DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and zdhhc14

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001038652.1	Gene:	zdhhc14 / 569667	ZFINID:	ZDB-GENE-040724-21	Length:	513	Species:	Danio rerio

Alignment Length:	363	Identity:	91/363 - (25%)
Similarity:	145/363 - (39%)	Gaps:	97/363 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 FYVTWLMYIDDAVSFTATVC-FLISSL---------LLWV----CFLKSWKGDPGII-RPTREQR 411
            ||:|.::.:..:..|.|..| ||.|:|         :|:|    ..|::...|||:: |.|.|:.
Zfish    63 FYLTMVLILVTSGLFFAFDCPFLASNLTPAIPAIGGVLFVFVMGMLLRASFSDPGVLPRATPEEA 127

  Fly   412 F---KTIIELSERGGIGFEP---------------ASFCSGCLVRRPIRSKHCSVCDRCVARFDH 458
            .   :.|...:...|.|:.|               ..:|..|.:.||.|:.|||:||.||.||||
Zfish   128 ADIERQIDANNGPSGPGYRPPPRTREVLINGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDH 192

  Fly   459 HCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYVNQCNVRFDDFLGAMR------AIGN 517
            ||||||||:|.:|:.:|..|:..|..:..::.    .:.:...      .|.|:|      ...:
Zfish   193 HCPWVGNCVGRRNYRFFYLFILSLSFLTIFIF----AFVITHV------ILNALRKALALSTAAD 247

  Fly   518 CDAWVGWVMGNALLHMSWVILLTICQTYQVICL-------------------GMTTNERMNRGRY 563
            .:|......|.|.|.:|...||.:.:.  |:|.                   ..||||.: :|.:
Zfish   248 FEAVQKDPTGLAFLVLSKTALLDVLEV--VVCFFSVWSIVGLSGFHTYLISSNQTTNEDI-KGSW 309

  Fly   564 RHFQAKGGHSPFTRGPIQNLVDFLECSCFGL---VQPKRVDWMNYYDYD-----AQTHQTIEKEP 620
            ...:.||.::|::.|      :|:...|..|   :.|..:|...:...|     .||:.|..
Zfish   310 SSKRGKGNYNPYSYG------NFITNCCSALCGPLPPSLIDRRGFIQPDTPQPATQTNGTSA--- 365

  Fly   621 LLSVDCPDGMAGDHQYVXDKTYRDAK-TLQM---PIAH 654
                 ||......|....|:..:..| .||.   |:.|
Zfish   366 -----CPPNQVQSHMCAQDQCIQSTKFVLQAATNPLLH 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	46/172 (27%)
zdhhc14	NP_001038652.1	zf-DHHC	163..306	CDD:279823	45/155 (29%)
zdhhc14	NP_001038652.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..369		6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910