DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hzg and CTDSPL2

DIOPT Version :9

Sequence 1:	NP_001261912.1	Gene:	hzg / 39748	FlyBaseID:	FBgn0036556	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_057480.2	Gene:	CTDSPL2 / 51496	HGNCID:	26936	Length:	466	Species:	Homo sapiens

Alignment Length:	182	Identity:	84/182 - (46%)
Similarity:	115/182 - (63%)	Gaps:	3/182 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 PPLPDQQRYLLPQVRLTDMHRK--CMVIDLDETLVHSSFKPIPNADFIVPVEIDGTVHQVYVLKR 154
            |||.::|....|.:.|......  .:|:||||||||.|...:.:|....||.....::||||..|
Human   265 PPLTEEQLNRKPALPLKTRSTPEFSLVLDLDETLVHCSLNELEDAALTFPVLFQDVIYQVYVRLR 329

  Fly   155 PHVDEFLQKMGELYECVLFTASLAKYADPVADLLD-KWNVFRARLFRESCVYYRGNYIKDLNRLG 218
            |...|||::|.::||.:|||||...|||.:.::|| |..:.|.|||||.||..:||||||||.||
Human   330 PFFREFLERMSQMYEIILFTASKKVYADKLLNILDPKKQLVRHRLFREHCVCVQGNYIKDLNILG 394

  Fly   219 RDLQKIVIVDNSPASYIFHPDNAVPVKSWFDDVTDCELRELIPLFEKLSKVD 270
            |||.|.:|:||||.::.:...|.:|::|||.|..|.||.:|||..|||.:::
Human   395 RDLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDNELLKLIPFLEKLVELN 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hzg	NP_001261912.1	HIF-SF_euk	112..270	CDD:274055	78/160 (49%)
CTDSPL2	NP_057480.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..140
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..240
		HIF-SF_euk	287..448	CDD:274055	78/160 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176152at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820