DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and Zdhhc4

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_082655.1	Gene:	Zdhhc4 / 72881	MGIID:	1920131	Length:	343	Species:	Mus musculus

Alignment Length:	302	Identity:	78/302 - (25%)
Similarity:	120/302 - (39%)	Gaps:	73/302 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 FYLAGIVFTVNTLYI------IKFFLLG-----------C--------LYSIFHTIGKALFDEHL 346
            ||||.::..|..:.|      :|..:||           |        |:.:|||........||
Mouse     9 FYLAFLLICVVLICIFTKSQRLKAVVLGGAQVCSRVIPQCLQRAVQTLLHQLFHTRHPTFIVLHL 73

  Fly   347 MALLPLSVYLATKAWFYVTWLMYIDDAVSFTATVCFLISSLLL--------WVCFLKSWKGDPGI 403
              ||...||..           |..:...:...:.|.:..|||        .|.|..:...:||.
Mouse    74 --LLQGLVYAE-----------YTCEVFGYCRELEFSLPYLLLPYVLLSVNLVFFTLTCAANPGT 125

  Fly   404 IRPTREQRFKTIIELSERGGIGFEPASFCSGCLVRRPIRSKHCSVCDRCVARFDHHCPWVGNCIG 468
            |....|   ..::::.:...:.|...|.|..|.:|:|.|||||.:|||||.||||||.||.||||
Mouse   126 ITKANE---SFLLQVYKFDDVMFPKNSRCPTCDLRKPARSKHCRLCDRCVHRFDHHCVWVNNCIG 187

  Fly   469 LKNHSYFMGFLWMLLIMCAWMLYGGSKYYVNQCNV------RFDDFLGAMRAIGNCDAWVGWVMG 527
            ..|..||:.:|..|....|.:....:.:.:....|      .:.|.:|..:|:...     :::.
Mouse   188 AWNTRYFLIYLLTLTASAATIATVTAAFLLRLVTVSDLYQETYLDDVGHFQAVDTV-----FLIQ 247

  Fly   528 NALLH-------MSWVILLT------ICQTYQVICLGMTTNE 556
            :..|.       :.:||:|:      :|....:.....||||
Mouse   248 HLFLAFPRIVFLLGFVIVLSMLLAGYLCFALYLAATNQTTNE 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	47/150 (31%)
Zdhhc4	NP_082655.1	DHHC	151..292	CDD:396215	45/144 (31%)
Zdhhc4	NP_082655.1	Di-lysine motif. /evidence=ECO:0000250\|UniProtKB:Q9NPG8	340..343
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810