Protein Alignment LHX1 and Lim1

DIOPT Version :10

• Sequence 1: NP_005559.2
• Gene: LHX1 / 3975
• HGNCID: 6593
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_572505.1
• Gene: Lim1 / 31813
• FlyBaseID: FBgn0026411
• Length: 505
• Species: Drosophila melanogaster
• Alignment Length: 449
• Identity: 202/449 - (44%)
• Similarity: 246/449 - (54%)
• Gaps: 104/449 - (23%)

Human     4 CAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQ 68
            ||||.:||||:||||||:||||..||:||||...||:||||||.||||:|||||.:||||:||.|
  Fly    27 CAGCNKPILDKFLLNVLERAWHASCVRCCECLQPLTDKCFSRESKLYCRNDFFRRYGTKCSGCGQ 91

Human    69 GISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDY-LSNSSVAKENSLHS 132
            ||:||||||:.|.||||||||||.:|.|||||||:||::|:|||:||:|| |..:.....|||..
  Fly    92 GIAPSDLVRKPRDKVFHLNCFTCCICRKQLSTGEQLYVLDDNKFICKDDYLLGKAPSCGHNSLSD 156

Human   133 ATTGS--------DP---------------------------------SLSPDSQ---DPSQDDA 153
            :..||        ||                                 |:|.||:   |.|...:
  Fly   157 SLMGSASEDDDDDDPPHLRATALGLGVLGPNGPDSAGGPLGTSDISVQSMSTDSKNTHDDSDQGS 221

Human   154 KDSESANVSDKEAGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETG 218
            .|.:.....|.:|.:...||.| |:|||||||||||||||.||.||..|||||||||||||:|||
  Fly   222 LDGDPDGRGDSQAENKSPDDAN-GSKRRGPRTTIKAKQLEVLKTAFNQTPKPTRHIREQLAKETG 285

Human   219 LNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGP-FSFYGDY 282
            |.||||||||||:|||||||||::::|  |..||...|:||.....|.||.| .:|| |.::...
  Fly   286 LPMRVIQVWFQNKRSKERRMKQITSMG--RPPFFGGARKMRGFPMNLSPGGL-DDGPGFPYFAAD 347

Human   283 QSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLEHPLPGHHPSSEAQRFTDIL 347
            ....:|.||                    ||.|..||.          .||
  Fly   348 AKFEFGYGG--------------------PFHPHDGPY----------FPG-------------- 368

Human   348 AHPPGDSPSPEPSLPGPL-HSMSAEVFGPSPPFSSLSVNGGASYGNHLSHPPEMNEAAV 405
             ||.|..|...|.  ||: ||      ||.|..:...:...|::......||...::||
  Fly   369 -HPGGPMPFNAPG--GPMDHS------GPIPMVNEFGLTPEATFLGQAGGPPMQLQSAV 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753	37/50 (74%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	39/54 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..187		27/102 (26%)
		Homeodomain	181..237	CDD:459649	48/55 (87%)
		dnaA	<263..>382	CDD:455861	29/120 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..374		16/81 (20%)
Lim1	NP_572505.1	LIM1_Lhx1_Lhx5	27..78	CDD:188753	37/50 (74%)
		LIM2_Lhx1_Lhx5	86..141	CDD:188761	39/54 (72%)
		COG5576	185..324	CDD:227863	73/141 (52%)
		Homeodomain	248..304	CDD:459649	48/55 (87%)