DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and zdhhc12

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_012825930.1	Gene:	zdhhc12 / 550061	XenbaseID:	XB-GENE-1216126	Length:	276	Species:	Xenopus tropicalis

Alignment Length:	328	Identity:	85/328 - (25%)
Similarity:	133/328 - (40%)	Gaps:	80/328 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 MVACPFTAFYLAGIVFTVNTLYIIKFFLLGCLYSIFHTIGKALFDEHLMALLPLSVYLATKAWFY 363
            |..|..:|.:|...|.||.|..:              |:...|.|..:..:....:|.....|..
Frog     1 MFRCVLSAGFLVRTVHTVLTWGV--------------TLVLFLHDTDIFFICHSDLYHQENQWKL 51

  Fly   364 VTWLMYIDDAVSFTATVCFLISSLLLWVCFLKSWKGDPG-IIRPTREQRFKTIIELSERGGIGFE 427
            :       ..:||...|  |.|.||.:...|.    ||| ::....::...|.:|....  |...
Frog    52 L-------QPLSFGLLV--LCSVLLYFAVSLM----DPGYVLSDCNKKPLPTYLEQGVM--IPEA 101

  Fly   428 PASF----CSGCLVRRPIRSKHCSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAW 488
            |:..    |..||:::|||::||..|..||.||||||||:.||:|.:||..||.:|.:..::..|
Frog   102 PSGMRLRRCGYCLLQQPIRARHCKTCHHCVRRFDHHCPWIENCVGERNHPLFMLYLGVQFLVLLW 166

  Fly   489 ---MLYGGSKYYVNQCNVRFDDFLGAMRAIGNCDAWVGWVMGNALLHMSWVI---------LLTI 541
               :.:.|.::..                     :|..|:..|..|.:::::         ||..
Frog   167 AFRLTWSGFQFEA---------------------SWTEWLKVNIFLLLAFILTGIFTFVVALLLG 210

  Fly   542 CQTYQVICLGMTTNERMNRGR---YRHFQAKGGHSPFTRGPIQNLVDFLECSCFGLVQPKRVDWM 603
            |..|.:.| .:||.|.|:..|   .:|:.:  ..:||.:|..:||.||. |.|      .||.|.
Frog   211 CHCYLISC-NVTTWEFMSHHRISYLKHYDS--DTNPFDKGIARNLWDFF-CKC------NRVAWE 265

  Fly   604 NYY 606
            ..|
Frog   266 QVY 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	42/148 (28%)
zdhhc12	XP_012825930.1	DHHC	105..228	CDD:366691	42/144 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000