DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and ZDHHC18

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_115659.1	Gene:	ZDHHC18 / 84243	HGNCID:	20712	Length:	388	Species:	Homo sapiens

Alignment Length:	339	Identity:	91/339 - (26%)
Similarity:	145/339 - (42%)	Gaps:	68/339 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 FHTIGKALFDEH--LMALLPLSVYLATKAWFYVTWLMYIDDAVSFTATVCFLISSLLLWV--CFL 394
            |:..|:.:...|  :.| |.|.:.|.|...|:|....|:  |...|..:..:.:.|..:|  |.|
Human    79 FYCGGRLMLAGHGGVFA-LTLLLILTTTGLFFVFDCPYL--ARKLTLAIPIIAAILFFFVMSCLL 140

  Fly   395 KSWKGDPGII-RPTREQRFKTIIELSERGGIGFEP---------------ASFCSGCLVRRPIRS 443
            ::...||||: |.|..:......::...|...:.|               ..:|..|.:.||.|:
Human   141 QTSFTDPGILPRATVCEAAALEKQIDNTGSSTYRPPPRTREVLINGQMVKLKYCFTCKMFRPPRT 205

  Fly   444 KHCSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYVNQCNV----- 503
            .||||||.||.||||||||||||:|.:|:.:|..|:..|..:.|         ::..|.|
Human   206 SHCSVCDNCVERFDHHCPWVGNCVGRRNYRFFYAFILSLSFLTA---------FIFACVVTHLTL 261

  Fly   504 --RFDDFLGAMRAIGNCDAWVGWVMGNALLHMS-WVIL-LTICQTYQVICLGMTTNERMNRGRYR 564
              :..:||..::..      ...|:...:...| |.|| |:...|| ::...:||||.: :|.:.
Human   262 RAQGSNFLSTLKET------PASVLELVICFFSIWSILGLSGFHTY-LVASNLTTNEDI-KGSWS 318

  Fly   565 HFQAKGGH---SPFTRGPIQNLVDFLECSCFGLVQPKRVDWMNYYDYDAQTHQTIEKEPLLSVD- 625
              ..:||.   :|::...|  :.:.....| |.:.|..:|...:...|     |:...|:.|.:
Human   319 --SKRGGEASVNPYSHKSI--ITNCCAVLC-GPLPPSLIDRRGFVQSD-----TVLPSPIRSDEP 373

  Fly   626 -C---PD-GMAGDH 634
             |   || .|.|.|
Human   374 ACRAKPDASMVGGH 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	48/156 (31%)
ZDHHC18	NP_115659.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67
		zf-DHHC	191..314	CDD:279823	47/139 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..388		8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810