DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mib1 and mib2

DIOPT Version :9

Sequence 1:	NP_648826.2	Gene:	mib1 / 39750	FlyBaseID:	FBgn0263601	Length:	1226	Species:	Drosophila melanogaster
Sequence 2:	NP_001116916.1	Gene:	mib2 / 100144683	XenbaseID:	XB-GENE-1217510	Length:	951	Species:	Xenopus tropicalis

Alignment Length:	1162	Identity:	400/1162 - (34%)
Similarity:	568/1162 - (48%)	Gaps:	245/1162 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 NSAAALVRRFSMEGVGARVIRGPDWKWNKQDGGEGHVGTVRNF-------ESAEEVVVVWDNGTA 151
            ||||       |: ||.||:||.||||:.||.|||.:|||...       ...:.|||.||:||.
Frog     5 NSAA-------MQ-VGMRVVRGIDWKWSNQDNGEGSMGTVVEIGRQGSPTTPDKTVVVQWDHGTR 61

  Fly   152 ANYRCA--GAYDLRILDSAPTGVKHEGTMCDTCRQQPIFGIRWKCAECINYDLCSICYHGDKHHL 214
            .|||..  |||||.:.|:|.|||:|...:||.|::..|.|:||||..|.:||||:.||..:||.|
Frog    62 TNYRTGFQGAYDLLLYDNAQTGVRHPNIICDCCKKHGIRGMRWKCKVCFDYDLCTQCYMNNKHDL 126

  Fly   215 RHRFYRITTPGGERTMLEPRRKSKKVLARGIFPGARVVRGVDWQWEDQDGGVGRRGKVNEIQDWS 279
            .|.|.|..|......:|..|:...:|:.:|||.||:||||.||:|.:||||.|:.|:|.:|:.|.
Frog   127 SHIFERYETADSRPVILSTRQGLPRVVLKGIFQGAKVVRGPDWEWGNQDGGEGKVGRVVDIRGWD 191

  Fly   280 SASPRSAAYVIWDNGSKNLYRVGFEGMADLKVVNDAKGSNVYRDHLPLLG-----ENGPGKGPHG 339
            ..:.||.|.|.|.:|:.|:||||.:|..|||.:.||.|.:.||||||.||     :.......|.
Frog   192 VETGRSVASVTWADGTTNVYRVGHKGKVDLKCITDAPGGHYYRDHLPKLGKPAELQRKESSERHP 256

  Fly   340 FQIGDKVTVDLDLEIVQSLQHGHGGWTDGMFECLSNAGMVVGIDEDHDIVVAYNSGNRWTFNPAV 404
            ||.||||...||:||::.:|.|||||...|.|.:...|.|..|.|..|:.|.|||..||||:|..
Frog   257 FQHGDKVKCLLDVEILREMQEGHGGWNPKMAEFIGQTGTVHRITERGDVRVQYNSETRWTFHPGA 321

  Fly   405 LTKVSSPTTAPPEFQVGDIVKICSDVESIKILQRGHGEWADAMQLTLGKIGRVQQVYHDNDLKVE 469
            |||.:|       |.|||:|::..:::::|.||.|||||.|.|...||:||:|.:|:.|.|::|.
Frog   322 LTKQNS-------FWVGDVVRVMDNMDAVKKLQVGHGEWTDDMVSALGQIGKVIKVFGDGDMRVS 379

  Fly   470 VGNTSWTYNPLAVCKVASSTASDGSCAPVIPSSE---RLSAILKKLFEPNVSGDATEEFVKAAAN 531
            ||..|||:||  .|..:.....|.:......:.|   .|.:||:||.......::....|..||.
Frog   380 VGGQSWTFNP--ACLTSYQREEDANLMTTENAKESKNTLVSILEKLLSQKTDCESPTSLVIEAAQ 442

  Fly   532 GFAARCEEYLAGAAQPSTSSASPSSGPD-VNVNGVFAGHTALQAASQNGHIEVIQVLLRHAVDVE 595
            |..|:..|.|             ...|| |::..  .|.||||.||..|::||::|||:...:::
Frog   443 GNTAKVREML-------------QKYPDKVDIKN--QGRTALQVASHLGYMEVVKVLLQANANID 492

  Fly   596 IEDKDGDRAVHHAAFGDEAAVIEILAKAGADLNARNKRRQTSLHIAVNKGHLNVVKTLLTLGCHP 660
            :.|.:||.|:|:||:|::|.|:.:|...||:....|..:.|:|:||||||...||:.|....|..
Frog   493 LRDDEGDTALHYAAYGNQAGVVRVLLSKGANAELLNNAKCTALYIAVNKGFTEVVQVLCNPNCAI 557

  Fly   661 SLQDSEGDTPLHDAISKEHDEMLSLLLDF-GADITLNNNNGFNALHHAALKGNPSAMKILLTKTN 724
            ::|||.||||||.||:.:...::.:|.:. ..|.|:.||.|||.|||:|||||..|:..:|.:..
Frog   558 NMQDSFGDTPLHYAITADFRSIIEILTEVPNIDFTVQNNQGFNLLHHSALKGNVLAVSKILERAR 622

  Fly   725 RPWIVEEKKDDGYTALHLAALNNHVEIAELLVHMGKANMDRQNVNLQTALHLAVERQHVQIVKLL 789
            :  :|:.||:||:||||||.||||.|:.|:|:..|:.:::.:|...||.|||||.:.|:.:|.||
Frog   623 Q--LVDSKKEDGFTALHLATLNNHQEVVEILIKEGRCDVNLRNNRNQTPLHLAVAQGHISLVHLL 685

