DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hzg and CTDP1

DIOPT Version :9

Sequence 1:	NP_001261912.1	Gene:	hzg / 39748	FlyBaseID:	FBgn0036556	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_004706.3	Gene:	CTDP1 / 9150	HGNCID:	2498	Length:	961	Species:	Homo sapiens

Alignment Length:	296	Identity:	67/296 - (22%)
Similarity:	118/296 - (39%)	Gaps:	78/296 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 DQQRYLLPQVRLTDMHRK---CMVIDLDETLVHSSFKPIPNADFIVPVEIDGTVH--------QV 149
            ||||          :||.   .:::|||:||:|::      ......:...|..|        .:
Human   173 DQQR----------LHRNRKLVLMVDLDQTLIHTT------EQHCQQMSNKGIFHFQLGRGEPML 221

  Fly   150 YVLKRPHVDEFLQKMGELYECVLFTASLAKYADPVADLLD-KWNVFRAR-LFRESCV--YYRGNY 210
            :...|||..:||:|:.:|||..:||.....||..:|..|| :..:|..| |.|:.|:  :.:...
Human   222 HTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILSRDECIDPFSKTGN 286

  Fly   211 IKDLNRLGRDLQKIVIVDNSPASYIFHPDNAVPVKS--WFDDVTDCEL----RELIPLFEKLSKV 269
            :::|...|..:  :.|:|:....:.|.| |.:.||.  :|....|...    ||    .:...||
Human   287 LRNLFPCGDSM--VCIIDDREDVWKFAP-NLITVKKYVYFQGTGDMNAPPGSRE----SQTRKKV 344

  Fly   270 D-SVYSVLCNSNQPLNNQTNQQQHPQELQQAP-----NQLHQQLQQQQQQQTISATTVITQATT- 327
            : |..:.:...:.|:.:       |:.:.|||     |.|.:..::      ::.:...|...:
Human   345 NHSRGTEVSEPSPPVRD-------PEGVTQAPGVEPSNGLEKPARE------LNGSEAATPRDSP 396

  Fly   328 -------------LSAPTMLNQQQTSPPSPQSELLQ 350
                         ..|||. :|:....|.||....|
Human   397 RPGKPDERDIWPPAQAPTS-SQELAGAPEPQGSCAQ 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hzg	NP_001261912.1	HIF-SF_euk	112..270	CDD:274055	44/178 (25%)
CTDP1	NP_004706.3	Biotinyl_lipoyl_domains	21..111	CDD:299706
		FCP1_euk	177..323	CDD:131304	40/154 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..589		22/122 (18%)
		BRCT	636..716	CDD:237994
		FCP1_C	716..961	CDD:286402
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..752
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	780..949
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810