DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hip14 and ZDHHC13

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_061901.2	Gene:	ZDHHC13 / 54503	HGNCID:	18413	Length:	622	Species:	Homo sapiens

Alignment Length:	627	Identity:	233/627 - (37%)
Similarity:	342/627 - (54%)	Gaps:	51/627 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SACQAATTGSCVPGTGQQPDNERQSALIAQQPPTAPVEPDYSGFDIVKATQYGAIARVRELVESG 68
            |.|:..:.|...||.|:......::..:|......|:..|.|..|||||||||...|.:||||:|
Human     8 SQCRNHSHGPHPPGFGRYGICAHENKELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAG 72

  Fly    69 WDVNQPDSETVTLLHWAAINNRRDIIRYFLEKGATVDAVGGELNATPLHWATRQGHLGAVVLLMA 133
            :||.|||.|.|:||||||||||.|::::::.|||.||.:||:||:||||||.|||||..|:||:.
Human    73 YDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQ 137

  Fly   134 AGADPRIRDAEGCSCIHIAAQFAHTALVAYFIAKGVDPDLQDRGGMTALMWAAWKVCALDPVRLL 198
            .||||.:.|.||.|.||:|..|.|..::||.|:||...::.|..|.|.||.:|.||...:|...|
Human   138 HGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFL 202

  Fly   199 LTLGANPAMVDYTHGNTALHWAILARNATAISTLVLKSKASLDVPNLRGETPLSMLESQTGAIWI 263
            |....:..:||..|.||.||||:.|.|..|:..| |::.:|||:.|::|||||.|.......:
Human   203 LKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKL-LEAGSSLDIQNVKGETPLDMALQNKNQL-- 264

  Fly   264 GAKVMDRVKEAALTSQQRRSLLSKLRHDKRLRWWS-MVACPFTAFYLAGIVFTVNTLYIIKF--- 324
               ::..:|..|           |:|.:::.|.|. :..|......:..::......||:.|
Human   265 ---IIHMLKTEA-----------KMRANQKFRLWRWLQKCELFLLLMLSVITMWAIGYILDFNSD 315

  Fly   325 --FLLGC-LYSIFHTIGKALFDEHL-----MALLPLSVYLATKAWFYVTW-LMYIDDAVSFTATV 380
              .|.|| |.::|..  .:||...|     :..||.:..|::..|.::|| :::..|........
Human   316 SWLLKGCLLVTLFFL--TSLFPRFLVGYKNLVYLPTAFLLSSVFWIFMTWFILFFPDLAGAPFYF 378

  Fly   381 CFLISSLLLWVCFLKSWKGDPGIIRPTREQRFKTIIELSERGGIGFEPASFCSGCLVRRPIRSKH 445
            .|:.|.:.....|.|:|..|||..:.:.|::...||.|:|.|.:.|.  :||:.||:|:|:||.|
Human   379 SFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFR--TFCTSCLIRKPLRSLH 441

  Fly   446 CSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYVNQCNVRF--DDF 508
            |.||:.||||:|.||.|.|.|||..||.|::.||:.|.::|.|::||...|..:.|...|  |..
Human   442 CHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSFIYLSSHCATTFKEDGL 506

  Fly   509 LGAMRAIGNCDAWVGWVMGNALLHMSWVILLTICQTYQVICLGMTTNERMNRGRYRHFQAKGGH- 572
            ...:..|..|..||.:::..|..|.||...|.:.|.:|:..||:|::||::      .|.:..|
Human   507 WTYLNQIVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAFLGLTSHERIS------LQKQSKHM 565

  Fly   573 --------SPFTRGPIQNLVDFLECSCFGLVQPKRVDWMNYY 606
                    :|:..|.:|||.||.:|.|||||:|..|||.:.|
Human   566 KQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCVVDWTSQY 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125	67/112 (60%)
		Ank_2	52..142	CDD:289560	56/89 (63%)
		ANK repeat	77..108	CDD:293786	18/30 (60%)
		ANK repeat	110..142	CDD:293786	20/31 (65%)
		ANK	114..233	CDD:238125	55/118 (47%)
		Ank_2	116..209	CDD:289560	41/92 (45%)
		ANK repeat	144..175	CDD:293786	13/30 (43%)
		ANK repeat	177..209	CDD:293786	10/31 (32%)
		Ank_5	198..251	CDD:290568	23/52 (44%)
		ANK repeat	212..244	CDD:293786	15/31 (48%)
		zf-DHHC	426..559	CDD:279823	55/134 (41%)
ZDHHC13	NP_061901.2	ANK 1. /evidence=ECO:0000250\|UniProtKB:Q8IUH5	43..78		20/34 (59%)
		ANK	79..192	CDD:238125	61/112 (54%)
		ANK repeat	81..112	CDD:293786	18/30 (60%)
		ANK 2. /evidence=ECO:0000255	81..110		17/28 (61%)
		ANK repeat	114..146	CDD:293786	20/31 (65%)
		ANK 3. /evidence=ECO:0000255	115..144		20/28 (71%)
		ANKYR	<145..271	CDD:223738	49/131 (37%)
		ANK repeat	148..179	CDD:293786	13/30 (43%)
		ANK 4. /evidence=ECO:0000255	148..177		13/28 (46%)
		ANK repeat	181..247	CDD:293786	27/66 (41%)
		ANK 5. /evidence=ECO:0000255	181..211		10/29 (34%)
		ANK 6. /evidence=ECO:0000255	216..245		14/29 (48%)
		ANK 7. /evidence=ECO:0000255	249..277		9/43 (21%)
		zf-DHHC	423..559	CDD:307600	55/143 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152210
Domainoid	1	1.000	46	1.000	Domainoid score	I12137
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	573	1.000	Inparanoid score	I1048
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54696
OrthoDB	1	1.010	-	-		D213306at33208
OrthoFinder	1	1.000	-	-		FOG0001761
OrthoInspector	1	1.000	-	-		otm40352
orthoMCL	1	0.900	-	-		OOG6_101007
Panther	1	1.100	-	-	O	PTHR24161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770