DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and ZDHHC14

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_016866796.1	Gene:	ZDHHC14 / 79683	HGNCID:	20341	Length:	506	Species:	Homo sapiens

Alignment Length:	430	Identity:	105/430 - (24%)
Similarity:	164/430 - (38%)	Gaps:	123/430 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 MVDYTHGNTALHWAILARNAT-AISTLVLKSKASLDVPNLRGETPLSMLESQTGAIWIGAKVMDR 270
            ::.|..|.....|.....|:| |..:|.|::::|..  :|.|  ..|...|::|:..:|::
Human    18 IIIYLCGLEIKSWKATVSNSTLADRSLRLRARSSSS--SLVG--IFSDSASKSGSFCVGSR---- 74

  Fly   271 VKEAALTSQQRRSLLSKLRHDKRLRWWSMVACPFTAFYLAGIVFTVNTLYIIKFFLLGCLYSIFH 335
                ||...|              |.||   |                |..|..:|.||
Human    75 ----ALPWGQ--------------RGWS---C----------------LPTISSWLAGC------ 96

  Fly   336 TIGKALFDEHLMALLPLSVYLATKAWFYVTWLMYIDDAVSFTATVC-FLISSLLLWVCFLKSWKG 399
                         ||....|||.|          |..|:...|.:. |.:...||...|     .
Human    97 -------------LLRSCPYLAVK----------ITPAIPAVAGILFFFVMGTLLRTSF-----S 133

  Fly   400 DPGII-RPTREQRFKTIIELSERGGI---GFEP---------------ASFCSGCLVRRPIRSKH 445
            |||:: |.|.::......::....|.   |:.|               ..:|..|.:.||.|:.|
Human   134 DPGVLPRATPDEAADLERQIDIANGTSSGGYRPPPRTKEVIINGQTVKLKYCFTCKIFRPPRASH 198

  Fly   446 CSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYVNQCNVRFDD--F 508
            ||:||.||.||||||||||||:|.:|:.:|..|:..|..:..::.    .:.:....:|...  |
Human   199 CSLCDNCVERFDHHCPWVGNCVGKRNYRFFYMFILSLSFLTVFIF----AFVITHVILRSQQTGF 259

  Fly   509 LGAMRAIGNCDAWVGWVMGNALLHMSWVIL-LTICQTYQVICLGMTTNERMNRGRYRHFQAKGGH 572
            |.|::     |:....:.........|.|: |:...|| :|....||||.: :|.:.:.:.|..:
Human   260 LNALK-----DSPASVLEAVVCFFSVWSIVGLSGFHTY-LISSNQTTNEDI-KGSWSNKRGKENY 317

  Fly   573 SPFTRGPIQNLVDFLECSCFGL---VQPKRVDWMNYYDYD 609
            :|::.|.|     |..| |..|   :.|..:|...|...|
Human   318 NPYSYGNI-----FTNC-CVALCGPISPSLIDRRGYIQPD 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125	6/26 (23%)
		Ank_2	116..209	CDD:289560	0/1 (0%)
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786	0/1 (0%)
		Ank_5	198..251	CDD:290568	11/44 (25%)
		ANK repeat	212..244	CDD:293786	8/32 (25%)
		zf-DHHC	426..559	CDD:279823	45/150 (30%)
ZDHHC14	XP_016866796.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810