DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and zdhhc2

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_021336686.1	Gene:	zdhhc2 / 541365	ZFINID:	ZDB-GENE-050320-58	Length:	374	Species:	Danio rerio

Alignment Length:	297	Identity:	69/297 - (23%)
Similarity:	113/297 - (38%)	Gaps:	76/297 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 GKALFD-EHLMALLPLSVYLATKAWFYVTWL--MYIDDAVSFTATVCFLISSLLLWVCFLKS-WK 398
            |...|| ..::..:|:.......||.|..::  :.|:...:......:|:...||::.|:.| |:
Zfish     5 GSRSFDCWRVLYWIPVLFISLIVAWSYYAYVVQLCIETIENMGEKTVYLLIYHLLFLMFVWSYWQ 69

  Fly   399 ---GDPGIIRPTREQRF----KTIIELSER-----------------------GGIGFEPASFCS 433
               ..|  :.|.:|...    |.::|..:|                       |.|     .:|.
Zfish    70 TIYSKP--MNPLKEFHLSHVDKELLEREDRRESQQEILRRIAKDLPIYTRTMSGAI-----RYCD 127

  Fly   434 GCLVRRPIRSKHCSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYV 498
            .||:.:|.|..|||.||.|:.:.|||||||.||:|..|:.:||.||...|:.|.::.....:|::
Zfish   128 RCLLLKPDRCHHCSACDMCILKMDHHCPWVNNCVGFANYKFFMLFLAYSLLYCLFVTATDMQYFI 192

  Fly   499 NQCNV------RFDDFLGAMRAIGNCDAWVGWVMGNALLHMSWVILLTICQTYQV---------- 547
            ....|      |...:|.            |.....|..|:  :.|.....|:.|
Zfish   193 QFWTVDGKTHDRLIQYLN------------GLPDTQAKFHI--MFLFFAASTFSVSLAFLFAYHC 243

  Fly   548 --ICLGMTTNERMNRGRYRHFQAKGGHSPFTRGPIQN 582
              :|...:|.|......::|...|.|   |:.|..:|
Zfish   244 WLVCKNRSTLEAFRAPAFQHGTDKNG---FSLGAYKN 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	41/150 (27%)
zdhhc2	XP_021336686.1	zf-DHHC	11..305	CDD:327686	66/291 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810