DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and zdhhc4

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_956343.2	Gene:	zdhhc4 / 561817	ZFINID:	ZDB-GENE-030131-9031	Length:	345	Species:	Danio rerio

Alignment Length:	317	Identity:	77/317 - (24%)
Similarity:	118/317 - (37%)	Gaps:	108/317 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 LYSIFHTIGKALFDEHLMALLPLSVYLATKAWFYVTWLMYIDDAVSFTATVC-----FLISSLLL 389
            ::.:||.........||  ||.:.||    ..|......:..|..|.:.::|     ..:.|.|.
Zfish    59 MHRLFHQRNNFFLYLHL--LLEVVVY----GEFTYEVFGFCLDMGSSSLSLCVPYILLALKSCLF 117

  Fly   390 WVCFLKSWKGDPGIIRPTREQRFKTIIELSERGGIGFEPASFCSGCLVRRPIRSKHCSVCDRCVA 454
            ::|..:    |||.:..:.......|.:..|:   .|:....||.|.:.:|.|||||.||:|||.
Zfish   118 YLCCSR----DPGTLTKSNLSAHLKIYQYDEK---LFQQGMKCSTCQLIKPARSKHCRVCNRCVQ 175

  Fly   455 RFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYVNQCNVRFDDFLGAMRAIGNCD 519
            ||||||.||.||||.:|..|||.:   ||.:||                     :....|:...|
Zfish   176 RFDHHCVWVNNCIGAQNTRYFMLY---LLSVCA---------------------MAGNIAVLTTD 216

  Fly   520 AWVGWVMGNALLHMSWV-----------------ILLTICQT---------------------YQ 546
            ..:..|:...|||..::                 :.||..:.                     :.
Zfish   217 MLLQTVLRTGLLHAHYIDEQGIQQPAGPLFIIQHLFLTFPRIVFMLGFLVFVFFLLAGYCLFHFY 281

  Fly   547 VICLGMTTNERMNRGRYRHFQAKG----------GH------SPFT----RGPIQNL 583
            ::.:..|:||        .|:|||          ||      :||.    ||.::|:
Zfish   282 LVLVNQTSNE--------WFKAKGHNCQHCHPYSGHNCRTSYNPFRGFYHRGILKNI 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	46/170 (27%)
zdhhc4	NP_956343.2	DHHC	152..296	CDD:396215	46/175 (26%)
zdhhc4	NP_956343.2	Di-lysine motif. /evidence=ECO:0000250\|UniProtKB:Q9NPG8	342..345
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D445686at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920