Protein Alignment LHX1 and Awh

DIOPT Version :10

• Sequence 1: NP_005559.2
• Gene: LHX1 / 3975
• HGNCID: 6593
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_001261379.1
• Gene: Awh / 38451
• FlyBaseID: FBgn0013751
• Length: 287
• Species: Drosophila melanogaster
• Alignment Length: 371
• Identity: 113/371 - (30%)
• Similarity: 157/371 - (42%)
• Gaps: 105/371 - (28%)

Human     4 CAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNL--TEKCFSREGKLYCKNDFFRCFGTKCAGC 66
            ||.|..||.|||.|.|...:||..|::||.|.|.|  .:.||.||.::|||.|:.:.||.||:.|
  Fly     8 CAACGEPISDRFFLEVGGCSWHAHCLRCCMCMCPLDRQQSCFIRERQVYCKADYSKNFGAKCSKC 72

Human    67 AQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLH 131
            .:|||.||.|||||..||||.||.|..|.:||||||:..::|: :.:||..||        .::.
  Fly    73 CRGISASDWVRRARELVFHLACFACDQCGRQLSTGEQFALMDD-RVLCKAHYL--------ETVE 128

Human   132 SATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEAGSNENDDQNLGAKRRGPRTTIKAKQLETLK 196
            ..||.||.....|....|                             |.:..|||...:||:.|:
  Fly   129 GGTTSSDEGCDGDGYHKS-----------------------------KTKRVRTTFTEEQLQVLQ 164

Human   197 AAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPL 261
            |.|.....|.....|::|..|||:.||.||||||.|:::::         ..||   ...::|
  Fly   165 ANFQIDSNPDGQDLERIASVTGLSKRVTQVWFQNSRARQKK---------HIHA---GKNKIR-- 215

Human   262 VDRLEPGELIPNGPFSFYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGG 326
                ||    ....|:.:.:.|.       .|.|      .:.||.|:.|        :|:..|
  Fly   216 ----EP----EGSSFARHINLQL-------TYSF------QNNAQNPMHL--------NGSKAG- 250

Human   327 LEHPLPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEV 372
                                 .:|..:|...|.|....:|.|.:||
  Fly   251 ---------------------LYPTHESSMDELSQDSSVHCMPSEV 275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753	25/52 (48%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	29/54 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..187		9/58 (16%)
		Homeodomain	181..237	CDD:459649	23/55 (42%)
		dnaA	<263..>382	CDD:455861	20/110 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..374		16/80 (20%)
Awh	NP_001261379.1	LIM1_AWH	8..61	CDD:188759	25/52 (48%)
		LIM2_AWH	69..123	CDD:188765	29/54 (54%)
		Homeodomain	149..205	CDD:459649	23/55 (42%)