Protein Alignment LHX1 and Lim3

DIOPT Version :10

• Sequence 1: NP_005559.2
• Gene: LHX1 / 3975
• HGNCID: 6593
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_001260559.1
• Gene: Lim3 / 35184
• FlyBaseID: FBgn0002023
• Length: 555
• Species: Drosophila melanogaster
• Alignment Length: 435
• Identity: 155/435 - (35%)
• Similarity: 208/435 - (47%)
• Gaps: 106/435 - (24%)

Human     4 CAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQ 68
            |.||...|||||:|.||:|.||.||:||.||...|.:|||:|.|:|:||.|||:.:||||:.|..
  Fly   122 CGGCHELILDRFILKVLERTWHAKCLQCSECHGQLNDKCFARNGQLFCKEDFFKRYGTKCSACDM 186

Human    69 GISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSA 133
            ||.|:.:||||:..|:||.||.|.||::.|:||:|.|::::.|.:||.||    ..||...|:.
  Fly   187 GIPPTQVVRRAQDNVYHLQCFLCAMCSRTLNTGDEFYLMEDRKLICKRDY----EEAKAKGLYL- 246

Human   134 TTGSDPSLSPDSQDPSQDDAKDSESANVSDKEAGSNENDDQNLGAKRRGPRTTIKAKQLETLKAA 198
                                            .||.:.|..|   ||  |||||.||||||||.|
  Fly   247 --------------------------------DGSLDGDQPN---KR--PRTTITAKQLETLKTA 274

Human   199 FAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPR-RMRPLV 262
            :..:|||.||:||||:|:|||:|||:||||||||:||:|:|: .|...|...:|||.: ...|..
  Fly   275 YNNSPKPARHVREQLSQDTGLDMRVVQVWFQNRRAKEKRLKK-DAGRTRWSQYFRSMKGNCSPRT 338

Human   263 DR-LEPGEL-----------IPN--------------GPFSFYGDYQSEYYGPGGNYDFFPQGPP 301
            |: |:..||           :.|              .|.|..|.|......|.       |.||
  Fly   339 DKFLDKDELKVDYDSFSHHDLSNDSYSTVNLGLDEGASPHSIRGSYMHGSSSPS-------QYPP 396

Human   302 SSQAQTPVDLPFVPSSGPSG-------TPLGGLEHPLPGHHPSSEAQRFTDILAHPPGDSPSPEP 359
            ||::..||.......|.|..       ..:|...|....||....:...:|:     .:..||:.
  Fly   397 SSRSPPPVGQGHTFGSYPDNIVYTNIDQAVGSSLHASKAHHRLHSSNNVSDL-----SNDSSPDQ 456

Human   360 SLPGPLHSMSAEVFGPSP--------PFSSLSVNGGASYGNHLSH 396
            ..|.         |.|||        ..::.|.|..|:..:..||
  Fly   457 GYPD---------FPPSPDSWLGDSGSTNTTSANNNANNNSSSSH 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753	29/50 (58%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	25/54 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..187		10/58 (17%)
		Homeodomain	181..237	CDD:459649	40/55 (73%)
		dnaA	<263..>382	CDD:455861	31/159 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..374		17/87 (20%)
Lim3	NP_001260559.1	LIM1_Lhx3_Lhx4	122..173	CDD:188754	29/50 (58%)
		LIM2_Lhx3_Lhx4	181..236	CDD:188762	25/54 (46%)
		Homeodomain	257..313	CDD:459649	42/57 (74%)