Protein Alignment LHX1 and ap

DIOPT Version :10

• Sequence 1: NP_005559.2
• Gene: LHX1 / 3975
• HGNCID: 6593
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_724428.1
• Gene: ap / 35509
• FlyBaseID: FBgn0267978
• Length: 469
• Species: Drosophila melanogaster
• Alignment Length: 288
• Identity: 103/288 - (35%)
• Similarity: 148/288 - (51%)
• Gaps: 63/288 - (21%)

Human     4 CAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEK--CFSREGKLYCKNDFFRCFGT-KCAG 65
            |:||.|.|.|||.|:.:::.||..|:||..|:..|..:  |:||:|.:|||||::..||| :|:.
  Fly   148 CSGCGRQIQDRFYLSAVEKRWHASCLQCYACRQPLERESSCYSRDGNIYCKNDYYSFFGTRRCSR 212

Human    66 CAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSL 130
            |...||.::||.|||:.|||:|||.|.:|:..|:.|::..|||. ...|:..|    |:|:|...
  Fly   213 CLASISSNELVMRARNLVFHVNCFCCTVCHTPLTKGDQYGIIDA-LIYCRTHY----SIAREGDT 272

Human   131 ----------HSATTGS--DPSLSPDSQDPSQD------------------------------DA 153
                      :||..||  :.|.||.| |||:.                              ..
  Fly   273 ASSSMSATYPYSAQFGSPHNDSSSPHS-DPSRSIVPTGIFVPASHVINGLPQPARQKGRPRKRKP 336

Human   154 KDSE--SANVS------DKEAGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIR 210
            ||.|  :||:.      |...||:.:.    .::.:..||:.|..||.|:|:.||....|.....
  Fly   337 KDIEAFTANIDLNTEYVDFGRGSHLSS----SSRTKRMRTSFKHHQLRTMKSYFAINHNPDAKDL 397

Human   211 EQLAQETGLNMRVIQVWFQNRRSKERRM 238
            :||:|:|||..||:||||||.|:|.|||
  Fly   398 KQLSQKTGLPKRVLQVWFQNARAKWRRM 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753	24/52 (46%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	23/54 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..187		21/108 (19%)
		Homeodomain	181..237	CDD:459649	26/55 (47%)
		dnaA	<263..>382	CDD:455861
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..374
ap	NP_724428.1	LIM1_Lhx2_Lhx9	148..201	CDD:188755	24/52 (46%)
		LIM2_Lhx2_Lhx9	206..264	CDD:188763	25/58 (43%)
		Homeodomain	368..424	CDD:459649	26/55 (47%)