135 VVGTRYKCSVCPDYDLCSVC-EGKGLHREHSKLIFPNPFGHLSDSFSHSRWLRKLKHGHFGWPG- 197

  Fly   250 RVVRGVDWQWEDQDGGVGRRGKVNEIQDWSSASPRSAAYVIWDNGSKNLYRVGFEGMADLKVVND 314
                     ||     :|..|      :||...||:                     .|.:....
Mouse   198 ---------WE-----MGPPG------NWSPRPPRA---------------------GDGRPCPT 221

  Fly   315 AKGSNVYRDHLPLLGENGPGKGPH-GF--QIGDKVTVDLDLEIVQSLQHGHGGWTDGMFECLSNA 376
            |:.:            :.|.:.|: .|  .:|:.|..                       .||..
Mouse   222 AESA------------SAPPEDPNVNFLKNVGESVAA-----------------------ALSPL 251

  Fly   377 GMVVGIDEDHDIVVAYNSGNRWTFNPAVLTKVSSPTTAPPEFQVGDIVKICSDVESIKILQRGHG 441
            |:.|.||.:|       .|.|....|......|:.|......|...    ||...|   ...|.|
Mouse   252 GIEVDIDVEH-------GGKRSRLTPTTPESSSTGTEDKSNTQPSS----CSSEVS---KPDGAG 302

  Fly   442 EWADAMQLT-------LGKIGRVQQVYHDNDLKVEVGNTS-----WTYNPLAVCKVASSTA---- 490
            | ..|..||       |..:|:.::       ::|.||.|     ||:  |:..:|..||.    
Mouse   303 E-GPAQSLTEQMKKIALESVGQPEE-------QMESGNCSGGDDDWTH--LSSKEVDPSTGELQS 357

  Fly   491 -----SDGSCAPVIPSSERLSAILKKLFEPNVSGDATEEFVKAAAN----GFA---------ARC 537
                 |:|. :.:.||.|..:.:.:....|::..:|....:::.:.    ||:         .:.
Mouse   358 LQMPESEGP-SSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQT 421

  Fly   538 EEYLAGAA 545
            :.|..|||
Mouse   422 KNYDIGAA 429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mib1NP_648826.2 MIB_HERC2 109..165 CDD:284184 13/85 (15%)
ZZ_Mind_bomb 177..221 CDD:239079 18/43 (42%)
MIB_HERC2 248..312 CDD:284184 10/63 (16%)
Ank_4 568..620 CDD:290365
ANK repeat 568..598 CDD:293786
ANK repeat 600..631 CDD:293786
Ank_2 606..697 CDD:289560
ANK 628..756 CDD:238125
ANK repeat 633..664 CDD:293786
ANK repeat 666..695 CDD:293786
ANK repeat 699..733 CDD:293786
Ank_2 704..800 CDD:289560
ANK 734..872 CDD:238125
ANK repeat 735..767 CDD:293786
ANK repeat 769..800 CDD:293786
Ank_2 774..862 CDD:289560
ANK repeat 802..862 CDD:293786
zf-C3HC4_3 968..1011 CDD:290631
zf-C3HC4_3 1013..1058 CDD:290631
zf-C3HC4_3 1179..1222 CDD:290631
Sqstm1NP_035148.1 Interaction with LCK. /evidence=ECO:0000250|UniProtKB:Q13501 2..50 9/37 (24%)
PB1_p62 5..102 CDD:99723 18/95 (19%)
Interaction with PRKCZ and dimerization. /evidence=ECO:0000250|UniProtKB:O08623 43..107 10/69 (14%)
Interaction with PAWR. /evidence=ECO:0000250|UniProtKB:Q13501 50..80 4/29 (14%)
Interaction with GABRR3. /evidence=ECO:0000250|UniProtKB:O08623 122..224 36/145 (25%)
ZZ_NBR1_like 126..166 CDD:239080 18/41 (44%)
LIM protein-binding. /evidence=ECO:0000250|UniProtKB:Q13501 170..220 16/91 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..234 9/68 (13%)
TRAF6-binding. /evidence=ECO:0000250|UniProtKB:Q13501 228..233 1/4 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..308 13/53 (25%)
Interaction with NTRK1. /evidence=ECO:0000250|UniProtKB:O08623 269..442 38/179 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 321..386 16/74 (22%)
MAP1LC3B-binding. /evidence=ECO:0000250|UniProtKB:Q13501 323..344 6/29 (21%)
LIR 338..343 2/6 (33%)
Interaction with KEAP1. /evidence=ECO:0000269|PubMed:20173742, ECO:0000269|PubMed:20421418 349..354 2/4 (50%)
UBA_5 381..442 CDD:318725 8/49 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4582
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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