  Fly   790 VQDGADLNIPDKDGDTPLHEALRHHTLSQLKQLQDVEGFGKLLM------GLRNANNKKASASIA 848
            |.:|||:|..|:|||||:|.......|..:...|  ||.|..|:      ||.........:::|
Frog   686 VTEGADVNAEDEDGDTPMHIVFVRQHLKSIDSQQ--EGNGSSLLTKLEASGLPGNIELNVGSAMA 748

  Fly   849 CFLAANGADLTLKNRKQQTPLDLCPDPNLCKTLVKCYNERKTDDSELPGNVAGTSSSARARAASG 913
            ||||.:|||:...|.:.::||||..|..:.. |||.:.::..:..||
Frog   749 CFLALSGADINYANHRGKSPLDLIADGRITH-LVKNFAQKFREQVEL------------------ 794

  Fly   914 SLNQSSSVNMPLSSLAASSTFPAASSSSIFALNGIANEMSQSLHEDPPKSSASLDECLVCSDAKR 978
                                                         |.|..|        ||..:.
Frog   795 ---------------------------------------------DSPTVS--------CSLRRV 806

  Fly   979 DTVFKPCGHVSCCETCAPRVKKCLICRETVSSREKIDECLVCSDRRAAVFFRPCGHMVACEHCSA 1043
            .|......::|.|...:|.                  ||||||:....|.|.||.|.:.||.||.
Frog   807 HTTPNTMTNLSPCSAASPA------------------ECLVCSELAVLVSFFPCQHSIVCEECSR 853

  Fly  1044 LMKKCVLCRTQIDEILSFSLCCGGSGRPEKVSVAAGAMATVGLPLPDDRFMEAAAAAACANASGH 1108
            .||||:.|:          :|.....|.:...|..
Frog   854 RMKKCIKCQ----------VCIARKLRQDSTEVEC------------------------------ 878

  Fly  1109 SVAMNNTVVTPVAGSSNQLNSQNNLLAAAAASSNVSNLSAAGNAMVAPSNVNNFQMDDVQKLKQQ 1173
                                                          :||    .::.|.:|:.::
Frog   879 ----------------------------------------------SPS----LEVSDQKKVMEE 893

  Fly  1174 LQD----IKEQTMCPVCFDRIKNMVFLCGHGTCQMCGDQIEGCPICRKTVEKRILLF 1226
            ||:    ::|:..||:|.|....:||.||||:|..|...:..|||||:.:.:||.:|
Frog   894 LQNRYRQMEERITCPICIDNHIKLVFQCGHGSCTECSTSLTACPICRQLIRERIQIF 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib1	NP_648826.2	MIB_HERC2	109..165	CDD:284184	32/64 (50%)
		ZZ_Mind_bomb	177..221	CDD:239079	21/43 (49%)
		MIB_HERC2	248..312	CDD:284184	33/63 (52%)
		Ank_4	568..620	CDD:290365	23/51 (45%)
		ANK repeat	568..598	CDD:293786	13/29 (45%)
		ANK repeat	600..631	CDD:293786	12/30 (40%)
		Ank_2	606..697	CDD:289560	36/91 (40%)
		ANK	628..756	CDD:238125	59/128 (46%)
		ANK repeat	633..664	CDD:293786	12/30 (40%)
		ANK repeat	666..695	CDD:293786	10/29 (34%)
		ANK repeat	699..733	CDD:293786	14/33 (42%)
		Ank_2	704..800	CDD:289560	46/95 (48%)
		ANK	734..872	CDD:238125	60/143 (42%)
		ANK repeat	735..767	CDD:293786	16/31 (52%)
		ANK repeat	769..800	CDD:293786	16/30 (53%)
		Ank_2	774..862	CDD:289560	37/93 (40%)
		ANK repeat	802..862	CDD:293786	22/65 (34%)
		zf-C3HC4_3	968..1011	CDD:290631	6/42 (14%)
		zf-C3HC4_3	1013..1058	CDD:290631	20/44 (45%)
		zf-C3HC4_3	1179..1222	CDD:290631	18/42 (43%)
mib2	NP_001116916.1	MIB_HERC2	12..77	CDD:369043	32/64 (50%)
		ZZ_Mind_bomb	89..133	CDD:239079	21/43 (49%)
		MIB_HERC2	160..224	CDD:369043	33/63 (52%)
		SH3_15	257..322	CDD:375773	32/64 (50%)
		SH3_15	328..392	CDD:375773	31/65 (48%)
		ANK repeat	434..463	CDD:293786	10/41 (24%)
		PHA03095	448..>711	CDD:222980	116/279 (42%)
		ANK repeat	465..495	CDD:293786	13/29 (45%)
		ANK repeat	497..528	CDD:293786	12/30 (40%)
		ANK repeat	530..561	CDD:293786	12/30 (40%)
		ANK repeat	598..629	CDD:293786	14/32 (44%)
		PHA03095	625..>813	CDD:222980	76/261 (29%)
		ANK repeat	631..663	CDD:293786	16/31 (52%)
		ANK repeat	665..696	CDD:293786	16/30 (53%)
		RING1-HC_MIB2	826..862	CDD:319640	19/35 (54%)
		RING-HC finger (C3HC4-type)	827..861	CDD:319640	18/33 (55%)
		RING2-HC_MIB2	906..951	CDD:319642	20/45 (44%)
		RING-HC finger (C3HC4-type)	907..939	CDD:319642	14/31 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119594at33208
OrthoFinder	1	1.000	-	-		FOG0002693
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010